AC T01795
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ID T01795
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DT 06.05.1996 (created); ewi.
DT 30.05.2016 (updated); nes.
CO Copyright (C), QIAGEN.
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FA AhR
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SY Ah receptor; AhR; aryl hydrocarbon receptor.
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OS human, Homo sapiens
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; primates
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GE G004685 AHR; HGNC: AhR.
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CL C0010; bHLH; 1.2.5.1.1.
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SF heterodimerization with Arnt required for DNA-binding [3] [2];
SF interaction with hsp90 [1];
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EX adrenal gland (right and left),,,adult; detectable; RT-PCR; total RNA; [13].
EX brain,,,adult; low; Northern blot; RNA (undefined); [5].
EX heart,,,adult; medium; Northern blot; RNA (undefined); [5].
EX kidney (right and left),,,adult; low; Northern blot; RNA (undefined); [5].
EX liver,,,adult; detectable; RT-PCR; total RNA; [13].
EX liver,,,adult; medium; Northern blot; RNA (undefined); [5].
EX lung (right and left),,,adult; high; Northern blot; RNA (undefined); [5].
EX muscles,,,adult; low; Northern blot; RNA (undefined); [5].
EX ovary (right and left),,,adult; detectable; RT-PCR; total RNA; [13].
EX pancreas,,,adult; medium; Northern blot; RNA (undefined); [5].
EX placenta,,,adult; very high; Northern blot; RNA (undefined); [5].
EX testis (right and left),,,adult; detectable; RT-PCR; total RNA; [13].
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FF binds to xenobiotic response element;
FF dioxin-induced DNA binding and gene induction by AhR is down-regulated by cobalt ions (or hypoxia) through activation of HIF-1alpha competing for the dimerization partner Arnt [7] [8];
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IN T01346 arnt-isoform1; human, Homo sapiens.
IN T01797 arnt; mouse, Mus musculus.
IN T02720 BMAL1; human, Homo sapiens.
IN T05451 BRG1; human, Homo sapiens.
IN T00149 COUP-TF1; human, Homo sapiens.
IN T00261 ER-alpha; human, Homo sapiens.
IN T02765 ERR1; human, Homo sapiens.
IN T00992 Hsp90; human, Homo sapiens.
IN T21984 p300; human, Homo sapiens.
IN T00722 pRb; human, Homo sapiens.
IN T00594 RelA-p65-isoform1; human, Homo sapiens.
IN T00754 Sp1; rat, Rattus norvegicus.
IN T04632 SRC-1; human, Homo sapiens.
IN T04638 SRC3; mouse, Mus musculus.
IN T02482 TIF2; mouse, Mus musculus.
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MX M00235 V$AHRARNT_01.
MX M00237 V$AHRARNT_02.
MX M00976 V$AHRHIF_Q6.
MX M00139 V$AHR_01.
MX M00778 V$AHR_Q5.
MX M01855 V$AHR_Q6.
MX M07347 V$AHR_Q6_01.
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BS R02117.
BS R02720.
BS R12152.
BS R12194.
BS R39628.
BS R37174.
BS R37175.
BS R37176.
BS R31421.
BS R64885.
BS R57285.
BS R33930.
BS R62634.
BS R62635.
BS R13159.
BS R13160.
BS R13161.
BS R13162.
BS R13163.
BS R39629.
BS R62633.
BS R29931.
BS R59581.
BS R59583.
BS R41678.
BS R62746.
BS R13296.
BS R60494.
BS R57895.
BS R73018.
BS R73027.
BS R73028.
BS R33929.
BS R66417.
BS R60675.
BS R13274.
BS R29597.
BS R34085.
BS R34130.
BS R34131.
BS R13226.
BS R13227.
BS R13228.
BS R02651.
BS R24735.
BS R34038.
BS R00270.
BS R30403.
BS R29363.
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DR TRANSPATH: MO000025932.
DR UniProtKB: P35869;
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RN [1]; RE0001108.
RX PUBMED: 2843537.
RA Perdew G. H.
RT Association of the Ah receptor with the 90-kDa heat shock protein
RL J. Biol. Chem. 263:13802-13806 (1988).
