AC T00149
XX
ID T00149
XX
DT 15.10.1992 (created); ewi.
DT 29.01.2016 (updated); mkl.
CO Copyright (C), QIAGEN.
XX
FA COUP-TF1
XX
SY chicken ovalbumin upstream promoter transcription factor; Chicken Ovalbumin UPstream transcription factor; COUP; COUP-alpha; COUP-TF; EAR3; NR2F1.
XX
OS human, Homo sapiens
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; primates
XX
GE G004659 NR2F1; HGNC: NR2F1.
XX
CL C0002; CC (rec); 2.1.3.5.1.
XX
CP (HeLa).
XX
FF repressor;
FF represses RXR-mediated activation and retinoic acid responses;
FF also antagonizes HNF-4-mediated activation [12] [11];
FF competitively binds to XRE with AhR:Arnt heterodimer [15];
XX
IN T01795 AhR; human, Homo sapiens.
IN T00261 ER-alpha; human, Homo sapiens.
IN T04687 NCOR1; human, Homo sapiens.
IN T17026 RNF96; human, Homo sapiens.
IN T01331 RXR-alpha; mouse, Mus musculus.
IN T01345 RXR-alpha; human, Homo sapiens.
IN T01359 RXR-alpha; clawed frog, Xenopus laevis.
XX
MX M00765 V$COUPDR1_Q6.
MX M03542 V$COUPTF1_Q6_01.
MX M01036 V$COUPTF_Q6.
MX M00158 V$COUP_01.
MX M00762 V$DR1_Q3.
MX M00965 V$DR4_Q2.
MX M00967 V$HNF4_Q6.
MX M07280 V$NR1NR2_Q3.
MX M04474 V$NR2F1_04.
MX M08016 V$NR2F1_05.
XX
BS R13348.
BS R04591.
BS R03405.
BS R03406.
BS R00135.
BS R20457.
BS R24217.
BS R24215.
BS R73921.
BS R15902.
BS R15904.
BS R20399.
BS R20939.
BS R20945.
BS R16929.
BS R00912.
BS R00911.
BS R03931.
XX
DR TRANSPATH: MO000024736.
DR TRANSCOMPEL: C00124.
DR TRANSCOMPEL: C00125.
DR TRANSCOMPEL: C00398.
DR UniProtKB: P10589;
XX
RN [1]; RE0000118.
RX PUBMED: 3040258.
RA Tsai S. Y., Sagami I., Wang H., Tsai M.-J., O'Malley B. W.
RT Interaction between a DNA-Binding Transcription Factor (COUP) and a Non-DNA Binding Factor (S300-II)
RL Cell 50:701-709 (1987).
RN [2]; RE0000853.
RX PUBMED: 3047126.
RA Hwung Y.-P., Wang L.-H., Tsai S. Y., Tsai M.-J.
RT Differential Binding of the Chicken Ovalbumin Upstream Promoter (COUP) Transcription Factor to Two Different Promoters
RL J. Biol. Chem. 263:13470-13474 (1988).
RN [3]; RE0000873.
RX PUBMED: 3680243.
RA Wang L.-H., Tsai S. Y., Sagami I., Tsai M.-J., O'Malley B. W.
RT Purification and Characterization of Chicken Ovalbumin Upstream Promoter Transcription Factor from HeLa Cells
RL J. Biol. Chem. 262:16080-16086 (1987).
RN [4]; RE0001172.
RX PUBMED: 2033658.
RA Cooney A. J., Tsai S. Y., O'Malley B. W., Tsai M.-J.
RT Chicken ovalbumin upstream promoter transcription factor binds to a negative regulatory region in the human immunodeficiency virus type 1 long terminal repeat
RL J. Virol. 65:2853-2860 (1991).
RN [5]; RE0001323.
RX PUBMED: 3796602.
RA Sagami I., Tsai S. Y., Wang H., Tsai M.-J., O'Malley B. W.
RT Identification of Two Factors Required for Transcription of the Ovalbumin Gene
RL Mol. Cell. Biol. 6:4259-4267 (1986).
RN [6]; RE0001324.
RX PUBMED: 3785213.
RA Pastorcic M., Wang H., Elbrecht A., Tsai S. Y., Tsai M.-J., O'Malley B. W.
