AC T00754
XX
ID T00754
XX
DT 15.10.1992 (created); ewi.
DT 09.02.2016 (updated); nes.
CO Copyright (C), QIAGEN.
XX
FA Sp1
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SY Sp1; Stimulating Protein 1.
XX
OS rat, Rattus norvegicus
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae
XX
GE G009203 Sp1.
XX
CL C0001; CH; 2.3.1.1.1.
XX
CP ubiquitous [11]; IGF-1 treated PC-12 cells [15].
XX
FF phosphorylation of Sp1 upon exposure to FGF-2 switches Sp1 from an activator to a repressor of PDGFRalpha transcription [16];
FF activator, most abundant expression in thymus and spleen [11];
FF treatment with oxidizing agent strongly decreases binding efficiency [12];
FF involved in mediating ethanol-induced stress [14];
XX
IN T01795 AhR; human, Homo sapiens.
IN T01346 arnt-isoform1; human, Homo sapiens.
IN T00205 E2; BPV-1, bovine papilloma virus type 1.
IN T14002 GKLF; mouse, Mus musculus.
IN T15112 GKLF; rat, Rattus norvegicus.
IN T04434 LXR-alpha; rat, Rattus norvegicus.
IN T00088 NF-YA; rat, Rattus norvegicus.
IN T09945 p300; rat, Rattus norvegicus.
IN T05329 PPARgamma; rat, Rattus norvegicus.
IN T10028 SREBP-1c; rat, Rattus norvegicus.
IN T06605 STAT3; rat, Rattus norvegicus.
XX
MX M00008 V$SP1_01.
MX M01303 V$SP1_02.
MX M00933 V$SP1_Q2_01.
MX M07395 V$SP1_Q2_02.
MX M00932 V$SP1_Q4_01.
MX M00196 V$SP1_Q6.
MX M00931 V$SP1_Q6_01.
XX
BS R04684.
BS R18719.
BS R21085.
BS R21007.
BS R21682.
BS R32523.
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BS R40068.
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BS R57966.
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BS R26774.
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BS R11589.
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BS R56293.
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BS R24290.
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BS R01023.
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BS R14957.
BS R16545.
BS R57621.
BS R21091.
BS R21172.
BS R03612.
BS R03613.
BS R03614.
BS R04743.
BS R19587.
BS R63062.
BS R17179.
BS R20997.
BS R21004.
BS R38278.
BS R38283.
BS R38284.
BS R26735.
BS R26736.
BS R26738.
BS R26740.
BS R32650.
BS R39046.
BS R39047.
BS R64925.
BS R21328.
BS R21330.
BS R35997.
BS R03317.
BS R33611.
BS R33612.
BS R33615.
BS R61624.
BS R61625.
BS R67487.
BS R67488.
BS R34080.
BS R34082.
BS R21846.
BS R21314.
BS R21315.
BS R21356.
BS R56478.
BS R24639.
BS R24640.
BS R24641.
BS R22618.
BS R08166.
BS R27802.
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BS R27804.
BS R39743.
BS R39746.
BS R32675.
BS R31851.
BS R37961.
BS R60969.
BS R61873.
BS R28991.
BS R30663.
BS R21554.
BS R61446.
BS R32600.
BS R40454.
BS R24167.
BS R24168.
BS R24169.
BS R24170.
BS R24171.
BS R55954.
BS R05012.
BS R05013.
BS R01484.
BS R27534.
BS R71741.
BS R71755.
BS R71756.
BS R39698.
BS R39699.
BS R39701.
BS R39702.
BS R39703.
BS R24938.
BS R24945.
BS R39369.
BS R60777.
BS R33828.
BS R60250.
BS R41664.
BS R02245.
BS R31954.
BS R01381.
BS R39416.
XX
DR TRANSPATH: MO000012882.
DR TRANSCOMPEL: C00274.
DR TRANSCOMPEL: C00359.
DR TRANSCOMPEL: C00441.
DR TRANSCOMPEL: C00442.
DR TRANSCOMPEL: C00529.
DR UniProtKB: Q01714;
XX
RN [1]; RE0000182.
RX PUBMED: 2170018.
RA Jackson S. P., MacDonald J. J., Lees-Miller S., Tjian R.
RT GC box binding induces phosphorylation by a DNA-dependent protein kinase
RL Cell 63:155-165 (1990).
RN [2]; RE0000692.
RX PUBMED: 2163346.
RA Saffer J. D., Jackson S. P., Thurston S. J.
RT SV40 stimulates expression of the trans-acting factor Sp1 at the mRNA level
RL Genes Dev. 4:659-666 (1990).
RN [3]; RE0000693.
RX PUBMED: 1851121.
RA Su W., Jackson S., Tjian R., Echols H.
RT DNA looping between site for transcriptional activation: self-association of DNA-bound Sp1
RL Genes Dev. 5:820-826 (1991).
