AC T00205
XX
ID T00205
XX
DT 15.10.1992 (created); ewi.
DT 07.07.2005 (updated); mkl.
CO Copyright (C), QIAGEN.
XX
FA E2
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SY E2.
XX
OS BPV-1, bovine papilloma virus type 1
OC viridae; ds-DNA nonenveloped viruses; papovaviridae; papillomavirus
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SF high molecular weight (> 85 kDa) after crosslinking;
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FF activator, cooperativity between two E2 sites;
FF complexes replication-stimulating viral E1, synergistic transcriptional activation with Sp1;
FF competitively displaces Sp1 from the adjacent binding site and does not bind cooperatively to the two target sites in HPV-16 promoter [10];
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IN T00203 E1; BPV-1, bovine papilloma virus type 1.
IN T00205 E2; BPV-1, bovine papilloma virus type 1.
IN T00752 Sp1; mouse, Mus musculus.
IN T00753 Sp1; pig, Sus scrofa.
IN T00754 Sp1; rat, Rattus norvegicus.
IN T00755 Sp1; chick, Gallus gallus.
IN T00757 Sp1; monkey, Cercopithecus aethiops.
IN T00758 Sp1; clawed frog, Xenopus.
IN T00759 Sp1; human, Homo sapiens.
IN T01228 Sp1; hamster, Cricetulus sp.
XX
MX M00107 V$E2_01.
MX M00181 V$E2_Q6.
MX M00928 V$E2_Q6_01.
XX
BS R03720.
BS R03702.
BS R03704.
BS R06658.
BS R06659.
BS R06660.
BS R06661.
BS R06662.
BS R06663.
BS R06664.
BS R06665.
BS R06666.
BS R06667.
BS R06668.
BS R06669.
BS R06670.
BS R06671.
BS R06672.
BS R06673.
BS R06674.
BS R00171.
BS R00172.
BS R00173.
BS R00174.
BS R00175.
BS R00176.
BS R00177.
BS R00178.
BS R00179.
BS R00180.
BS R00181.
BS R00182.
BS R00184.
BS R00185.
BS R00186.
BS R00187.
BS R00188.
BS R00189.
BS R00190.
BS R00191.
BS R00192.
BS R00193.
BS R04573.
BS R04678.
BS R03701.
BS R00743.
XX
DR TRANSPATH: MO000014376.
DR EMBL: M20219; PAPPPB2C.
DR EMBL: X02346;
DR EMBL: X05817; PABPV4XX.
DR UniProtKB: P03122;
DR UniProtKB: P08345; VE2_BPV4.
DR UniProtKB: P11299; VE2_BPV2.
DR PDB: 2BOP.
XX
RN [1]; RE0000237.
RX PUBMED: 1850324.
RA Li R., Knight J. D., Jackson S. P., Tijan R., Botchan M. R.
RT Direct interaction between Sp1 and the BPV Enhancer E2 protein mediates synergistic activation of transcription
RL Cell 65:493-505 (1991).
RN [2]; RE0000325.
RX PUBMED: 2835231.
RA Hawley-Nelson P., Androphy E. J., Lowy D. R., Schiller J. T.
RT The specific DNA recognition sequence of the bovine papillomavirus E2 protein is an E2-dependent enhancer
RL EMBO J. 7:525-531 (1988).
RN [3]; RE0000361.
RX PUBMED: 2850174.
RA Dostatni N., Thierry F., Yaniv M.
RT A dimer of BPV-1 E2 containing a protease resistant core interacts with its DNA target
RL EMBO J. 7:3807-3816 (1988).
RN [4]; RE0000654.
RX PUBMED: 2540059.
RA Lambert P. F., Dostatni N., McBride A. A., Yaniv M., Howley P. M., Arcangioli B.
RT Functional analysis of the papilloma virus E2 trans-activator in Saccharomyces cerevisiae
RL Genes Dev. 3:38-48 (1989).
RN [5]; RE0002268.
RX PUBMED: 2831538.
RA Moskaluk C., Bastia D.
RT DNA bending is induced in an enhancer by the DNA-binding domain of the bovine papillomavirus E2 protein
RL Proc. Natl. Acad. Sci. USA 85:1826-1830 (1988).
RN [6]; RE0002269.
RX PUBMED: 3029771.
RA Moskaluk C., Bastia D.
RT The E2 gene of bovine papillomavirus encodes an enhancer-binding protein
RL Proc. Natl. Acad. Sci. USA 84:1215-1218 (1987).
RN [7]; RE0002475.
RX PUBMED: 1849647.
RA Knight J. D., Li R., Botchan M.
RT The activation domain of the bovine papillomavirus E2 protein mediates association of DNA-bound dimers to form DNA loops
RL Proc. Natl. Acad. Sci. USA 88:3204-3208 (1991).
RN [8]; RE0002509.
RX PUBMED: 1648739.
RA Lusky M., Fontane E.
RT Formation of the complex of bovine papillomavirus E1 and E2 proteins is modulated by E2 phosphorylation and depends upon sequences within the carboxyl terminus of E1
RL Proc. Natl. Acad. Sci. USA 88:6363-6367 (1991).
RN [9]; RE0002687.
RX PUBMED: 2176744.
RA Mohr I. J., Clark R., Sun S., Androphy E. J., MacPherson P., Botchan M. R.
RT Targeting the E1 replication protein to the papillomavirus origin of replication by complex formation with the E2 transactivator
RL Science 250:1694-1699 (1990).
RN [10]; RE0006548.
RX PUBMED: 1311070.
RA Tan S. H., Gloss B., Bernard H. U.
RT During negative regulation of the human papillomavirus-16 E6 promoter, the viral E2 protein can displace Sp1 from a proximal promoter element
RL Nucleic Acids Res. 20:251-256 (1992).
XX
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