TRANSFAC FACTOR TABLE, Release 2017.2 - public - 2017-06-30, (C) QIAGEN

AC T01610 XX ID T01610 XX DT 24.01.1996 (created); ewi. DT 04.05.2016 (updated); hna. CO Copyright (C), QIAGEN. XX FA HIF-1alpha XX SY HIF1alpha; hypoxia Induced Factor 1 alpha; hypoxia-inducible factor 1alpha; member of PAS superfamily 1; MOP1. XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; primates XX GE G003959 HIF1A; HGNC: HIF1A. XX CL C0010; bHLH; XX SF HIF-1alpha is most closely related to Sim (Drosophila); SF it possesses a PAS domain [1]; SF no interaction with Ahr [4]; XX CP expression of HIF-1alpha in normal chorionic villi obtained before 10 weeks of gestation [41]; expression in preeclampsia placentas together with hTERT [41]; T98G and U87 MG cells {after treatment with deferoxamine, cobalt chloride and under hypoxia (2% oxygen)} [17]; SK-N-BE(2) + DIP (SK-N-BE(2) neuroblastoma cell line treated with 2,2'-dipyridyl) [18]; PTEC + IL-1beta (both under normoxia and hypoxia) [19]; Human lung microvascular EC and Hep3B cells exposed to hypoxia (0% oxygen) [12]; U251 cells both under normoxia (21% oxygen) and hypoxia (1% oxygen) [20]; A-172 cells treated with SNAP (L-penicillamine) or under hypoxia (1% oxygen) [21]; NiCl2 treated HeLa cells stably expressing human APP [22]; SH-SY5Y cells under hypoxia (2% oxygen) [23]. CN no observable HIF-1alpha protein expression in placenta after 10 weeks of gestation and HIF-1alpha protein expression strongly correlated with hTERT expression [41]. EX blood,basophil granulocyte,Circulatory System & Hematopoietic System,adult; low; Northern blot; total RNA; [2]. EX blood,eosinophil granulocyte,Circulatory System & Hematopoietic System,adult; low; Northern blot; total RNA; [2]. EX blood,lymphocyte,Circulatory System & Hematopoietic System,adult; low; Northern blot; total RNA; [2]. EX blood,monocyte,Circulatory System & Hematopoietic System,adult; low; Northern blot; total RNA; [2]. EX blood,neutrophil granulocyte,Circulatory System & Hematopoietic System,adult; low; Northern blot; total RNA; [2]. EX brain,,,adult; detectable; Northern blot; RNA (undefined); [2]. EX brain,,,adult; low; Northern blot; total RNA; [2]. EX brain,,,adult; very low; Northern blot; mRNA (poly-A); [4]. EX colon,,,adult; detectable; Northern blot; RNA (undefined); [2]. EX colon,,,adult; low; Northern blot; total RNA; [2]. EX heart,,,adult; detectable; Northern blot; RNA (undefined); [2]. EX heart,,,adult; high; Northern blot; mRNA (poly-A); [4]. EX heart,,,adult; high; Northern blot; total RNA; [2]. EX kidney (right and left),,,adult; detectable; Northern blot; RNA (undefined); [2]. EX kidney (right and left),,,adult; very high; Northern blot; mRNA (poly-A); [4]. EX kidney (right and left),,,adult; very high; Northern blot; total RNA; [2]. EX liver,,,adult; detectable; Northern blot; RNA (undefined); [2]. EX liver,,,adult; high; Northern blot; total RNA; [2]. EX liver,,,adult; low; Northern blot; mRNA (poly-A); [4]. EX lung (right and left),,,adult; detectable; Northern blot; RNA (undefined); [2]. EX lung (right and left),,,adult; high; Northern blot; total RNA; [2]. EX lung (right and left),,,adult; medium; Northern blot; mRNA (poly-A); [4]. EX muscles,,,adult; detectable; Northern blot; RNA (undefined); [2]. EX muscles,,,adult; low; Northern blot; total RNA; [2]. EX muscles,,,adult; none; Northern blot; mRNA (poly-A); [4]. EX ovary (right and left),,,adult; detectable; Northern blot; RNA (undefined); [2]. EX ovary (right and left),,,adult; very high; Northern blot; total RNA; [2]. EX pancreas,,,adult; detectable; Northern blot; RNA (undefined); [2]. EX pancreas,,,adult; high; Northern blot; total RNA; [2]. EX pancreas,,,adult; very low; Northern blot; mRNA (poly-A); [4]. EX placenta,,,adult; detectable; Northern blot; RNA (undefined); [2]. EX placenta,,,adult; high; Northern blot; total RNA; [2]. EX placenta,,,adult; low; Northern blot; mRNA (poly-A); [4]. EX prostate gland,,,adult; detectable; Northern blot; RNA (undefined); [2]. EX prostate gland,,,adult; high; Northern blot; total RNA; [2]. EX small intestine,,,adult; detectable; Northern blot; RNA (undefined); [2]. EX small intestine,,,adult; low; Northern blot; total RNA; [2]. EX spleen,,,adult; detectable; Northern blot; RNA (undefined); [2]. EX spleen,,,adult; high; Northern blot; total RNA; [2]. EX testis (right and left),,,adult; detectable; Northern blot; RNA (undefined); [2]. EX testis (right and left),,,adult; very high; Northern blot; total RNA; [2]. EX thymus,,,adult; detectable; Northern blot; RNA (undefined); [2]. EX thymus,,,adult; low; Northern blot; total RNA; [2]. XX FF both HIF-1alpha and hTERT expression were increased significantly when cells were exposed to hypoxia [41]; FF Differentially regulated within human lung microvascular EC and Hep3B cells exposed to hypoxia (0% oxygen) [12]; FF Expressed under hypoxic conditions (1% O2) in neuroblastoma derived Kelly cells [16]; FF activator [3]; FF HIF-1 mediates gene responses to lowered oxygen levels (hypoxia, O2 demand exceeds supply) under which state the concentration of HIF-1alpha mRNA and protein are increased [1]; FF under normoxic conditions HIF-1alpha is rapidly degraded through the ubiquitin-dependent proteasome pathway [9]; FF HIF-1alpha competes with the ligand-activated AhR for binding to Arnt (HIF-1beta) required for gene induction [2] [8]; XX IN T01346 arnt-isoform1; human, Homo sapiens. IN T10835 arnt; human, Homo sapiens. IN T08412 beta-catenin; mouse, Mus musculus. IN T02720 BMAL1; human, Homo sapiens. IN T04074 brca1; human, Homo sapiens. IN T00133 c-Jun; human, Homo sapiens. IN T25618 Cdc6; human, Homo sapiens. IN T01488 Cdk2; human, Homo sapiens. IN T05839 DEC2; human, Homo sapiens. IN T11136 DEC2; mouse, Mus musculus. IN T00373 HNF-4alpha1; human, Homo sapiens. IN T03828 HNF-4alpha; human, Homo sapiens. IN T00992 Hsp90; human, Homo sapiens. IN T34268 mcm3; human, Homo sapiens. IN T34277 mcm7; human, Homo sapiens. IN T10759 MTA-1; human, Homo sapiens. IN T01427 p300; human, Homo sapiens. IN T21984 p300; human, Homo sapiens. IN T00671 p53; human, Homo sapiens. IN T30574 Period1; mouse, Mus musculus. IN T29721 Pkm2-isoform-M2; human, Homo sapiens. IN T30232 Pkm2; human, Homo sapiens. IN T04878 Ref-1; human, Homo sapiens. IN T08711 RelA-p65; human, Homo sapiens. IN T04096 Smad3-isoform1; human, Homo sapiens. IN T00759 Sp1; human, Homo sapiens. IN T04632 SRC-1; human, Homo sapiens. IN T01493 STAT3; human, Homo sapiens. IN T08660 YY1; human, Homo sapiens. XX MX M00976 V$AHRHIF_Q6. MX M07384 V$HIF1A_Q3. MX M07043 V$HIF1A_Q5. MX M02012 V$HIF1A_Q6. MX M00797 V$HIF1_Q3. MX M00466 V$HIF1_Q5. XX BS R37690. BS R69246. BS R66110. BS R59202. BS R59204. BS R59205. BS R61588. BS