AC T10835
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ID T10835
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DT 21.09.2007 (created); kma.
DT 30.07.2015 (updated); msr.
CO Copyright (C), QIAGEN.
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FA arnt
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SY Ah receptor nuclear translocator; Arnt; aryl hydrocarbon receptor nuclear translocator; HIF-1beta; hypoxia-inducible factor 1beta.
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OS human, Homo sapiens
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; primates
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GE G004677 ARNT; HGNC: Arnt.
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CL C0010; bHLH; 1.2.5.2.1.
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CP U251 cells both under normoxia (21% oxygen) and hypoxia (1% oxygen) [3].
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IN T04074 brca1; human, Homo sapiens.
IN T08994 HIF-1alpha-isoform1; human, Homo sapiens.
IN T01610 HIF-1alpha; human, Homo sapiens.
IN T10516 HIF-1alpha; Mammalia.
IN T10851 HIF2A; human, Homo sapiens.
IN T15683 HIF2A; Mammalia.
IN T19234 sim2s; human, Homo sapiens.
IN T10782 Smad6; Mammalia.
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MX M00235 V$AHRARNT_01.
MX M00237 V$AHRARNT_02.
MX M00976 V$AHRHIF_Q6.
MX M08868 V$ARNTLIKE_Q6.
MX M00236 V$ARNT_01.
MX M00539 V$ARNT_02.
MX M03812 V$ARNT_Q6.
MX M08800 V$ARNT_Q6_01.
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BS R66276.
BS R66957.
BS R65043.
BS R67474.
BS R67475.
BS R31480.
BS R69059.
BS R69060.
BS R69061.
BS R28138.
BS R03219.
BS R32046.
BS R22251.
BS R66279.
BS R67480.
BS R62003.
BS R62004.
BS R64712.
BS R64713.
BS R64716.
BS R64717.
BS R64719.
BS R64721.
BS R64728.
BS R31481.
BS R10227.
BS R28141.
BS R00270.
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DR TRANSPATH: MO000114191.
DR UniProtKB: P27540; ARNT_HUMAN.
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RN [1]; RE0045609.
RX PUBMED: 14701734.
RA Ooe N., Saito K., Mikami N., Nakatuka I., Kaneko H.
RT Identification of a novel basic helix-loop-helix-PAS factor, NXF, reveals a Sim2 competitive, positive regulatory role in dendritic-cytoskeleton modulator drebrin gene expression
RL Mol. Cell. Biol. 24:608-16 (2004).
RN [2]; RE0050884.
RX PUBMED: 16567799.
RA Kang H. J., Kim H. J., Kim S. K., Barouki R., Cho C. H., Khanna K. K., Rosen E. M., Bae I.
RT BRCA1 modulates xenobiotic stress-inducible gene expression by interacting with ARNT in human breast cancer cells.
RL J. Biol. Chem. 281:14654-14662 (2006).
RN [3]; RE0051079.
RX PUBMED: 12154035.
RA Rapisarda A., Uranchimeg B., Scudiero D. A., Selby M., Sausville E. A., Shoemaker R. H., Melillo G.
RT Identification of small molecule inhibitors of hypoxia-inducible factor 1 transcriptional activation pathway.
RL Cancer Res. 62:4316-4324 (2002).
RN [4]; RE0059446.
RX PUBMED: 14668441.
RA Erbel P. J., Card P. B., Karakuzu O., Bruick R. K., Gardner K. H.
RT Structural basis for PAS domain heterodimerization in the basic helix--loop--helix-PAS transcription factor hypoxia-inducible factor.
RL Proc. Natl. Acad. Sci. USA 100:15504-15509 (2003).
RN [5]; RE0068773.
RX PUBMED: 19129502.
RA Scheuermann T. H., Tomchick D. R., Machius M., Guo Y., Bruick R. K., Gardner K. H.
RT Artificial ligand binding within the HIF2alpha PAS-B domain of the HIF2 transcription factor.
RL Proc. Natl. Acad. Sci. USA 106:450-455 (2009).
RN [6]; RE0068909.
RX PUBMED: 19324882.
RA Partch C. L., Card P. B., Amezcua C. A., Gardner K. H.
RT Molecular basis of coiled coil coactivator recruitment by the aryl hydrocarbon receptor nuclear translocator (ARNT).
RL J. Biol. Chem. 284:15184-15192 (2009).
RN [7]; RE0069561.
RX PUBMED: 20699359.
RA Kalousi A., Mylonis I., Politou A. S., Chachami G., Paraskeva E., Simos G.
RT Casein kinase 1 regulates human hypoxia-inducible factor HIF-1.
RL J. Cell Sci. 123:2976-2986 (2010).
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