AC T06605
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ID T06605
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DT 24.05.2005 (created); oke.
DT 25.02.2015 (updated); hna.
CO Copyright (C), QIAGEN.
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FA STAT3
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SY signal transducer and activator of transcription 3; STAT3.
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OS rat, Rattus norvegicus
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae
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GE G014152 Stat3.
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CL C0039; STAT; 6.2.1.0.3.
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IN T00333 GR; rat, Rattus norvegicus.
IN T09945 p300; rat, Rattus norvegicus.
IN T00754 Sp1; rat, Rattus norvegicus.
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MX M00225 V$STAT3_01.
MX M00497 V$STAT3_02.
MX M01595 V$STAT3_03.
MX M07065 V$STAT3_Q4.
MX M00223 V$STAT_01.
MX M00777 V$STAT_Q6.
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BS R12445.
BS R20996.
BS R29962.
BS R34181.
BS R33819.
BS R17089.
BS R04252.
BS R14446.
BS R14447.
BS R29939.
BS R35693.
BS R30086.
BS R66447.
BS R64919.
BS R29855.
BS R29445.
BS R26438.
BS R35690.
BS R35691.
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DR TRANSPATH: MO000013124.
DR TRANSCOMPEL: C00305.
DR UniProtKB: P52631; P52631.
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RN [1]; RE0003511.
RX PUBMED: 8272872.
RA Luetticken C., Wegenka U.M., Yuan J., Buschmann J., Schindler C., Ziemiecki A., Harpur A. G., Wilks A. F., Yasukawa K., Taga T., Kishimoto T., Barbieri G., Pellegrini S., Sendtner M., Heinrich P. C., Horn F.
RT Association of transcription factor APRF and protein kinase Jak1 with the interleukin-6 transducer gp130
RL Science 263:89-92 (1994).
RN [2]; RE0016910.
RX PUBMED: 8530402.
RA Ripperger J. A., Fritz S., Richter K., Hocke G. M., Lottspeich F., Fey G. H.
RT Transcription factors Stat3 and Stat5b are present in rat liver nuclei late in an acute phase response and bind interleukin-6 response elements.
RL J. Biol. Chem. 270:29998-30006 (1995).
RN [3]; RE0028947.
RX PUBMED: 9351438.
RA Kodama H., Fukuda K., Pan J., Makino S., Baba A., Hori S., Ogawa S.
RT Leukemia inhibitory factor, a potent cardiac hypertrophic cytokine, activates the JAK/STAT pathway in rat cardiomyocytes.
RL Circ. Res. 81:656-63 (1997).
RN [4]; RE0032458.
RX PUBMED: 9545305.
RA Oh H., Fujio Y., Kunisada K., Hirota H., Matsui H., Kishimoto T., Yamauchi-Takihara K.
RT Activation of phosphatidylinositol 3-kinase through glycoprotein 130 induces protein kinase B and p70 S6 kinase phosphorylation in cardiac myocytes.
RL J. Biol. Chem. 273:9703-10 (1998).
RN [5]; RE0032983.
RX PUBMED: 12855672.
RA Nakaoka Y., Nishida K., Fujio Y., Izumi M., Terai K., Oshima Y., Sugiyama S., Matsuda S., Koyasu S., Yamauchi-Takihara K., Hirano T., Kawase I., Hirota H.
RT Activation of gp130 transduces hypertrophic signal through interaction of scaffolding/docking protein Gab1 with tyrosine phosphatase SHP2 in cardiomyocytes.
RL Circ. Res. 93:221-9 (2003).
RN [6]; RE0035922.
RX PUBMED: 10900165.
RA Kuwahara K., Saito Y., Kishimoto I., Miyamoto Y., Harada M., Ogawa E., Hamanaka I., Kajiyama N., Takahashi N., Izumi T., Kawakami R., Nakao K.
RT Cardiotrophin-1 phosphorylates akt and BAD, and prolongs cell survival via a PI3K-dependent pathway in cardiac myocytes.
RL J. Mol. Cell. Cardiol. 32:1385-1394 (2000).
RN [7]; RE0047403.
RX PUBMED: 15659653.
RA Hao A., Novotny-Diermayr V., Bian W., Lin B., Lim C. P., Jing N., Cao X.
RT The LIM/homeodomain protein Islet1 recruits Janus tyrosine kinases and signal transducer and activator of transcription 3 and stimulates their activities.
RL Mol. Biol. Cell 16:1569-1583 (2005).
RN [8]; RE0050250.
RX PUBMED: 16611639.
RA Ng Y. P., Cheung Z. H., Ip N. Y.
RT STAT3 as a downstream mediator of Trk signaling and functions.
RL J. Biol. Chem. 281:15636-15644 (2006).
RN [9]; RE0052344.
RX PUBMED: 9388192.
RA Zhang Z., Jones S., Hagood J. S., Fuentes N. L., Fuller G. M.
RT STAT3 acts as a co-activator of glucocorticoid receptor signaling.
RL J. Biol. Chem. 272:30607-30610 (1997).
RN [10]; RE0052636.
RX PUBMED: 18235084.
RA Xu Z. G., Yuan H., Lanting L., Li S. L., Wang M., Shanmugam N., Kato M., Adler S. G., Reddy M. A., Natarajan R.
RT Products of 12/15-lipoxygenase upregulate the angiotensin II receptor.
RL J. Am. Soc. Nephrol. 19:559-569 (2008).
RN [11]; RE0053892.
RX PUBMED: 16427075.
RA Izumi M., Masaki M., Hiramoto Y., Sugiyama S., Kuroda T., Terai K., Hori M., Kawase I., Hirota H.