R61590. BS R66432. BS R64303. BS R31347. BS R67245. BS R68677. BS R59387. BS R65238. BS R26853. BS R34132. BS R63898. BS R58827. BS R68582. BS R72353. BS R66275. BS R66225. BS R37187. BS R66957. BS R34081. BS R30002. BS R65043. BS R65540. BS R61356. BS R61357. BS R25548. BS R25551. BS R25552. BS R37108. BS R60750. BS R60753. BS R60755. BS R22296. BS R40949. BS R40950. BS R25461. BS R25462. BS R33088. BS R33089. BS R68578. BS R10172. BS R30114. BS R59262. BS R63851. BS R28138. BS R03219. BS R24274. BS R34041. BS R37364. BS R74091. BS R61235. BS R61236. BS R60063. BS R60065. BS R70550. BS R60977. BS R60979. BS R68587. BS R62425. BS R66621. BS R66623. BS R32840. BS R61640. BS R61643. BS R61644. BS R61646. BS R42118. BS R32561. BS R66208. BS R66261. BS R60906. BS R66973. BS R71331. BS R22269. BS R56294. BS R56295. BS R72375. BS R72377. BS R72379. BS R72397. BS R72401. BS R72402. BS R72403. BS R38333. BS R59928. BS R62413. BS R62415. BS R37966. BS R60938. BS R29662. BS R60537. BS R69952. BS R69957. BS R69947. BS R69958. BS R73057. BS R73060. BS R73062. BS R73063. BS R73064. BS R73065. BS R70000. BS R69953. BS R69954. BS R32046. BS R62373. BS R55875. BS R55877. BS R55878. BS R38547. BS R38556. BS R64295. BS R28320. BS R28322. BS R62011. BS R62294. BS R55864. BS R55865. BS R61248. BS R21396. BS R22177. BS R22178. BS R57132. BS R64756. BS R22251. BS R67226. BS R67228. BS R67229. BS R13356. BS R66278. BS R31370. BS R66065. BS R56153. BS R34762. BS R62003. BS R60749. BS R64712. BS R64713. BS R66696. BS R64719. BS R64721. BS R64728. BS R26928. BS R37361. BS R13214. BS R30322. BS R30323. BS R59497. BS R66059. BS R31486. BS R67072. BS R68460. BS R68756. BS R68757. BS R66317. BS R30348. BS R10395. BS R10350. BS R30326. BS R60855. BS R42172. BS R41508. BS R41510. BS R66025. BS R28527. BS R28597. BS R64317. BS R64318. BS R59253. BS R59258. BS R57422. BS R10227. BS R62005. BS R66027. BS R28141. BS R30398. BS R65544. BS R66410. BS R66411. BS R66068. BS R61889. BS R61230. BS R61231. BS R61232. BS R63070. BS R34092. BS R56138. BS R22208. BS R37848. BS R32375. BS R65271. BS R66222. BS R31523. BS R62890. BS R62892. XX DR TRANSPATH: MO000025800. DR TRANSCOMPEL: C00370. DR TRANSCOMPEL: C00371. DR TRANSCOMPEL: C00539. DR UniProtKB: Q16665; XX RN [1]; RE0003597. RX PUBMED: 7539918. RA Wang G. L., Jiang B.-H., Rue E. A., Semenza G. L. RT Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tension RL Proc. Natl. Acad. Sci. USA 92:5510-5514 (1995). RN [2]; RE0013068. RX PUBMED: 8816435. RA Gradin K., Guire J., Wenger R. H., Kvietikova I., Whitelaw M. L., Toftgard R., Tora L., Gassmann M., Poellinger L. RT Functional interference between hypoxia and dioxin signal transduction pathways: competition for recruitment of the Arnt transcription factor RL Mol. Cell. Biol. 16:5221-5231 (1996). RN [3]; RE0013520. RX PUBMED: 9000051. RA Tian H., McKnight S. L., Russel D. W. RT Endothelial PAS domain protein 1 (EPAS1), a transcription factor selectively expressed in endothelial cells. RL Genes Dev. 11:72-82 (1997). RN [4]; RE0013592. RX PUBMED: 9079689. RA Hogenesch J. B., Chan W. K., Jackiw V. H., Brown R. C., Gu Y.-Z., Pray-Grant M., Perdew G. H., Bradfield C. A. RT Characterization of a subset of the basic-helix-loop-helix-PAS superfamily that interacts with components of the dioxin signaling pathway RL J. Biol. Chem. 272:8581-8593 (1997). RN [5]; RE0021482. RX PUBMED: 12097158. RA Tsuchiya T., Kominato Y., Ueda M. RT Human Hypoxic Signal Transduction through a Signature Motif in Hepatocyte Nuclear Factor 4 RL J. Biochem. 