AC T02720
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ID T02720
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DT 04.05.1999 (created); ewi.
DT 20.06.2016 (updated); nes.
CO Copyright (C), QIAGEN.
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FA BMAL1
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SY ARNTL; Aryl hydrocarbon receptor nuclear translocator-like protein 1; BMAL1; brain and muscle arnt-like 1; member of PAS superfamily 3.
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OS human, Homo sapiens
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; primates
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GE G004706 ARNTL; HGNC: ARNTL.
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CL C0010; bHLH; 1.2.5.2.3.
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SF contains PER-ARNT-SIM (PAS) domains [3];
SF no interaction with Arnt [1];
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CP vascular smooth muscle cells [4].
EX brain,,,adult; high; Northern blot; mRNA (poly-A); [1].
EX heart,,,adult; none; Northern blot; mRNA (poly-A); [1].
EX kidney (right and left),,,adult; very low; Northern blot; mRNA (poly-A); [1].
EX liver,,,adult; none; Northern blot; mRNA (poly-A); [1].
EX lung (right and left),,,adult; very low; Northern blot; mRNA (poly-A); [1].
EX muscles,,,adult; high; Northern blot; mRNA (poly-A); [1].
EX pancreas,,,adult; none; Northern blot; mRNA (poly-A); [1].
EX placenta,,,adult; none; Northern blot; mRNA (poly-A); [1].
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IN T01795 AhR; human, Homo sapiens.
IN T10260 CLOCK; human, Homo sapiens.
IN T18364 Clock; Mammalia.
IN T01610 HIF-1alpha; human, Homo sapiens.
IN T00992 Hsp90; human, Homo sapiens.
IN T04909 MOP4; human, Homo sapiens.
IN T11196 MOP4; human, Homo sapiens.
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MX M08868 V$ARNTLIKE_Q6.
MX M07350 V$BMAL1_Q6.
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BS R73687.
BS R18528.
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DR TRANSPATH: MO000026696.
DR UniProtKB: O00327;
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RN [1]; RE0013592.
RX PUBMED: 9079689.
RA Hogenesch J. B., Chan W. K., Jackiw V. H., Brown R. C., Gu Y.-Z., Pray-Grant M., Perdew G. H., Bradfield C. A.
RT Characterization of a subset of the basic-helix-loop-helix-PAS superfamily that interacts with components of the dioxin signaling pathway
RL J. Biol. Chem. 272:8581-8593 (1997).
RN [2]; RE0013595.
RX PUBMED: 9144434.
RA Ikeda M., Nomura M.
RT cDNA cloning and tissue-specific expression of a novel basic helix-loop-helix/PAS protein (BMAL1) and identification of alternatively spliced variants with alternative translation initiation site usage
RL Biochem. Biophys. Res. Commun. 233:258-264 (1997).
RN [3]; RE0035593.
RX PUBMED: 12055078.
RA Schoenhard J. A., Eren M., Johnson C. H., Vaughan D. E.
RT Alternative splicing yields novel BMAL2 variants: tissue distribution and functional characterization.
RL Am. J. Physiol. Cell Physiol. 283:C103-14 (2002).
RN [4]; RE0081439.
RX PUBMED: 11439184.
RA McNamara P., Seo S. B., Rudic R. D., Sehgal A., Chakravarti D., Fitzgerald G. A.
RT Regulation of CLOCK and MOP4 by nuclear hormone receptors in the vasculature: a humoral mechanism to reset a peripheral clock.
RL Cell 105:877-889 (2001).
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