AC T00752
XX
ID T00752
XX
DT 15.10.1992 (created); ewi.
DT 22.01.2016 (updated); nes.
CO Copyright (C), QIAGEN.
XX
FA Sp1
XX
SY Sp1; Stimulating Protein 1; trans-acting transcription factor 1.
XX
OS mouse, Mus musculus
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae
XX
GE G004918 Sp1.
XX
CL C0001; CH; 2.3.1.1.1.
XX
SF 3 zinc finger motifs;
SF the three zinc fingers are necessary and sufficient for interaction with GATA-1 T00305 [12];
XX
CP 3T3-L1, 3T3-L1, differentiated [20]; Y1 cells [30]; both untreated and PDGF treated NIH3T3 cells [16]; CMT-93 [21]; Undifferentiated and Differentiated 3T3-L1 cells [22].
XX
FF During neuronal differentiation (RA treatment) of P-19 cells there is an increased level of this protein [18];
FF SP1 interacts with cyclin E, Cyclin A, and cyclin-dependent kinase 2 during the S phase [29];
FF Sp1 expression is present in undifferentiated myoblasts, but absent in differentiated myotubes [19];
FF particularly low levels in some adult organs such as liver, apparently absent in adult kidney;
FF rapidly induced by phosphorothioate oligonucleotides (irrespective of their sequence) dependent on RelA subunit of NF-kappaB [11];
FF synergy of Sp1 and GATA-1 T00305 on gene expression [12];
XX
IN T08977 ATF-3; mouse, Mus musculus.
IN T16043 BCL-6; Mammalia.
IN T00205 E2; BPV-1, bovine papilloma virus type 1.
IN T01543 E2F-1; mouse, Mus musculus.
IN T09117 E2F-1; human, Homo sapiens.
IN T09123 E2F-2; human, Homo sapiens.
IN T14606 E2F-3; human, Homo sapiens.
IN T10013 Egr-1; mouse, Mus musculus.
IN T00305 GATA-1; mouse, Mus musculus.
IN T02686 GATA-6; mouse, Mus musculus.
IN T23418 HDAC1; mouse, Mus musculus.
IN T04140 hdac2; mouse, Mus musculus.
IN T14261 LRF; Mammalia.
IN T10644 MTF-1; mouse, Mus musculus.
IN T00528 myogenin; mouse, Mus musculus.
IN T10542 p300; mouse, Mus musculus.
IN T14288 PLZF; Mammalia.
IN T05067 Smad4; mouse, Mus musculus.
IN T00752 Sp1; mouse, Mus musculus.
XX
MX M00008 V$SP1_01.
MX M01303 V$SP1_02.
MX M00933 V$SP1_Q2_01.
MX M07395 V$SP1_Q2_02.
MX M00932 V$SP1_Q4_01.
MX M00196 V$SP1_Q6.
MX M00931 V$SP1_Q6_01.
XX
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XX
DR TRANSPATH: MO000025152.
DR TRANSCOMPEL: C00132.
DR TRANSCOMPEL: C00218.
DR TRANSCOMPEL: C00221.
DR TRANSCOMPEL: C00244.
DR TRANSCOMPEL: C00273.
DR TRANSCOMPEL: C00275.
DR TRANSCOMPEL: C00359.
DR TRANSCOMPEL: C00432.
DR TRANSCOMPEL: C00453.
DR TRANSCOMPEL: C00516.
DR TRANSCOMPEL: C00524.
DR TRANSCOMPEL: C00568.
DR TRANSCOMPEL: C00570.
DR TRANSCOMPEL: C00571.
DR TRANSCOMPEL: C00573.
DR TRANSCOMPEL: C00633.
DR TRANSCOMPEL: C00642.
DR UniProtKB: O89090;
XX
RN [1]; RE0000182.
RX PUBMED: 2170018.
RA Jackson S. P., MacDonald J. J., Lees-Miller S., Tjian R.
RT GC box binding induces phosphorylation by a DNA-dependent protein kinase
RL Cell 63:155-165 (1990).
RN [2]; RE0000692.
RX PUBMED: 2163346.
RA Saffer J. D., Jackson S. P., Thurston S. J.
RT SV40 stimulates expression of the trans-acting factor Sp1 at the mRNA level
RL Genes Dev. 4:659-666 (1990).
RN [3]; RE0000693.
RX PUBMED: 1851121.
RA Su W., Jackson S., Tjian R., Echols H.
RT DNA looping between site for transcriptional activation: self-association of DNA-bound Sp1
RL Genes Dev. 5:820-826 (1991).
RN [4]; RE0001271.
RX PUBMED: 2181288.
