AC T10644
XX
ID T10644
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DT 17.07.2007 (created); nta.
DT 06.11.2014 (updated); pro.
CO Copyright (C), QIAGEN.
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FA MTF-1
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SY MEP-1; metal element protein-1; metal-regulatory transcription factor 1; MTF-1.
XX
OS mouse, Mus musculus
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae
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GE G009179 Mtf1.
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CL C0001; CH.
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SZ 675 AA; 72.6 kDa (cDNA) (calc.), 100 kDa (SDS) [5]
XX
SQ MGEHSPDDNIIFFKGEEDDLTPHDKMLRFVDDNGLVPSSSGTVYDRTTVLIEQDPGTLED
SQ DEDDGQCGEPLPFLVEGEEGFLIDQEAMSQGYVQHIISPDQIHLTINPGSTPMPRNIEGA
SQ TLTLQSECPETKRKEVKRYQCTFEGCPRTYSTAGNLRTHQKTHRGEYTFVCNQEGCGKAF
SQ LTSYSLRIHVRVHTKEKPFECDVQGCEKAFNTLYRLKAHQRLHTGKTFNCESQGCSKYFT
SQ TLSDLRKHIRTHTGEKPFRCDHDGCGKAFAASHHLKTHVRTHTGERPFFCPSNGCEKTFS
SQ TQYSLKSHMKGHDNKGTAYSALPQHNGSEDTNHSLYLSELGLLSTDSELQENSSSTQDQD
SQ LSTISPAIIFESMFQNSDDPGIQDDPLQTAALIDSFNGDAESVIDVPPPAGNSASLSLPL
SQ VLQSGISEPPQPLLPATAPSAPPPAPSLGPGSQPAAFGSPPALLQPPEVPVPHSTQFAAN
SQ HQEFLPHPQAPPQTIVPGLSVVAGAPASAATVASAVAAPAPPQSTTEPLPAMVQTLPLGA
SQ NSVLTNNPTITITPTPNTAILQSSLVMGEQNLQWILNGATSSPQNQEQIQQASKVEQVYF
SQ ATTVPVASGTGSSVQQIGLSVPVIIIKQEEACQCQCACRDSAKERAAGRRKGCSSPPPPE
SQ PNPQPPDGPSLQLPP
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SC Swiss-Prot#Q07243
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FT 25 651 
PF00478; IMP dehydrogenase / GMP reductase domain.
FT 139 163 
PF00096; zf-C2H2.
FT 139 163 
SM00355; c2h2final6.
FT 139 168 
PS50157; ZINC_FINGER_C2H2_2.
FT 169 193 
PF00096; zf-C2H2.
FT 169 193 
SM00355; c2h2final6.
FT 169 198 
PS50157; ZINC_FINGER_C2H2_2.
FT 199 223 
PF00096; zf-C2H2.
FT 199 223 
SM00355; c2h2final6.
FT 199 228 
PS50157; ZINC_FINGER_C2H2_2.
FT 228 252 PF00096; zf-C2H2.
FT 228 252 SM00355; c2h2final6.
FT 228 257 PS50157; ZINC_FINGER_C2H2_2.
FT 258 282 PF00096; zf-C2H2.
FT 258 282 SM00355; c2h2final6.
FT 258 287 PS50157; ZINC_FINGER_C2H2_2.
FT 288 312 PF00096; zf-C2H2.
FT 288 312 SM00355; c2h2final6.
FT 288 317 PS50157; ZINC_FINGER_C2H2_2.
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IN T01318 CBP; mouse, Mus musculus.
IN T10542 p300; mouse, Mus musculus.
IN T00752 Sp1; mouse, Mus musculus.
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MX M01242 V$MTF1_01.
MX M01243 V$MTF1_02.
MX M02778 V$MTF1_05.
MX M00650 V$MTF1_Q4.
MX M04619 V$MTF1_Q5.
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BS R04850.
BS R04851.
BS R64710.
BS R01022.
BS R29573.
BS R21283.
BS R21284.
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DR TRANSPATH: MO000110815.
DR EMBL: X71327; MMMTF1.
DR UniProtKB: Q07243; MTF1_MOUSE.
