AC T05329
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ID T05329
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DT 01.11.2002 (created); oke.
DT 09.09.2015 (updated); mka.
CO Copyright (C), QIAGEN.
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FA PPARgamma
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SY NR1C3; peroxisome proliferator-activated receptor gamma.
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OS rat, Rattus norvegicus
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae
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GE G004879 Pparg.
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CL C0002; CC (rec); 2.1.2.5.3.
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SF Two variants are known: PPARgamma1 T05330 and PPARgamma2 T05331 which probably result from differential splicing of PPARgamma mRNA [1];
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FF PPARgamma ligand rosiglitazone reduces the progression of pituitary GH-secreting tumors [2];
FF PPARgamma ligands increase apoptosis in GH3 [2];
FF PPARgamma ligands enhances the expression of TRAIL proteins [2];
FF PPARgamma ligands reduce the secretion of GH from GH3 cells [2];
FF PPARgamma ligands increase the number of cells in G1 phase and reduce the number of cells in S-phase in GH3 cells [2];
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IN T14002 GKLF; mouse, Mus musculus.
IN T15112 GKLF; rat, Rattus norvegicus.
IN T08930 RXR-alpha; rat, Rattus norvegicus.
IN T00754 Sp1; rat, Rattus norvegicus.
IN T04632 SRC-1; human, Homo sapiens.
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MX M00763 V$PPARDR1_Q2.
MX M00512 V$PPARG_01.
MX M00515 V$PPARG_02.
MX M00528 V$PPARG_03.
MX M01270 V$PPARG_Q6.
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BS R07669.
BS R39534.
BS R27359.
BS R27357.
BS R19238.
BS R61918.
BS R61920.
BS R61922.
BS R61923.
BS R61925.
BS R69660.
BS R69666.
BS R69667.
BS R69668.
BS R69669.
BS R69670.
BS R69671.
BS R64884.
BS R40738.
BS R65045.
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DR TRANSPATH: MO000033934.
DR EMBL: AF156665;
DR EMBL: AF156666;
DR UniProtKB: O88275;
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RN [1]; RE0018147.
RX PUBMED: 10438514.
RA Guardiola-Diaz H. M., Rehnmark S., Usuda N., Albrektsen T., Feltkamp D., Gustafsson J.-A., Alexson S. E. H.
RT Rat peroxisome proliferator-activated receptors and brown adipose tissue function during cold acclimatization.
RL J. Biol. Chem. 274:23368-23377 (1999).
RN [2]; RE0048626.
RX PUBMED: 15191358.
RA Bogazzi F., Ultimieri F., Raggi F., Russo D., Vanacore R., Guida C., Viacava P., Cecchetti D., Acerbi G., Brogioni S., Cosci C., Gasperi M., Bartalena L., Martino E.
RT PPARgamma inhibits GH synthesis and secretion and increases apoptosis of pituitary GH-secreting adenomas.
RL Eur. J. Endocrinol. 150:863-875 (2004).
RN [3]; RE0050430.
RX PUBMED: 16321982.
RA Tsukahara T., Tsukahara R., Yasuda S., Makarova N., Valentine W. J., Allison P., Yuan H., Baker D. L., Li Z., Bittman R., Parrill A., Tigyi G.
RT Different residues mediate recognition of 1-O-oleyllysophosphatidic acid and rosiglitazone in the ligand binding domain of peroxisome proliferator-activated receptor gamma.
RL J. Biol. Chem. 281:3398-3407 (2006).
RN [4]; RE0050623.
RX PUBMED: 9626662.
RA Treuter E., Albrektsen T., Johansson L., Leers J., Gustafsson J. A.
RT A regulatory role for RIP140 in nuclear receptor activation.
RL Mol. Endocrinol. 12:864-881 (1998).
RN [5]; RE0065202.
RX PUBMED: 16388013.
RA Banerjee J., Komar C. M.
RT Effects of luteinizing hormone on peroxisome proliferator-activated receptor gamma in the rat ovary before and after the gonadotropin surge.
RL Reproduction 131:93-101 (2006).
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