132:37-44 (2002). RN [6]; RE0022318. RX PUBMED: 11823643. RA Lando D., Peet D. J., Whelan D. A., Gorman J. J., Whitelaw M. L. RT Asparagine hydroxylation of the HIF transactivation domain a hypoxic switch. RL Science 295:858-861 (2002). RN [7]; RE0022327. RX PUBMED: 11595184. RA Epstein A. C., Gleadle J. M., McNeill L. A., Hewitson K. S., O'Rourke J., Mole D. R., Mukherji M., Metzen E., Wilson M. I., Dhanda A., Tian Y.-M., Masson N., Hamilton D. L., Jaakkola P., Barstead R., Hodgkin J., Maxwell P. H., Pugh C. W., Schofield C. J., Ratcliffe P. J. RT C. elegans EGL-9 and mammalian homologs define a family of dioxygenases that regulate HIF by prolyl hydroxylation. RL Cell 107:43-54 (2001). RN [8]; RE0022396. RX PUBMED: 10207038. RA Chan W. K., Yao G., Gu Y. Z., Bradfield C. A. RT Cross-talk between the aryl hydrocarbon receptor and hypoxia inducible factor signaling pathways. Demonstration of competition and compensation. RL J. Biol. Chem. 274:12115-12123 (1999). RN [9]; RE0022414. RX PUBMED: 9653127. RA Huang L. E., Gu J., Schau M., Bunn H. F. RT Regulation of hypoxia-inducible factor 1alpha is mediated by an O2-dependent degradation domain via the ubiquitin-proteasome pathway. RL Proc. Natl. Acad. Sci. USA 95:7987-7992 (1998). RN [10]; RE0022425. RX PUBMED: 11100117. RA Kung A. L., Wang S., Klco J. M., Kaelin W. G., Livingston D. M. RT Suppression of tumor growth through disruption of hypoxia-inducible transcription. RL Nat. Med. 6:1335-1340 (2000). RN [11]; RE0022461. RX PUBMED: 11382768. RA Fatyol K., Szalay A. A. RT The p14ARF tumor suppressor protein facilitates nucleolar sequestration of hypoxia-inducible factor-1alpha (HIF-1alpha ) and inhibits HIF-1-mediated transcription. RL J. Biol. Chem. 276:28421-28429 (2001). RN [12]; RE0034396. RX PUBMED: 12697324. RA Graven K. K., Bellur D., Klahn B. D., Lowrey S. L., Amberger E. RT HIF-2alpha regulates glyceraldehyde-3-phosphate dehydrogenase expression in endothelial cells. RL Biochim. Biophys. Acta 1626:10-18 (2003). RN [13]; RE0034409. RX PUBMED: 12939282. RA Kunz M., Moeller S., Koczan D., Lorenz P., Wenger R. H., Glocker M. O., Thiesen H. J., Gross G., Ibrahim S. M. RT Mechanisms of hypoxic gene regulation of angiogenesis factor Cyr61 in melanoma cells. RL J. Biol. Chem. 278:45651-60 (2003). RN [14]; RE0047822. RX PUBMED: 10903152. RA Hulkko S. M., Wakui H., Zilliacus J. RT The pro-apoptotic protein death-associated protein 3 (DAP3) interacts with the glucocorticoid receptor and affects the receptor function. RL Biochem. J. 349:885-893 (2000). RN [15]; RE0050474. RX PUBMED: 16543242. RA Kang H. J., Kim H. J., Rih J. K., Mattson T. L., Kim K. W., Cho C. H., Isaacs J. S., Bae I. RT BRCA1 plays a role in the hypoxic response by regulating HIF-1alpha stability and by modulating vascular endothelial growth factor expression. RL J. Biol. Chem. 281:13047-13056 (2006). RN [16]; RE0050681. RX PUBMED: 17374610. RA Martens L. K., Kirschner K. M., Warnecke C., Scholz H. RT Hypoxia-inducible factor-1 (HIF-1) is a transcriptional activator of the TrkB neurotrophin receptor gene. RL J. Biol. Chem. 282:14379-14388 (2007). RN [17]; RE0050771. RX PUBMED: 15466858. RA Obach