RT Control of transcription initiation in vitro requires binding of a transcription factor to the distal promoter of the ovalbumin gene
RL Mol. Cell. Biol. 6:2784-2791 (1986).
RN [7]; RE0001752.
RX PUBMED: 2172797.
RA Forman B. M., Samuels H. H.
RT Interactions among a subfamily of nuclear hormone receptors: the regulatory zipper model
RL Mol. Endocrinol. 4:1293-1301 (1990).
RN [8]; RE0002075.
RX PUBMED: 1975094.
RA de Verneuil H., Metzger D.
RT The lack of transcriptional activation of the v-erbA oncogene is in part due to a mutation in the DNA binding domain of the protein
RL Nucleic Acids Res. 18:4489-4497 (1990).
RN [9]; RE0002571.
RX PUBMED: 1311101.
RA Kliewer S. A., Umesono K., Heyman R. A., Mangelsdorf D. J., Dyck J. A., Evans R. M.
RT Retinoid X receptor COUP-TF interactions modulate retinoic acid signaling
RL Proc. Natl. Acad. Sci. USA 89:1448-1452 (1992).
RN [10]; RE0002994.
RX PUBMED: 1328857.
RA Tran P., Zhang X.-K., Salbert G., Hermann T., Lehmann J. M., Pfahl M.
RT COUP orphan receptors are negative regulators of retinoic acid response pathways
RL Mol. Cell. Biol. 12:4666-4676 (1992).
RN [11]; RE0003072.
RX PUBMED: 1312668.
RA Mietus-Snyder M., Sladek F. M., Ginsburg G. S., Kuo C. F., Ladias J. A. A., Darnell jr J. E., Karathanasis S. K.
RT Antagonism between apolipoprotein AI regulatory protein 1, Ear3/COUP-TF, and hepatocyte nuclear factor 4 modulates apolipoprotein CIII gene expression in liver and intestinal cells
RL Mol. Cell. Biol. 12:1708-1718 (1992).
RN [12]; RE0010509.
RX PUBMED: 7891708.
RA Galson D. L., Tsuchiya T., Tendler D. S., Huang L. E., Ren Y., Ogura T., Bunn H. F.
RT The orphan receptor hepatic nuclear factor 4 functions as a transcriptional activator for tissue-specific and hypoxia-specific erythropoietin gene expression and is antagonized by EAR3/COUP-TF1
RL Mol. Cell. Biol. 15:2135-2144 (1995).
RN [13]; RE0013625.
RX PUBMED: 10219237.
RA Nuclear Receptors Nomenclature Committee.
RT A unified nomenclature system for the nuclear receptor superfamily
RL Cell 97:161-163 (1999).
RN [14]; RE0013627.
RX PUBMED: 2905047.
RA Miyajima N., Kadowaki Y., Fukushige S., Shimizu S., Semba K., Yamanashi Y., Matsubara K., Toyoshima K., Yamamoto T.
RT Identification of two novel members of erbA superfamily by molecular cloning: the gene products of the two are highly related to each other
RL Nucleic Acids Res. 16:11057-11074 (1988).
RN [15]; RE0022571.
RX PUBMED: 10620335.
RA Klinge C. M., Kaur K., Swanson H. I.
RT The aryl hydrocarbon receptor interacts with estrogen receptor alpha and orphan receptors COUP-TFI and ERRalpha1.
RL Arch. Biochem. Biophys. 373:163-174 (2000).
RN [16]; RE0054989.
RX PUBMED: 15604093.
RA Albers M., Kranz H., Kober I., Kaiser C., Klink M., Suckow J., Kern R., Koegl M.
RT Automated yeast two-hybrid screening for nuclear receptor-interacting proteins.
RL Mol. Cell. Proteomics 4:205-213 (2005).
RN [17]; RE0074383.
RX PUBMED: 19112178.
RA Zhang L. J., Liu X., Gafken P. R., Kioussi C., Leid M.
RT A chicken ovalbumin upstream promoter transcription factor I (COUP-TFI) complex represses expression of the gene encoding tumor necrosis factor alpha-induced protein 8 (TNFAIP8).
RL J. Biol. Chem. 284:6156-6168 (2009).
XX
//