TRANSFAC FACTOR TABLE, Release 2017.2 - public - 2017-06-30, (C) QIAGEN

AC T02720 XX ID T02720 XX DT 04.05.1999 (created); ewi. DT 20.06.2016 (updated); nes. CO Copyright (C), QIAGEN. XX FA BMAL1 XX SY ARNTL; Aryl hydrocarbon receptor nuclear translocator-like protein 1; BMAL1; brain and muscle arnt-like 1; member of PAS superfamily 3. XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; primates XX GE G004706 ARNTL; HGNC: ARNTL. XX CL C0010; bHLH; XX SF contains PER-ARNT-SIM (PAS) domains [3]; SF no interaction with Arnt [1]; XX CP vascular smooth muscle cells [4]. EX brain,,,adult; high; Northern blot; mRNA (poly-A); [1]. EX heart,,,adult; none; Northern blot; mRNA (poly-A); [1]. EX kidney (right and left),,,adult; very low; Northern blot; mRNA (poly-A); [1]. EX liver,,,adult; none; Northern blot; mRNA (poly-A); [1]. EX lung (right and left),,,adult; very low; Northern blot; mRNA (poly-A); [1]. EX muscles,,,adult; high; Northern blot; mRNA (poly-A); [1]. EX pancreas,,,adult; none; Northern blot; mRNA (poly-A); [1]. EX placenta,,,adult; none; Northern blot; mRNA (poly-A); [1]. XX IN T01795 AhR; human, Homo sapiens. IN T10260 CLOCK; human, Homo sapiens. IN T18364 Clock; Mammalia. IN T01610 HIF-1alpha; human, Homo sapiens. IN T00992 Hsp90; human, Homo sapiens. IN T04909 MOP4; human, Homo sapiens. IN T11196 MOP4; human, Homo sapiens. XX MX M08868 V$ARNTLIKE_Q6. MX M07350 V$BMAL1_Q6. XX BS R73687. BS R18528. XX DR TRANSPATH: MO000026696. DR UniProtKB: O00327; XX RN [1]; RE0013592. RX PUBMED: 9079689. RA Hogenesch J. B., Chan W. K., Jackiw V. H., Brown R. C., Gu Y.-Z., Pray-Grant M., Perdew G. H., Bradfield C. A. RT Characterization of a subset of the basic-helix-loop-helix-PAS superfamily that interacts with components of the dioxin signaling pathway RL J. Biol. Chem. 272:8581-8593 (1997). RN [2]; RE0013595. RX PUBMED: 9144434. RA Ikeda M., Nomura M. RT cDNA cloning and tissue-specific expression of a novel basic helix-loop-helix/PAS protein (BMAL1) and identification of alternatively spliced variants with alternative translation initiation site usage RL Biochem. Biophys. Res. Commun. 233:258-264 (1997). RN [3]; RE0035593. RX PUBMED: 12055078. RA Schoenhard J. A., Eren M., Johnson C. H., Vaughan D. E. RT Alternative splicing yields novel BMAL2 variants: tissue distribution and functional characterization. RL Am. J. Physiol. Cell Physiol. 283:C103-14 (2002). RN [4]; RE0081439. RX PUBMED: 11439184. RA McNamara P., Seo S. B., Rudic R. D., Sehgal A., Chakravarti D., Fitzgerald G. A. RT Regulation of CLOCK and MOP4 by nuclear hormone receptors in the vasculature: a humoral mechanism to reset a peripheral clock. RL Cell 105:877-889 (2001). XX //