M., Navarro-Sabate A., Caro J., Kong X., Duran J., Gomez M., Perales J. C., Ventura F., Rosa J. L., Bartrons R. RT 6-Phosphofructo-2-kinase (pfkfb3) gene promoter contains hypoxia-inducible factor-1 binding sites necessary for transactivation in response to hypoxia. RL J. Biol. Chem. 279:53562-53570 (2004). RN [18]; RE0050822. RX PUBMED: 15252039. RA Lofstedt T., Jogi A., Sigvardsson M., Gradin K., Poellinger L., Pahlman S., Axelson H. RT Induction of ID2 expression by hypoxia-inducible factor-1: a role in dedifferentiation of hypoxic neuroblastoma cells. RL J. Biol. Chem. 279:39223-39231 (2004). RN [19]; RE0050854. RX PUBMED: 10886548. RA El Awad B., Kreft B., Wolber E. M., Hellwig-Burgel T., Metzen E., Fandrey J., Jelkmann W. RT Hypoxia and interleukin-1beta stimulate vascular endothelial growth factor production in human proximal tubular cells. RL Kidney Int. 58:43-50 (2000). RN [20]; RE0051079. RX PUBMED: 12154035. RA Rapisarda A., Uranchimeg B., Scudiero D. A., Selby M., Sausville E. A., Shoemaker R. H., Melillo G. RT Identification of small molecule inhibitors of hypoxia-inducible factor 1 transcriptional activation pathway. RL Cancer Res. 62:4316-4324 (2002). RN [21]; RE0051087. RX PUBMED: 10607702. RA Kimura H., Weisz A., Kurashima Y., Hashimoto K., Ogura T., D'Acquisto F., Addeo R., Makuuchi M., Esumi H. RT Hypoxia response element of the human vascular endothelial growth factor gene mediates transcriptional regulation by nitric oxide: control of hypoxia-inducible factor-1 activity by nitric oxide. RL Blood 95:189-197 (2000). RN [22]; RE0051343. RX PUBMED: 16645044. RA Wang R., Zhang Y. W., Zhang X., Liu R., Zhang X., Hong S., Xia K., Xia J., Zhang Z., Xu H. RT Transcriptional regulation of APH-1A and increased gamma-secretase cleavage of APP and Notch by HIF-1 and hypoxia. RL FASEB J. 20:1275-1277 (2006). RN [23]; RE0051448. RX PUBMED: 17121991. RA Sun X., He G., Qing H., Zhou W., Dobie F., Cai F., Staufenbiel M., Huang L. E., Song W. RT Hypoxia facilitates Alzheimer's disease pathogenesis by up-regulating BACE1 gene expression. RL Proc. Natl. Acad. Sci. USA 103:18727-18732 (2006). RN [24]; RE0065237. RX PUBMED: 17308114. RA Spinella F., Rosano L., Di Castro V., Decandia S., Nicotra M. R., Natali P. G., Bagnato A. RT Endothelin-1 and endothelin-3 promote invasive behavior via hypoxia-inducible factor-1alpha in human melanoma cells. RL Cancer Res. 67:1725-1734 (2007). RN [25]; RE0065689. RX PUBMED: 18606657. RA Gerber S. A., Pober J. S. RT IFN-alpha induces transcription of hypoxia-inducible factor-1alpha to inhibit proliferation of human endothelial cells. RL J. Immunol. 181:1052-1062 (2008). RN [26]; RE0066549. RX PUBMED: 18345027. RA Nakamura H., Tanimoto K., Hiyama K., Yunokawa M., Kawamoto T., Kato Y., Yoshiga K., Poellinger L., Hiyama E., Nishiyama M. RT Human mismatch repair gene, MLH1, is transcriptionally repressed by the hypoxia-inducible transcription factors, DEC1 and DEC2. RL Oncogene 27:4200-4209 (2008). RN [27]; RE0066799. RX PUBMED: 20448047. RA Patel N., Kalra V. K. RT Placenta growth factor (PlGF)-induced early growth response 1 (Egr-1) regulates hypoxia inducible factor-1{alpha} (HIF-1{alpha}) in endothelial cells. RL J. Biol. Chem. 285:20570-20579 (2010). RN [28]; RE0067598. RX PUBMED: 18424433. RA Miyauchi Y., Kato M., Tokunaga F., Iwai K. RT The COP9/signalosome increases the