AC T04434
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ID T04434
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DT 18.04.2001 (created); mas.
DT 23.01.2014 (updated); yre.
CO Copyright (C), QIAGEN.
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FA LXR-alpha
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SY liver X receptor alpha; LXR; LXR A; LXR-A; NR1H3; nuclear orphan receptor LXR-alpha; oxysterol receptor LXR-alpha; oxysterol receptor LXRalpha; RLD1.
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OS rat, Rattus norvegicus
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae
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GE G002452 Nr1h3.
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CL C0002; CC (rec); 2.1.2.7.1.
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SF P-Box (contributes in general to DNA-binding specificity) in DNA-binding domain is conserved [2];
SF probably weak binding to retinoic-acid response element beta (RARE-beta);
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CP (adult:) strong in spleen [1] [2], pituitary gland, fat tissue, lung [2] and in metabolic organs such as liver, kidney, intestine [1]; weak in prostate, skin [2] and probably in adrenals [1], stomach [2]; unclear wether low levels in testis are present [2] or not [1] [1] [2].
CN eye [2], heart, brain [1] [2] and brain components such as cerebellum, cerebrum, midbrain, brainstem, olfactory bulb [2]; [1] [2].
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FF as heterodimer with rat RXRalpha T04383 transcriptional activation of reporter genes linked to artificial DR-4 like repeat R09934 [2];
FF mRNA is indirectly induced by insulin, therefore is an important mediator of insulin effects in liver [3];
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IN T04383 RXR-alpha; rat, Rattus norvegicus.
IN T00754 Sp1; rat, Rattus norvegicus.
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MX M00965 V$DR4_Q2.
MX M00647 V$LXR_Q3.
MX M03795 V$LXR_Q6.
MX M07280 V$NR1NR2_Q3.
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BS R09968.
BS R24184.
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DR TRANSPATH: MO000028287.
DR UniProtKB: Q62685;
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RN [1]; RE0010391.
RX PUBMED: 7744246.
RA Willy P. J., Umesono K., Ong E. S., Evans R. M., Heyman R. A., Mangelsdorf D. J.
RT LXR, a nuclear receptor that defines a distinct retinoid response pathway
RL Genes Dev. 9:1033-1045 (1995).
RN [2]; RE0016052.
RX PUBMED: 7935418.
RA Apfel R., Benbrook D., Lernhardt E., Ortiz M. A., Salbert G., Pfahl M.
RT A novel orphan receptor specific for a subset of thyroid hormone-responsive elements and its interaction with the retinoid/thyroid hormone receptor subfamily
RL Mol. Cell. Biol. 14:7025-7035 (1994).
RN [3]; RE0023594.
RX PUBMED: 11781314.
RA Tobin K. A., Ulven S. M., Schuster G. U., Steineger H. H., Andresen S. M., Gustafsson J. A., Nebb H. I.
RT Liver X receptors as insulin-mediating factors in fatty acid and cholesterol biosynthesis.
RL J. Biol. Chem. 277:10691-10697 (2002).
RN [4]; RE0052791.
RX PUBMED: 17449871.
RA Deng X., Yellaturu C., Cagen L., Wilcox H. G., Park E. A., Raghow R., Elam M. B.
RT Expression of the rat sterol regulatory element-binding protein-1c gene in response to insulin is mediated by increased transactivating capacity of specificity protein 1 (Sp1).
RL J. Biol. Chem. 282:17517-17529 (2007).
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