AC T08412
XX
ID T08412
XX
DT 18.01.2006 (created); kau.
DT 23.01.2014 (updated); yre.
CO Copyright (C), QIAGEN.
XX
FA beta-catenin
XX
SY beta-catenin; CATNB; CTNNB1.
XX
OS mouse, Mus musculus
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae
XX
GE G005040 Ctnnb1.
XX
SZ 781 AA; 85.5 kDa (cDNA) (calc.).
XX
SQ MATQADLMELDMAMEPDRKAAVSHWQQQSYLDSGIHSGATTTAPSLSGKGNPEEEDVDTS
SQ QVLYEWEQGFSQSFTQEQVADIDGQYAMTRAQRVRAAMFPETLDEGMQIPSTQFDAAHPT
SQ NVQRLAEPSQMLKHAVVNLINYQDDAELATRAIPELTKLLNDEDQVVVNKAAVMVHQLSK
SQ KEASRHAIMRSPQMVSAIVRTMQNTNDVETARCTAGTLHNLSHHREGLLAIFKSGGIPAL
SQ VKMLGSPVDSVLFYAITTLHNLLLHQEGAKMAVRLAGGLQKMVALLNKTNVKFLAITTDC
SQ LQILAYGNQESKLIILASGGPQALVNIMRTYTYEKLLWTTSRVLKVLSVCSSNKPAIVEA
SQ GGMQALGLHLTDPSQRLVQNCLWTLRNLSDAATKQEGMEGLLGTLVQLLGSDDINVVTCA
SQ AGILSNLTCNNYKNKMMVCQVGGIEALVRTVLRAGDREDITEPAICALRHLTSRHQEAEM
SQ AQNAVRLHYGLPVVVKLLHPPSHWPLIKATVGLIRNLALCPANHAPLREQGAIPRLVQLL
SQ VRAHQDTQRRTSMGGTQQQFVEGVRMEEIVEGCTGALHILARDVHNRIVIRGLNTIPLFV
SQ QLLYSPIENIQRVAAGVLCELAQDKEAAEAIEAEGATAPLTELLHSRNEGVATYAAAVLF
SQ RMSEDKPQDYKKRLSVELTSSLFRTEPMAWNETADLGLDIGAQGEALGYRQDDPSYRSFH
SQ SGGYGQDALGMDPMMEHEMGGHHPGADYPVDGLPDLGHAQDLMDGLPPGDSNQLAWFDTD
SQ L
XX
SC Swiss-Prot#Q02248
XX
FT 141 180 
SM00185; arm_5.
FT 146 182 
PF02985; HEAT repeat.
FT 151 191 
PS50176; ARM_REPEAT.
FT 181 223 
SM00185; arm_5.
FT 193 236 
PS50176; ARM_REPEAT.
FT 224 264 
PF00514; Armadillo/beta-catenin-like repeat.
FT 224 264 
SM00185; arm_5.
FT 235 277 
PS50176; ARM_REPEAT.
FT 265 306 
SM00185; arm_5.
FT 277 319 
PS50176; ARM_REPEAT.
FT 308 349 SM00185; arm_5.
FT 319 362 PS50176; ARM_REPEAT.
FT 329 624 PF00478; IMP dehydrogenase / GMP reductase domain.
FT 350 390 PF00514; Armadillo/beta-catenin-like repeat.
FT 350 390 SM00185; arm_5.
FT 391 429 PF00514; Armadillo/beta-catenin-like repeat.
FT 392 429 SM00185; arm_5.
FT 400 442 PS50176; ARM_REPEAT.
FT 430 473 SM00185; arm_5.
FT 431 473 PF00514; Armadillo/beta-catenin-like repeat.
FT 442 484 PS50176; ARM_REPEAT.
FT 478 519 SM00185; arm_5.
FT 489 532 PS50176; ARM_REPEAT.
FT 520 582 SM00185; arm_5.
FT 583 623 PF00514; Armadillo/beta-catenin-like repeat.
FT 583 623 SM00185; arm_5.
FT 594 636 PS50176; ARM_REPEAT.
FT 624 664 PF00514; Armadillo/beta-catenin-like repeat.
FT 624 664 SM00185; arm_5.
XX
IN T01610 HIF-1alpha; human, Homo sapiens.
IN T09467 SF-1; human, Homo sapiens.
XX
DR TRANSPATH: MO000057343.
DR EMBL: M90364;
DR UniProtKB: Q02248;
XX
RN [1]; RE0035749.
RX PUBMED: 15967802.
RA Chen J., Wu A., Sun H., Drakas R., Garofalo C., Cascio S., Surmacz E., Baserga R.
RT Functional significance of type 1 insulin-like growth factor-mediated nuclear translocation of the insulin receptor substrate-1 and beta-catenin.
RL J. Biol. Chem. 280:29912-29920 (2005).
RN [2]; RE0066454.
RX PUBMED: 18480165.
RA Zhang Y., Andl T., Yang S. H., Teta M., Liu F., Seykora J. T., Tobias J. W., Piccolo S., Schmidt-Ullrich R., Nagy A., Taketo M. M., Dlugosz A. A., Millar S. E.
RT Activation of beta-catenin signaling programs embryonic epidermis to hair follicle fate.
RL Development 135:2161-2172 (2008).
RN [3]; RE0071287.
RX PUBMED: 18093941.
RA Abe K., Takeichi M.
RT EPLIN mediates linkage of the cadherin catenin complex to F-actin and stabilizes the circumferential actin belt.
RL Proc. Natl. Acad. Sci. USA 105:13-19 (2008).
RN [4]; RE0071402.
RX PUBMED: 20086044.
RA Peng X., Cuff L. E., Lawton C. D., DeMali K. A.
RT Vinculin regulates cell-surface E-cadherin expression by binding to beta-catenin.
RL J. Cell Sci. 123:567-577 (2010).
RN [5]; RE0071696.
RX PUBMED: 17318191.
RA Coluccia A. M., Vacca A., Dunach M., Mologni L., Redaelli S., Bustos V. H., Benati D., Pinna L. A., Gambacorti-Passerini C.
RT Bcr-Abl stabilizes beta-catenin in chronic myeloid leukemia through its tyrosine phosphorylation.
RL EMBO J. 26:1456-1466 (2007).
RN [6]; RE0071993.
RX PUBMED: 21074722.
RA Gladden A. B., Hebert A. M., Schneeberger E. E., McClatchey A. I.
RT The NF2 tumor suppressor, Merlin, regulates epidermal development through the establishment of a junctional polarity complex.
RL Dev. Cell 19:727-739 (2010).
XX
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