efficiency of von Hippel-Lindau protein ubiquitin ligase-mediated hypoxia-inducible factor-alpha ubiquitination. RL J. Biol. Chem. 283:16622-16631 (2008). RN [29]; RE0068723. RX PUBMED: 16511565. RA Yoo Y. G., Kong G., Lee M. O. RT Metastasis-associated protein 1 enhances stability of hypoxia-inducible factor-1alpha protein by recruiting histone deacetylase 1. RL EMBO J. 25:1231-1241 (2006). RN [30]; RE0068729. RX PUBMED: 16376303. RA Kim S. H., Park J. A., Kim J. H., Lee J. W., Seo J. H., Jung B. K., Chun K. H., Jeong J. W., Bae M. K., Kim K. W. RT Characterization of ARD1 variants in mammalian cells. RL Biochem. Biophys. Res. Commun. 340:422-427 (2006). RN [31]; RE0068774. RX PUBMED: 15721254. RA Baek J. H., Mahon P. C., Oh J., Kelly B., Krishnamachary B., Pearson M., Chan D. A., Giaccia A. J., Semenza G. L. RT OS-9 interacts with hypoxia-inducible factor 1alpha and prolyl hydroxylases to promote oxygen-dependent degradation of HIF-1alpha. RL Mol. Cell 17:503-512 (2005). RN [32]; RE0068794. RX PUBMED: 18838541. RA Koh M. Y., Darnay B. G., Powis G. RT Hypoxia-associated factor, a novel E3-ubiquitin ligase, binds and ubiquitinates hypoxia-inducible factor 1alpha, leading to its oxygen-independent degradation. RL Mol. Cell. Biol. 28:7081-7095 (2008). RN [33]; RE0069561. RX PUBMED: 20699359. RA Kalousi A., Mylonis I., Politou A. S., Chachami G., Paraskeva E., Simos G. RT Casein kinase 1 regulates human hypoxia-inducible factor HIF-1. RL J. Cell Sci. 123:2976-2986 (2010). RN [34]; RE0070123. RX PUBMED: 19381167. RA Nicholas S. A., Sumbayev V. V. RT The involvement of hypoxia-inducible factor 1 alpha in Toll-like receptor 7/8-mediated inflammatory response. RL Cell Res. 19:973-983 (2009). RN [35]; RE0070131. RX PUBMED: 20696840. RA Culver C., Sundqvist A., Mudie S., Melvin A., Xirodimas D., Rocha S. RT Mechanism of hypoxia-induced NF-kappaB. RL Mol. Cell. Biol. 30:4901-4921 (2010). RN [36]; RE0070477. RX PUBMED: 21193393. RA Ryu J. H., Li S. H., Park H. S., Park J. W., Lee B., Chun Y. S. RT Hypoxia-inducible factor alpha subunit stabilization by NEDD8 conjugation is reactive oxygen species-dependent. RL J. Biol. Chem. 286:6963-6970 (2011). RN [37]; RE0071619. RX PUBMED: 21998407. RA Kryczek I., Zhao E., Liu Y., Wang Y., Vatan L., Szeliga W., Moyer J., Klimczak A., Lange A., Zou W. RT Human TH17 cells are long-lived effector memory cells. RL Sci. Transl. Med. 3:104ra100 (2011). RN [38]; RE0072999. RX PUBMED: 18781797. RA Meierhofer D., Wang X., Huang L., Kaiser P. RT Quantitative analysis of global ubiquitination in HeLa cells by mass spectrometry. RL J. Proteome Res. 7:4566-4576 (2008). RN [39]; RE0022426. RX PUBMED: 10544245. RA Minet E., Mottet D., Michel G., Roland I., Raes M., Remacle J., Michiels C. RT Hypoxia-induced activation of HIF-1: role of HIF-1alpha-Hsp90 interaction. RL FEBS Lett. 460:251-256 (1999). RN [40]; RE0022429. RX PUBMED: 12052835. RA Isaacs J. S., Jung Y.-J., Mimnaugh E. G., Martinez A., Cuttitta F., Neckers L. M. RT Hsp90 regulates a von Hippel Lindau-independent hypoxia-inducible factor-1 alpha-degradative pathway. RL J. Biol. Chem. 277:29936-29944 (2002). RN [41]; RE0035641. RX PUBMED: 15199161. RA Nishi H., Nakada T., Kyo S., Inoue M., Shay J. W., Isaka K. RT Hypoxia-inducible factor 1 mediates upregulation of telomerase (hTERT). RL Mol. Cell. Biol. 24:6076-6083 (2004). XX //