TRANSFAC FACTOR TABLE, Release 2017.2 - public - 2017-06-30, (C) QIAGEN

AC T04451 XX ID T04451 XX DT 26.04.2001 (created); mas. DT 23.01.2014 (updated); yre. CO Copyright (C), QIAGEN. XX FA LXR-beta XX SY LXR B; LXR-B; LXRB; NER; NR1H2; nuclear orphan receptor LXR-beta; orphan nuclear receptor OR-1; oxysterol receptor LXR-beta; ubiquitously expressed nuclear receptor; UR. XX OS rat, Rattus norvegicus OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae XX GE G002741 Nr1h2. XX CL C0002; CC (rec); XX SF conflict in protein sequence between EMBL entries #U14533 (443 aa) and #U20389 (446 aa): insertion of 3 aa at pos. 53 and substitution at pos. 33 (G versus V); SF subcellular location predominantly nuclear [3]; SF long N-terminal domain (77aa) domain mainly consisting of PEST sequence, which is apparently characteristic for proteins with short half-lives [2]; SF ligand-binding domain (LBD) not highly homologous to other members of the nuclear receptor family [3]; SF contains a 5 aa P-Box which is supposed to be responsible for hormone response element (HRE) half-site recognition in other nuclear receptors [2] [1] [3]; SF a heptad-repeat leucin zipper structure in the C-terminal ligand binding domain is suspected to be important for heterodimerization [3]; SF heterodimerization with RXR-alpha T04383 even in the absence of DNA and formation of a complex with transactivation capability [2]; SF forms homodimers (which bind to R09956 but with poor transcriptional transactivation activity) [3]; XX CP ubiquitous expression in fetal and adult tissues [2] [3]; (fetal:) (in situ) high levels in thymus, brown fat tissue, spleen gastrointestinal tract, salivary gland, thyroid gland, pituitary gland, retina and moderate levels in liver lung heart, skin [2]; (adult:) high levels in liver, ovary, heart, testis, vagina, uterus, kidney, adrenal, spleen [3] and brain (cerebellum and hippocampus [2]) and in situ in lymph node and prostate [2] [2] [3]. XX FF enhances transcriptional transactivation activity of RXR-alpha T04383 most likely by forming heterodimers: this increase is higher upon exposure to natural ligand (9-cis retinoid acid) but occurs even in its absence [2]; FF evidence for modulation of gene activation in retinoic acid and thyroid hormone signaling pathways in an inhibitory manner: presence of factor apparently decreases transcriptional transactivation activity of heterodimer RXR-alpha/RAR-alpha1 and homodimer of RXR-alpha T01345 at binding site R09956 [3]; XX IN T04451 LXR-beta; rat, Rattus norvegicus. IN T01345 RXR-alpha; human, Homo sapiens. IN T04383 RXR-alpha; rat, Rattus norvegicus. IN T00851 T3R-beta1; human, Homo sapiens. XX MX M00965 V$DR4_Q2. MX M00647 V$LXR_Q3. MX M03795 V$LXR_Q6. MX M07280 V$NR1NR2_Q3. XX DR TRANSPATH: MO000028301. DR UniProtKB: Q62755; XX RN [1]; RE0001904. RX PUBMED: 2922054. RA Mader S., Kumar V., de Verneuil H., Chambon P. RT Three amino acids of the oestrogen receptor are essential to its ability to distinguish an oestrogen from a glucocorticoid-responsive element RL Nature 338:271-275 (1989). RN [2]; RE0010769. RX PUBMED: 7892230. RA Teboul M., Enmark E., Li Q., Wikstrom A. C., Pelto-Huikko M., Gustafsson J.-A. RT OR-1, a member of the nuclear receptor superfamily that interacts with the 9-cis-retinoic acid receptor RL Proc. Natl. Acad. Sci. USA 92:2096-2100 (1995). RN [3]; RE0016034. RX PUBMED: 7971966. RA Song C., Kokontis J. M., Hiipakka R. A., Liao S. RT Ubiquitous receptor: a receptor that modulates gene activation by retinoic acid and thyroid hormone receptors RL Proc. Natl. Acad. Sci. USA 91:10809-10813 (1994). XX //