AC T10851
XX
ID T10851
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DT 25.09.2007 (created); kma.
DT 30.09.2015 (updated); hna.
CO Copyright (C), QIAGEN.
XX
FA HIF2A
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SY endothelial PAS-1; HIF-2alpha; hypoxia inducible transcription factor 2alpha; member of PAS superfamily 2; MOP2.
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OS human, Homo sapiens
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; primates
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GE G004008 EPAS1; HGNC: EPAS1.
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CL C0010; bHLH.
XX
SZ 870 AA; 96.4 kDa (cDNA) (calc.).
XX
SQ MTADKEKKRSSSERRKEKSRDAARCRRSKETEVFYELAHELPLPHSVSSHLDKASIMRLA
SQ ISFLRTHKLLSSVCSENESEAEADQQMDNLYLKALEGFIAVVTQDGDMIFLSENISKFMG
SQ LTQVELTGHSIFDFTHPCDHEEIRENLSLKNGSGFGKKSKDMSTERDFFMRMKCTVTNRG
SQ RTVNLKSATWKVLHCTGQVKVYNNCPPHNSLCGYKEPLLSCLIIMCEPIQHPSHMDIPLD
SQ SKTFLSRHSMDMKFTYCDDRITELIGYHPEELLGRSAYEFYHALDSENMTKSHQNLCTKG
SQ QVVSGQYRMLAKHGGYVWLETQGTVIYNPRNLQPQCIMCVNYVLSEIEKNDVVFSMDQTE
SQ SLFKPHLMAMNSIFDSSGKGAVSEKSNFLFTKLKEEPEELAQLAPTPGDAIISLDFGNQN
SQ FEESSAYGKAILPPSQPWATELRSHSTQSEAGSLPAFTVPQAAAPGSTTPSATSSSSSCS
SQ TPNSPEDYYTSLDNDLKIEVIEKLFAMDTEAKDQCSTQTDFNELDLETLAPYIPMDGEGF
SQ QLSPICPEERLLAENPQSTPQHCFSAMTNIFQPLAPVAPHSPFLLDKFQQQLESKKTEPE
SQ RRPMSSIFFDAGSKASLPPCCGQASTPLSSMGGRSNTQWPPDPPLHFGPTKWAVGDQRTE
SQ FLGAAPLGPPVSPPHVSTFKTRSAKGFGARGPNVLSPAMVALSNKLKLKRQLEYEKQAFQ
SQ DPSGGDPPGGSTSHLMWKRMKNLRGGSCPLMPDKPLSANVPNDKLTQNSMRGLGHPLRHL
SQ PLPQPPSAISPGENSKSRFPPQCYATQYQDYSLSSAHKVSGMASRLLGPSFESYLLPELT
SQ RYDREVKVPVLGSSTLLQGGDLLRALDQAT
XX
SC Swiss-Prot#Q99814
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FT 13 68 
PS50888; HLH.
FT 15 68 
PF00010; Helix-loop-helix DNA-binding domain.
FT 20 75 
SM00353; finulus.
FT 86 152 
SM00091; pas_2.
FT 92 147 
PS50112; PAS.
FT 102 454 
PF00478; IMP dehydrogenase / GMP reductase domain.
FT 232 298 
SM00091; pas_2.
FT 249 300 
PS50112; PAS.
FT 304 347 
SM00086; pac_2.
FT 486 639 
activation domain [6].
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IN T10835 arnt; human, Homo sapiens.
IN T08499 CBP; mouse, Mus musculus.
IN T11136 DEC2; mouse, Mus musculus.
IN T08328 USF2; Mammalia.
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MX M01249 V$HIF2A_01.
MX M07356 V$HIF2A_Q6.
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BS R24274.
BS R32046.
BS R60749.
BS R60752.
BS R60754.
BS R13214.
BS R10227.
BS R37848.
XX
DR TRANSPATH: MO000114315.
DR EMBL: U51626;
DR EMBL: U81984;
DR UniProtKB: Q99814;
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RN [1]; RE0013520.
RX PUBMED: 9000051.
RA Tian H., McKnight S. L., Russel D. W.
RT Endothelial PAS domain protein 1 (EPAS1), a transcription factor selectively expressed in endothelial cells.
RL Genes Dev. 11:72-82 (1997).
RN [2]; RE0013592.
RX PUBMED: 9079689.
RA Hogenesch J. B., Chan W. K., Jackiw V. H., Brown R. C., Gu Y.-Z., Pray-Grant M., Perdew G. H., Bradfield C. A.
RT Characterization of a subset of the basic-helix-loop-helix-PAS superfamily that interacts with components of the dioxin signaling pathway
RL J. Biol. Chem. 272:8581-8593 (1997).
RN [3]; RE0059446.
RX PUBMED: 14668441.
RA Erbel P. J., Card P. B., Karakuzu O., Bruick R. K., Gardner K. H.
RT Structural basis for PAS domain heterodimerization in the basic helix--loop--helix-PAS transcription factor hypoxia-inducible factor.
RL Proc. Natl. Acad. Sci. USA 100:15504-15509 (2003).
RN [4]; RE0068773.
RX PUBMED: 19129502.
RA Scheuermann T. H., Tomchick D. R., Machius M., Guo Y., Bruick R. K., Gardner K. H.
RT Artificial ligand binding within the HIF2alpha PAS-B domain of the HIF2 transcription factor.
RL Proc. Natl. Acad. Sci. USA 106:450-455 (2009).
RN [5]; RE0068909.
RX PUBMED: 19324882.
RA Partch C. L., Card P. B., Amezcua C. A., Gardner K. H.
RT Molecular basis of coiled coil coactivator recruitment by the aryl hydrocarbon receptor nuclear translocator (ARNT).
RL J. Biol. Chem. 284:15184-15192 (2009).
RN [6]; RE0052421.
RX PUBMED: 10531360.
RA Maemura K., Hsieh C. M., Jain M. K., Fukumoto S., Layne M. D., Liu Y., Kourembanas S., Yet S. F., Perrella M. A., Lee M. E.
RT Generation of a dominant-negative mutant of endothelial PAS domain protein 1 by deletion of a potent C-terminal transactivation domain.
RL J. Biol. Chem. 274:31565-31570 (1999).
XX
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