RN [2]; RE0002644.
RX PUBMED: 1852076.
RA Hoffman E. C., Reyes H., Chu F.-F., Sander F., Conley H., Brooks B. A., Hankinson O.
RT Cloning of a factor required for activity of the Ah (dioxin) receptor
RL Science 252:954-958 (1991).
RN [3]; RE0004045.
RX PUBMED: 1317062.
RA Reyes H., Reisz-Porszasz S., Hankinson O.
RT Identification of the Ah receptor nuclear translocator protein (Arnt) as a component of the DNA binding form of the Ah receptor
RL Science 256:1193-1195 (1992).
RN [4]; RE0004046.
RX PUBMED: 8393992.
RA Itoh S., Kamataki T.
RT Human Ah receptor cDNA: analysis for highly conserved sequences
RL Nucleic Acids Res. 21:3578-3578 (1993).
RN [5]; RE0004047.
RX PUBMED: 8246913.
RA Dolwick K. M., Schmidt J. V., Carver L. A., Swanson H. I., Bradfield C. A.
RT Cloning and expression of a human Ah receptor cDNA
RL Mol. Pharmacol. 44:911-917 (1993).
RN [6]; RE0004049.
RX PUBMED: 8163517.
RA de Morais S. M. F., Giannone J. V., Okey A. B.
RT Photoaffinity labeling of Ah receptor with 3-[3H]methylcolanthrene and formation of a 165-kDa complex between the ligand-binding subunit and a novel cytosolic protein
RL J. Biol. Chem. 269:12129-12136 (1994).
RN [7]; RE0013068.
RX PUBMED: 8816435.
RA Gradin K., Guire J., Wenger R. H., Kvietikova I., Whitelaw M. L., Toftgard R., Tora L., Gassmann M., Poellinger L.
RT Functional interference between hypoxia and dioxin signal transduction pathways: competition for recruitment of the Arnt transcription factor
RL Mol. Cell. Biol. 16:5221-5231 (1996).
RN [8]; RE0022396.
RX PUBMED: 10207038.
RA Chan W. K., Yao G., Gu Y. Z., Bradfield C. A.
RT Cross-talk between the aryl hydrocarbon receptor and hypoxia inducible factor signaling pathways. Demonstration of competition and compensation.
RL J. Biol. Chem. 274:12115-12123 (1999).
RN [9]; RE0022462.
RX PUBMED: 12409613.
RA Song J., Clagett-Dame M., Peterson R. E., Hahn M. E., Westler W. M., Sicinski R. R., DeLuca H. F.
RT A ligand for the aryl hydrocarbon receptor isolated from lung.
RL Proc. Natl. Acad. Sci. USA 99:14694-14699 (2002).
RN [10]; RE0022504.
RX PUBMED: 10731723.
RA Ikuta T., Tachibana T., Watanabe J., Yoshida M., Yoneda Y., Kawajiri K.
RT Nucleocytoplasmic shuttling of the aryl hydrocarbon receptor.
RL J. Biochem. 127:503-509 (2000).
RN [11]; RE0047822.
RX PUBMED: 10903152.
RA Hulkko S. M., Wakui H., Zilliacus J.
RT The pro-apoptotic protein death-associated protein 3 (DAP3) interacts with the glucocorticoid receptor and affects the receptor function.
RL Biochem. J. 349:885-893 (2000).
RN [12]; RE0066126.
RX PUBMED: 20053997.
RA Kalthoff S., Ehmer U., Freiberg N., Manns M. P., Strassburg C. P.
RT Interaction between oxidative stress sensor Nrf2 and xenobiotic-activated aryl hydrocarbon receptor in the regulation of the human phase II detoxifying UDP-glucuronosyltransferase 1A10.
RL J. Biol. Chem. 285:5993-6002 (2010).
RN [13]; RE0022306.
RX PUBMED: 11595506.
RA Sugawara T., Nomura E., Sakuragi N., Fujimoto S.
RT The effect of the arylhydrocarbon receptor on the human steroidogenic acute regulatory gene promoter activity.
RL J. Steroid Biochem. Mol. Biol. 78:253-260 (2001).
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