RT Cross-talk between bone morphogenetic protein 2 and leukemia inhibitory factor through ERK 1/2 and Smad1 in protection against doxorubicin-induced injury of cardiomyocytes.
RL J. Mol. Cell. Cardiol. 40:224-233 (2006).
RN [12]; RE0053951.
RX PUBMED: 14511121.
RA Kaur N., Kim I. J., Higgins D., Halvorsen S. W.
RT Induction of an interferon-gamma Stat3 response in nerve cells by pre-treatment with gp130 cytokines.
RL J. Neurochem 87:437-447 (2003).
RN [13]; RE0054127.
RX PUBMED: 10858440.
RA Blanchard F., Duplomb L., Wang Y., Robledo O., Kinzie E., Pitard V., Godard A., Jacques Y., Baumann H.
RT Stimulation of leukemia inhibitory factor receptor degradation by extracellular signal-regulated kinase.
RL J. Biol. Chem. 275:28793-28801 (2000).
RN [14]; RE0063210.
RX PUBMED: 17855367.
RA Xu K., Kitchen C. M., Shu H. K., Murphy T. J.
RT Platelet-derived growth factor-induced stabilization of cyclooxygenase 2 mRNA in rat smooth muscle cells requires the c-Src family of protein-tyrosine kinases.
RL J. Biol. Chem. 282:32699-32709 (2007).
RN [15]; RE0064118.
RX PUBMED: 19336676.
RA Moore F., Colli M. L., Cnop M., Esteve M. I., Cardozo A. K., Cunha D. A., Bugliani M., Marchetti P., Eizirik D. L.
RT PTPN2, a candidate gene for type 1 diabetes, modulates interferon-gamma-induced pancreatic beta-cell apoptosis.
RL Diabetes 58:1283-1291 (2009).
RN [16]; RE0064812.
RX PUBMED: 15694390.
RA Jeon S. B., Ji K. A., You H. J., Kim J. H., Jou I., Joe E. H.
RT Nordihydroguaiaretic acid inhibits IFN-gamma-induced STAT tyrosine phosphorylation in rat brain astrocytes.
RL Biochem. Biophys. Res. Commun. 328:595-600 (2005).
RN [17]; RE0067378.
RX PUBMED: 10409724.
RA Kim H., Baumann H.
RT Dual signaling role of the protein tyrosine phosphatase SHP-2 in regulating expression of acute-phase plasma proteins by interleukin-6 cytokine receptors in hepatic cells.
RL Mol. Cell. Biol. 19:5326-5338 (1999).
RN [18]; RE0067469.
RX PUBMED: 18562323.
RA White U. A., Stewart W. C., Mynatt R. L., Stephens J. M.
RT Neuropoietin attenuates adipogenesis and induces insulin resistance in adipocytes.
RL J. Biol. Chem. 283:22505-22512 (2008).
RN [19]; RE0069055.
RX PUBMED: 12150983.
RA Sun Y., Marz P., Otten U., Ge J., Rose-John S.
RT The effect of gp130 stimulation on glutamate-induced excitotoxicity in primary hippocampal neurons.
RL Biochem. Biophys. Res. Commun. 295:532-539 (2002).
RN [20]; RE0069064.
RX PUBMED: 9875235.
RA Tone E., Kunisada K., Fujio Y., Matsui H., Negoro S., Oh H., Kishimoto T., Yamauchi-Takihara K.
RT Angiotensin II interferes with leukemia inhibitory factor-induced STAT3 activation in cardiac myocytes.
RL Biochem. Biophys. Res. Commun. 253:147-150 (1998).
RN [21]; RE0069194.
RX PUBMED: 21245987.
RA Gressner O. A., Peredniene I., Gressner A. M.
RT Connective tissue growth factor reacts as an IL-6/STAT3-regulated hepatic negative acute phase protein.
RL World J. Gastroenterol. 17:151-163 (2011).
RN [22]; RE0069330.
RX PUBMED: 15476586.
RA Chipoy C., Berreur M., Couillaud S., Pradal G., Vallette F., Colombeix C., Redini F., Heymann D., Blanchard F.
RT Downregulation of osteoblast markers and induction of the glial fibrillary acidic protein by oncostatin M in osteosarcoma cells require PKCdelta and STAT3.
RL J. Bone Miner. Res. 19:1850-1861 (2004).
RN [23]; RE0069470.
RX PUBMED: 18669911.
RA Bhattacharya S., Das A. V., Mallya K. B., Ahmad I.
RT Ciliary neurotrophic factor-mediated signaling regulates neuronal versus glial differentiation of retinal stem cells/progenitors by concentration-dependent recruitment of mitogen-activated protein kinase and Janus kinase-signal transducer and activator of transcription pathways in conjunction with Notch signaling.
RL Stem Cells 26:2611-2624 (2008).
RN [24]; RE0069498.
RX PUBMED: 18537819.
RA Zhang H., Feng W., Liao W., Ma X., Han Q., Zhang Y.
RT The gp130/STAT3 signaling pathway mediates beta-adrenergic receptor-induced atrial natriuretic factor expression in cardiomyocytes.
RL FEBS J. 275:3590-3597 (2008).
RN [25]; RE0070029.
RX PUBMED: 21325207.
RA Ahmad R., Rajabi H., Kosugi M., Joshi M. D., Alam M., Vasir B., Kawano T., Kharbanda S., Kufe D.
RT MUC1-C oncoprotein promotes STAT3 activation in an autoinductive regulatory loop.
RL Sci. Signal. 4:ra9 (2011).
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