RA Lemaigre F. P., Lafontaine D. A., Courtois S. J., Durviaux S. M., Rousseau G. G.
RT Sp1 can displace GHF-1 from its distal binding site and stimulate transcription from the growth hormone gene promoter
RL Mol. Cell. Biol. 10:1811-1814 (1990).
RN [5]; RE0001375.
RX PUBMED: 2677669.
RA Schmidt M. C., Zhou Q., Berk A. J.
RT Sp1 Activates Transcription without Enhancing DNA-Binding Activity of the TATA Box Factor
RL Mol. Cell. Biol. 9:3299-3307 (1989).
RN [6]; RE0001495.
RX PUBMED: 2005904.
RA Saffer J. D., Jackson S. P., Annarella M. B.
RT Developmental expression of Sp1 in the mouse
RL Mol. Cell. Biol. 11:2189-2199 (1991).
RN [7]; RE0001631.
RX PUBMED: 1710025.
RA Pecorino L. T., Darrow A. L., Strickland S.
RT In vitro analysis of the tissue plasminogen activator promoter reveals a GC box-binding activity present in murine brain but undetectable in kidney and liver
RL Mol. Cell. Biol. 11:3139-3147 (1991).
RN [8]; RE0002175.
RX PUBMED: 1886769.
RA Somma M. P., Gambino I., Lavia P.
RT Transcription factors binding to the mouse HTF9 housekeeping promoter differ between cell types
RL Nucleic Acids Res. 19:4451-4458 (1991).
RN [9]; RE0002618.
RX PUBMED: 3103216.
RA Seguin C., Hamer D. H.
RT Regulation in Vitro of Metallothionein Gene Binding Factors
RL Science 235:1383-1387 (1987).
RN [10]; RE0002766.
RX PUBMED: 2325642.
RA Hirsch M.-R., Gaugler L., Deagostini-Bazin H., Bally-Cuif L., Goridis C.
RT Identification of Positive and Negative Regulatory Elements Governing Cell-Type-Specific Expression of the Neural Cell Adhesion Molecule Gene
RL Mol. Cell. Biol. 10:1959-1968 (1990).
RN [11]; RE0006719.
RX PUBMED: 8016096.
RA Perez J. R., Li Y., Stein C. A., Majumder S., van Oorschot A.
RT Sequence-independent induction of Sp1 trasncription factor activity by phosphorothioate oligodeoxynucleotides
RL Proc. Natl. Acad. Sci. USA 91:5957-5961 (1994).
RN [12]; RE0010577.
RX PUBMED: 7739528.
RA Merika M., Orkin S. H.
RT Functional synergy and physical interactions of the erythroid transcription factor GATA-1 with the Krueppel family proteins Sp1 and EKLF
RL Mol. Cell. Biol. 15:2437-2447 (1995).
RN [13]; RE0012787.
RX PUBMED: 8657141.
RA Karlseder J., Rotheneder H., Wintersberger E.
RT Interaction of Sp1 with the growth- and cell cycle regulated transcription factor E2F
RL Mol. Cell. Biol. 16:1659-1667 (1996).
RN [14]; RE0016556.
RX PUBMED: 2123467.
RA Sartorelli V., Webster K. A., Kedes L.
RT Muscle-specific expression of the cardiac alpha-actin gene requires MyoD, CArG-box binding factor, and Sp1.
RL Genes Dev. 4:1811-1822 (1990).
RN [15]; RE0028908.
RX PUBMED: 9819371.
RA Srivastava S., Weitzmann M. N., Kimble R. B., Rizzo M., Zahner M., Milbrandt J., Ross F. P., Pacifici R.
RT Estrogen blocks M-CSF gene expression and osteoclast formation by regulating phosphorylation of Egr-1 and its interaction with Sp-1.
RL J. Clin. Invest. 102:1850-9 (1998).
RN [16]; RE0045347.
RX PUBMED: 11511524.
RA Maehara K., Oh-Hashi K., Isobe K. i.
RT Early growth-responsive-1-dependent manganese superoxide dismutase gene transcription mediated by platelet-derived growth factor
RL FASEB J. 15:2025-6 (2001).
RN [17]; RE0049019.
RX PUBMED: 12569082.
RA Zhang X., Liu Y.
RT Suppression of HGF receptor gene expression by oxidative stress is mediated through the interplay between Sp1 and Egr-1.
RL Am. J. Physiol. Renal Physiol. 284:F1216-25 (2003).
RN [18]; RE0050179.
RX PUBMED: 14970236.
RA Liu A., Hoffman P. W., Lu W., Bai G.
RT NF-kappaB site interacts with Sp factors and up-regulates the NR1 promoter during neuronal differentiation.
