AC T04383
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ID T04383
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DT 21.03.2001 (created); vma.
DT 11.04.2014 (updated); vad.
CO Copyright (C), QIAGEN.
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FA RXR-alpha
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SY NR2B1; retinoid X receptor alpha.
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OS rat, Rattus norvegicus
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae
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GE G008908 Rxra.
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CL C0002; CC (rec); 2.1.3.1.1.
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SF forms homodimers and heterodimers with a number of different nuclear receptors: RAR-alpha, -beta, -gamma, TR-alpha, ARP-1, PPAR-alpha, VDR, CAR, LXR, FXR, FXRbeta;
SF for heterodimers, see ;
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CP (adult:) high levels in liver, kidney, lung, muscle, spleen [1]; low levels in adrenal, brain, heart, intestine, testis [1] [1].
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FF natural agonist ligand: 9-cis-Retinoic Acid;
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IN T05312 CAR; rat, Rattus norvegicus.
IN T04434 LXR-alpha; rat, Rattus norvegicus.
IN T04451 LXR-beta; rat, Rattus norvegicus.
IN T05962 NCOR1; rat, Rattus norvegicus.
IN T10152 NR1B2; rat, Rattus norvegicus.
IN T00991 PPARalpha; rat, Rattus norvegicus.
IN T04646 TIF2; rat, Rattus norvegicus.
IN T00885 VDR; human, Homo sapiens.
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MX M00966 V$DR3_Q4.
MX M00965 V$DR4_Q2.
MX M07280 V$NR1NR2_Q3.
MX M00518 V$PPARA_02.
MX M00963 V$T3R_Q6.
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BS R27381.
BS R20525.
BS R20531.
BS R58685.
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DR TRANSPATH: MO000028238.
DR UniProtKB: Q05343;
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RN [1]; RE0000789.
RX PUBMED: 1312497.
RA Mangelsdorf D. J., Borgmeyer U., Heyman R. A., Zhou J. Y., Ong E. S., Oro A. E., Kakizuka A., Evans R. M.
RT Characterization of three RXR genes that mediate the action of 9-cis retinoic acid
RL Genes Dev. 6:329-344 (1992).
RN [2]; RE0047740.
RX PUBMED: 15234273.
RA Wang L., Tankersley L. R., Tang M., Potter J. J., Mezey E.
RT Regulation of alpha 2(I) collagen expression in stellate cells by retinoic acid and retinoid X receptors through interactions with their cofactors.
RL Arch. Biochem. Biophys. 428:92-98 (2004).
RN [3]; RE0051730.
RX PUBMED: 17368182.
RA Arriagada G., Paredes R., Olate J., van Wijnen A., Lian J. B., Stein G. S., Stein J. L., Onate S., Montecino M.
RT Phosphorylation at serine 208 of the 1alpha,25-dihydroxy Vitamin D3 receptor modulates the interaction with transcriptional coactivators.
RL J. Steroid Biochem. Mol. Biol. 103:425-429 (2007).
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