XX
RN [1]; RE0000683.
RX PUBMED: 3371659.
RA Mueller P. R., Salser S. J., Wold B.
RT Constitutive and metal-inducible protein: DNA interactions at the mouse metallothionein I promoter examined by in in vivo and in vitro footprinting
RL Genes Dev. 2:412-427 (1988).
RN [2]; RE0001482.
RX PUBMED: 2725504.
RA Culotta V. C., Hamer D. H.
RT Fine mapping of a mouse metallothionein gene metal response element
RL Mol. Cell. Biol. 9:1376-1380 (1989).
RN [3]; RE0002180.
RX PUBMED: 1870976.
RA Labbe S., Prevost J., Remondelli P., Leone A., Seguin C.
RT A nuclear factor binds to the metal regulatory elements of the mouse gene encoding metallothionein-I
RL Nucleic Acids Res. 19:4225-4231 (1991).
RN [4]; RE0006649.
RX PUBMED: 8065932.
RA Brugnera E., Georgiev O., Radtke F., Heuchel R., Baker E., Sutherland G. R., Schaffner W.
RT Cloning, chromosomal mapping and characterization of the human metal-regulatory transcription factor MTF-1
RL Nucleic Acids Res. 22:3167- 3173 (1994).
RN [5]; RE0006650.
RX PUBMED: 8467794.
RA Radtke F., Heuchel R., Georgiev O., Hergersberg M., Gariglio M., Dembic Z., Schaffner W.
RT Cloned transcription factor MTF-1 activates the mouse metallothionein I promoter
RL EMBO J. 12:1355-1362 (1993).
RN [6]; RE0006706.
RX PUBMED: 8026472.
RA Heuchel R., Radtke F., Georgiev O., Stark G., Aguet M., Schaffner W.
RT The transcription factor MTF-1 is essential for basal and heavy metal-induced metallothionein gene expression
RL EMBO J. 13:2870-2875 (1994).
RN [7]; RE0006723.
RX PUBMED: 8108390.
RA Palmiter R. D.
RT Regulation of metallothionein genes by heavy metals appers to be mediated by a zinc-sensitive inhibitor that interacts with a contstitutively active transcription factor, MTF-1
RL Proc. Natl. Acad. Sci. USA 91:1219- 1223 (1994).
RN [8]; RE0006724.
RX PUBMED: 7610056.
RA Radtke F., Georgiev O., Muller H.-P., Brugnera E., Schaffner W.
RT Functional domains of the heavy metal-responsive transcription regulator MTF-1
RL Nucleic Acids Res. 23:2277-2286 (1995).
RN [9]; RE0007200.
RX PUBMED: 8479904.
RA Labbe S., Larouche L., Mailhot D., Seguin C.
RT Purification of mouse MEP-1, a nuclear protein which binds to the metal regulatory elements of genes encoding metallothionein
RL Nucleic Acids Res. 21:1549-1554 (1993).
RN [10]; RE0013733.
RX PUBMED: 9582278.
RA Guenes C., Heuchel R., Georgiev O., Muller K.-H., Lichtlen P., Bluthmann H., Marino S., Aguzzi A., Schaffner W.
RT Embryonic lethality and liver degeneration in mice lacking the metal-responsive transcriptional activator MTF-1.
RL EMBO J. 17:2846-2854 (1998).
RN [11]; RE0013734.
RX PUBMED: 8824273.
RA Dalton T. P., Li Q., Bittel D., Liang L., Andrews G. K.
RT Oxidative stress activates metal-responsive transcription factor-1 binding activity. Occupancy in vivo of metal response elements in the metallothionein-I gene promoter.
RL J. Biol. Chem. 271:26233-26241 (1996).
RN [12]; RE0013735.
RX PUBMED: 10096565.
RA Murphy B. J., Andrews G. K., Bittel D., Discher D. J., McCue J., Green C. J., Yanovsky M., Giaccia A., Sutherland R. M., Laderoute K. R., Webster K. A.
RT Activation of metallothionein gene expression by hypoxia involves metal response elements and metal transcription factor-1.
RL Cancer Res. 59:1315-1322 (1999).
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