AC T10028
XX
ID T10028
XX
DT 20.12.2006 (created); apk.
DT 04.11.2014 (updated); asv.
CO Copyright (C), QIAGEN.
XX
FA SREBP-1c
XX
OS rat, Rattus norvegicus
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae
XX
GE G009061 Srebf1.
XX
CL C0012; bHLH-ZIP.
XX
SZ 1110 AA; 118.0 kDa (cDNA) (calc.).
XX
SQ MDCTFEDMLQLINNQDSDFPGLFDAPYAGGETGDTGPSSPGASSPESFSSPASLGSSLEA
SQ FLGGPKVTPAPLSPPPSAPTAVKMYPSVPPFSPGPGIKEEPVPLTILQPPAPQPSPGTLL
SQ PPSFPPPPVQLSPAPVLGYSSLPSGFSGTLPGNTQQTPSSLPLGSTPGISPTPLHTQVQS
SQ SAAQQPPPASAAPRMSTVASQIQQVPVVLQPHFIKADSLLLTAVKTDTGATMKTAGINTL
SQ APGTAVQAGPLQTLVSGGTILATVPLVVDTDKLPIHRLAAGGKALGSAQSRGEKRTAHNA
SQ IEKRYRSSINDKIVELKDLVVGTEAKLNKSAVLRKAIDYIRFLQHSNQKLKQENLTLRSA
SQ HKSKSLKDLVSACGSGGGTDVSMEGMKPEVVETLTPPPSDAGSPSQSSPLSLGSRGSSSG
SQ GSDSEPDSPAFEDNQVKAQRLPSHSRGMLDRSRLALCVLVFLCLTCNPLASLFGWGILTP
SQ SDASGVHRSSGRSMLEAESRDGSNWTQWLLPPLVWLANGLLVLACLALLFVYGEPVTRPH
SQ SGPAVHFWRHRKQADLDLARGDFAQAAQQLWLALQALGRPLPTSNLDLACSLLWNLVRHL
SQ LQRLWVGRWLAGQAGGLQRDYRLRKDARASARDAAVVYHKLHQLHAMGKYTGGHLVASNL
SQ ALSALNLAECAGDAISMATLAEIYVAAALRVKTSLPRALHFLTRFFLSSARQACLAQSGA
SQ VPLAMQWLCHPVGHRFFVDGDWAVHGAPQESLYSVAGNPVDPLAQVTRLFCEHLLERALN
SQ CIAQPSPGAADGDREFSDALGYLQLLNSCSDAVGAPACSFSVSSSMATTTGTDPVAKWWA
SQ SLTAVVIHWLRRDEEAAERLYPLVEHIPQVLQETERPLPRAALYSFKAARALLDHRKVES
SQ SPASLAICEKASGYLRDSLASTSTASSIDKAMQLLLCDLLLVARTSLWRRQQSAASAQGA
SQ HGTSNGPQASALELRGFQHDLSSLRRLAQSFRPAMRRVFLHEATARLMAGASPARTHQLL
SQ DRSLRRRAGSSGKGGAAAELEPRPTWREHTEALLLASCYLPPAFLSAPGQRVSMLAEAAR
SQ TVEKLGDHRLLLDCQQMLLRLGGGTTVTSS
XX
SC Swiss-Prot#P56720-1
XX
SF at least two isoforms are known: SREBP-1c (this entry) and SREBP-1a;
XX
IN T15694 Id2; Mammalia.
IN T00754 Sp1; rat, Rattus norvegicus.
IN T00759 Sp1; human, Homo sapiens.
XX
MX M00220 V$SREBP1_01.
MX M00221 V$SREBP1_02.
MX M01173 V$SREBP1_Q5.
MX M00749 V$SREBP1_Q6.
MX M04632 V$SREBP1_Q6_01.
MX M00776 V$SREBP_Q3.
MX M01168 V$SREBP_Q6.
XX
BS R07517.
BS R07518.
BS R07519.
BS R07520.
BS R07521.
BS R07522.
BS R07523.
BS R04416.
BS R04417.
BS R21206.
BS R30480.
BS R16489.
BS R19438.
BS R38736.
BS R60997.
BS R64678.
BS R31498.
BS R61311.
BS R61312.
BS R61313.
XX
DR TRANSPATH: MO000095089.
DR EMBL: AF286470; AF286470.
DR EMBL: L16995;
DR UniProtKB: P56720-1;
XX
RN [1]; RE0003438.
RX PUBMED: 8336713.
RA Kim J., Tontonoz P., Spiegelman B.
RT ADD: a novel helix-loop-helix protein associated with adipocyte determination and differentiation
RL Mol. Cell. Biol. 13:4753-4759 (1993).
RN [2]; RE0003451.
RX PUBMED: 7739539.
RA Kim J. B., Spotts G. D., Halvorsen Y.-D., Shih H.-M., Ellenberger T., Towle H. C., Spiegelman B. M.
RT Dual DNA binding specificity of ADD1/SREBP1 controlled by a single amino acid in the basic helix-loop-helix domain
RL Mol. Cell. Biol. 15:2582-2588 (1995).
RN [3]; RE0023599.
RX PUBMED: 11171976.
RA DeBose-Boyd R. A., Ou J., Goldstein J. L., Brown M. S.
RT Expression of sterol regulatory element-binding protein 1c (SREBP-1c) mRNA in rat hepatoma cells requires endogenous LXR ligands.
RL Proc. Natl. Acad. Sci. USA 98:1477-1482 (2001).
RN [4]; RE0052791.
RX PUBMED: 17449871.
RA Deng X., Yellaturu C., Cagen L., Wilcox H. G., Park E. A., Raghow R., Elam M. B.
RT Expression of the rat sterol regulatory element-binding protein-1c gene in response to insulin is mediated by increased transactivating capacity of specificity protein 1 (Sp1).
RL J. Biol. Chem. 282:17517-17529 (2007).
RN [5]; RE0066027.
RX PUBMED: 19158095.
RA Yellaturu C. R., Deng X., Cagen L. M., Wilcox H. G., Mansbach CM 2. n. d., Siddiqi S. A., Park E. A., Raghow R., Elam M. B.
RT Insulin enhances post-translational processing of nascent SREBP-1c by promoting its phosphorylation and association with COPII vesicles.
RL J. Biol. Chem. 284:7518-7532 (2009).
RN [6]; RE0066057.
RX PUBMED: 19759400.
RA Yellaturu C. R., Deng X., Park E. A., Raghow R., Elam M. B.
RT Insulin enhances the biogenesis of nuclear sterol regulatory element-binding protein (SREBP)-1c by posttranscriptional down-regulation of Insig-2A and its dissociation from SREBP cleavage-activating protein (SCAP).SREBP-1c complex.
RL J. Biol. Chem. 284:31726-31734 (2009).
XX
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