RL J. Biol. Chem. 279:17449-17458 (2004).
RN [19]; RE0050240.
RX PUBMED: 15550398.
RA de Leon M. B., Montanez C., Gomez P., Morales-Lazaro S. L., Tapia-Ramirez V., Valadez-Graham V., Recillas-Targa F., Yaffe D., Nudel U., Cisneros B.
RT Dystrophin Dp71 expression is down-regulated during myogenesis: role of Sp1 and Sp3 on the Dp71 promoter activity.
RL J. Biol. Chem. 280:5290-5299 (2005).
RN [20]; RE0050750.
RX PUBMED: 16394508.
RA Wada T., Shimba S., Tezuka M.
RT Transcriptional regulation of the hypoxia inducible factor-2alpha (HIF-2alpha) gene during adipose differentiation in 3T3-L1 cells.
RL Biol. Pharm. Bull. 29:49-54 (2006).
RN [21]; RE0052176.
RX PUBMED: 14570593.
RA Jonckheere N., van der Sluis M., Velghe A., Buisine M. P., Sutmuller M., Ducourouble M. P., Pigny P., Buller H. A., Aubert J. P., Einerhand A. W., Van Seuningen I.
RT Transcriptional activation of the murine Muc5ac mucin gene in epithelial cancer cells by TGF-beta/Smad4 signalling pathway is potentiated by Sp1.
RL Biochem. J. 377:797-808 (2004).
RN [22]; RE0053760.
RX PUBMED: 16923809.
RA Nichol D., Christian M., Steel J. H., White R., Parker M. G.
RT RIP140 expression is stimulated by estrogen-related receptor alpha during adipogenesis.
RL J. Biol. Chem. 281:32140-32147 (2006).
RN [23]; RE0063003.
RX PUBMED: 12004059.
RA Lee D. K., Suh D., Edenberg H. J., Hur M. W.
RT POZ domain transcription factor, FBI-1, represses transcription of ADH5/FDH by interacting with the zinc finger and interfering with DNA binding activity of Sp1.
RL J. Biol. Chem. 277:26761-26768 (2002).
RN [24]; RE0063616.
RX PUBMED: 18793716.
RA Harris S. M., Harvey E. J., Hughes T. R., Ramji D. P.
RT The interferon-gamma-mediated inhibition of lipoprotein lipase gene transcription in macrophages involves casein kinase 2- and phosphoinositide-3-kinase-mediated regulation of transcription factors Sp1 and Sp3.
RL Cell. Signal. 20:2296-2301 (2008).
RN [25]; RE0065005.
RX PUBMED: 18192274.
RA Kiryu-Seo S., Kato R., Ogawa T., Nakagomi S., Nagata K., Kiyama H.
RT Neuronal injury-inducible gene is synergistically regulated by ATF3, c-Jun, and STAT3 through the interaction with Sp1 in damaged neurons.
RL J. Biol. Chem. 283:6988-6996 (2008).
RN [26]; RE0065693.
RX PUBMED: 18768929.
RA Zhou B., Francis T. A., Yang H., Tseng W., Zhong Q., Frenkel B., Morrisey E. E., Ann D. K., Minoo P., Crandall E. D., Borok Z.
RT GATA-6 mediates transcriptional activation of aquaporin-5 through interactions with Sp1.
RL Am. J. Physiol. Cell Physiol. 295:C1141-50 (2008).
RN [27]; RE0068516.
RX PUBMED: 20833840.
RA Maeda K., Nishiyama C., Ogawa H., Okumura K.
RT GATA2 and Sp1 positively regulate the c-kit promoter in mast cells.
RL J. Immunol. 185:4252-4260 (2010).
RN [28]; RE0068959.
RX PUBMED: 19420113.
RA Yu Z., Li M., Zhang D., Xu W., Kone B. C.
RT Sp1 trans-activates the murine H(+)-K(+)-ATPase alpha(2)-subunit gene.
RL Am. J. Physiol. Renal Physiol. 297:F63-70 (2009).
RN [29]; RE0031392.
RX PUBMED: 12794070.
RA Banchio C., Schang L. M., Vance D. E.
RT Activation of CTP:phosphocholine cytidylyltransferase alpha expression during the S phase of the cell cycle is mediated by the transcription factor Sp1.
RL J. Biol. Chem. 278:32457-64 (2003).
RN [30]; RE0052101.
RX PUBMED: 10383457.
RA Ahlgren R., Suske G., Waterman M. R., Lund J.
RT Role of Sp1 in cAMP-dependent transcriptional regulation of the bovine CYP11A gene.
RL J. Biol. Chem. 274:19422-19428 (1999).
XX
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