RN [4]; RE0000840.
RX PUBMED: 2463987.
RA Choy H. A., McLaughlin M., Feigelson P.
RT Nuclear Factors from Expressing Tissues Interact in Vitro with with a Rat alpha-2u Globulin Gene Intron
RL J. Biol. Chem. 264:1754-1759 (1989).
RN [5]; RE0001024.
RX PUBMED: 2026618.
RA Takiguchi M., Mori M.
RT In vitro analysis of the rat liver-type arginase promoter
RL J. Biol. Chem. 266:9186-9193 (1991).
RN [6]; RE0001246.
RX PUBMED: 3043186.
RA Morgan J. G., Courtois G., Fourel G., Chodosh L. A., Campbell L., Evans E., Crabtree G. R.
RT Sp1, a CAAT-Binding Factor, and the Adenovirus Major Late Promoter Transcription Factor Interact with Functional Regions of the Gamma-Fibrinogen Promoter
RL Mol. Cell. Biol. 8:2628-2637 (1988).
RN [7]; RE0001271.
RX PUBMED: 2181288.
RA Lemaigre F. P., Lafontaine D. A., Courtois S. J., Durviaux S. M., Rousseau G. G.
RT Sp1 can displace GHF-1 from its distal binding site and stimulate transcription from the growth hormone gene promoter
RL Mol. Cell. Biol. 10:1811-1814 (1990).
RN [8]; RE0001375.
RX PUBMED: 2677669.
RA Schmidt M. C., Zhou Q., Berk A. J.
RT Sp1 Activates Transcription without Enhancing DNA-Binding Activity of the TATA Box Factor
RL Mol. Cell. Biol. 9:3299-3307 (1989).
RN [9]; RE0001495.
RX PUBMED: 2005904.
RA Saffer J. D., Jackson S. P., Annarella M. B.
RT Developmental expression of Sp1 in the mouse
RL Mol. Cell. Biol. 11:2189-2199 (1991).
RN [10]; RE0002079.
RX PUBMED: 1976240.
RA Schaufele F., West B. L., Reudelhuber T.
RT Somatotroph- and lactotroph-specific interactions with the homeobox protein binding sites in the rat growth hormone gene promoter
RL Nucleic Acids Res. 18:5235-5244 (1990).
RN [11]; RE0005868.
RX PUBMED: 1356762.
RA Imataka H., Sogawa K., Yasumoto K.-i., Kikuchi Y., Sasano K., Kobayashi A., Hayami M., Fujii-Kuriyama Y.
RT Two regulatory proteins that bind to the basic transcription element (BTE), a GC box sequence in the promoter region of the rat P-4501A1 gene
RL EMBO J. 11:3663-3671 (1992).
RN [12]; RE0006718.
RX PUBMED: 7925470.
RA Ammendola R., Mesuraca M., Russo T., Cimino F.
RT The DNA-binding efficiency of Sp1 is affected by redox changes
RL Eur. J. Biochem. 225:483-489 (1994).
RN [13]; RE0016556.
RX PUBMED: 2123467.
RA Sartorelli V., Webster K. A., Kedes L.
RT Muscle-specific expression of the cardiac alpha-actin gene requires MyoD, CArG-box binding factor, and Sp1.
RL Genes Dev. 4:1811-1822 (1990).
RN [14]; RE0017075.
RX PUBMED: 10604945.
RA Wilke N., Sganga M. W., Gayer G. G., Hsieh K. P., Miles M. F.
RT Characterization of promoter elements mediating ethanol regulation of hsc70 gene transcription
RL J. Pharmacol. Exp. Ther. 292:173-180 (2000).
RN [15]; RE0025856.
RX PUBMED: 14592960.
RA Wang G., Leiter A. B., Englander E. W., Greeley G. H. Jr.
RT Insulin-like growth factor I increases rat peptide YY promoter activity through Sp1 binding sites.
RL Endocrinology 145:659-66 (2004).
RN [16]; RE0032906.
RX PUBMED: 14593115.
RA Bonello M. R., Khachigian L. M.
RT Fibroblast growth factor-2 represses platelet-derived growth factor receptor-alpha (PDGFR-alpha) transcription via ERK1/2-dependent Sp1 phosphorylation and an atypical cis-acting element in the proximal PDGFR-alpha promoter.
RL J. Biol. Chem. 279:2377-82 (2004).
RN [17]; RE0052791.
RX PUBMED: 17449871.
RA Deng X., Yellaturu C., Cagen L., Wilcox H. G., Park E. A., Raghow R., Elam M. B.
RT Expression of the rat sterol regulatory element-binding protein-1c gene in response to insulin is mediated by increased transactivating capacity of specificity protein 1 (Sp1).
RL J. Biol. Chem. 282:17517-17529 (2007).
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