AC T08499
XX
ID T08499
XX
DT 30.01.2006 (created); rad.
DT 27.06.2014 (updated); yre.
CO Copyright (C), QIAGEN.
XX
FA CBP
XX
SY CBP; CREB-binding protein; CREBBP.
XX
OS mouse, Mus musculus
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae
XX
GE G005950 Crebbp.
XX
SZ 2441 AA; 265.5 kDa (cDNA) (calc.).
XX
SQ MAENLLDGPPNPKRAKLSSPGFSANDNTDFGSLFDLENDLPDELIPNGELSLLNSGNLVP
SQ DAASKHKQLSELLRGGSGSSINPGIGNVSASSPVQQGLGGQAQGQPNSTNMASLGAMGKS
SQ PLNQGDSSTPNLPKQAASTSGPTPPASQALNPQAQKQVGLVTSSPATSQTGPGICMNANF
SQ NQTHPGLLNSNSGHSLMNQAQQGQAQVMNGSLGAAGRGRGAGMPYPAPAMQGATSSVLAE
SQ TLTQVSPQMAGHAGLNTAQAGGMTKMGMTGTTSPFGQPFSQTGGQQMGATGVNPQLASKQ
SQ SMVNSLPAFPTDIKNTSVTTVPNMSQLQTSVGIVPTQAIATGPTADPEKRKLIQQQLVLL
SQ LHAHKCQRREQANGEVRACSLPHCRTMKNVLNHMTHCQAGKACQVAHCASSRQIISHWKN
SQ CTRHDCPVCLPLKNASDKRNQQTILGSPASGIQNTIGSVGAGQQNATSLSNPNPIDPSSM
SQ QRAYAALGLPYMNQPQTQLQPQVPGQQPAQPPAHQQMRTLNALGNNPMSIPAGGITTDQQ
SQ PPNLISESALPTSLGATNPLMNDGSNSGNIGSLSTIPTAAPPSSTGVRKGWHEHVTQDLR
SQ SHLVHKLVQAIFPTPDPAALKDRRMENLVAYAKKVEGDMYESANSRDEYYHLLAEKIYKI
SQ QKELEEKRRSRLHKQGILGNQPALPASGAQPPVIPPAQSVRPPNGPLPLPVNRMQVSQGM
SQ NSFNPMSLGNVQLPQAPMGPRAASPMNHSVQMNSMASVPGMAISPSRMPQPPNMMGTHAN
SQ NIMAQAPTQNQFLPQNQFPSSSGAMSVNSVGMGQPAAQAGVSQGQVPGAALPNPLNMLAP
SQ QASQLPCPPVTQSPLHPTPPPASTAAGMPSLQHPTAPGMTPPQPAAPTQPSTPVSSGQTP
SQ TPTPGSVPSAAQTQSTPTVQAAAQAQVTPQPQTPVQPPSVATPQSSQQQPTPVHTQPPGT
SQ PLSQAAASIDNRVPTPSSVTSAETSSQQPGPDVPMLEMKTEVQTDDAEPEPTESKGEPRS
SQ EMMEEDLQGSSQVKEETDTTEQKSEPMEVEEKKPEVKVEAKEEEENSSNDTASQSTSPSQ
SQ PRKKIFKPEELRQALMPTLEALYRQDPESLPFRQPVDPQLLGIPDYFDIVKNPMDLSTIK
SQ RKLDTGQYQEPWQYVDDVWLMFNNAWLYNRKTSRVYKFCSKLAEVFEQEIDPVMQSLGYC
SQ CGRKYEFSPQTLCCYGKQLCTIPRDAAYYSYQNRYHFCEKCFTEIQGENVTLGDDPSQPQ
SQ TTISKDQFEKKKNDTLDPEPFVDCKECGRKMHQICVLHYDIIWPSGFVCDNCLKKTGRPR
SQ KENKFSAKRLQTTRLGNHLEDRVNKFLRRQNHPEAGEVFVRVVASSDKTVEVKPGMKSRF
SQ VDSGEMSESFPYRTKALFAFEEIDGVDVCFFGMHVQNTALIAPHQIQGRVYISYLDSIHF
SQ FRPRCLRTAVYHEILIGYLEYVKKLGYVTGHIWACPPSEGDDYIFHCHPPDQKIPKPKRL
SQ QEWYKKMLDKAFAERIINDYKDIFKQANEDRLTSAKELPYFEGDFWPNVLEESIKELEQE
SQ EEERKKEESTAASETPEGSQGDSKNAKKKNNKKTNKNKSSISRANKKKPSMPNVSNDLSQ
SQ KLYATMEKHKEVFFVIHLHAGPVISTQPPIVDPDPLLSCDLMDGRDAFLTLARDKHWEFS
SQ SLRRSKWSTLCMLVELHTQGQDRFVYTCNECKHHVETRWHCTVCEDYDLCINCYNTKSHT
SQ HKMVKWGLGLDDEGSSQGEPQSKSPQESRRLSIQRCIQSLVHACQCRNANCSLPSCQKMK
SQ RVVQHTKGCKRKTNGGCPVCKQLIALCCYHAKHCQENKCPVPFCLNIKHKLRQQQIQHRL
SQ QQAQLMRRRMATMNTRNVPQQSLPSPTSAPPGTPTQQPSTPQTPQPPAQPQPSPVNMSPA
SQ GFPNVARTQPPTIVSAGKPTNQVPAPPPPAQPPPAAVEAARQIEREAQQQQHLYRANINN
SQ GMPPGRAGMGTPGSQMTPVGLNVPRPNQVSGPVMSSMPPGQWQQAPIPQQQPMPGMPRPV
SQ MSMQAQAAVAGPRMPNVQPPRSISPSALQDLLRTLKSPSSPQQQQQVLNILKSNPQLMAA
SQ FIKQRTAKYVANQPGMQPQPGLQSQPGMQPQPGMHQQPSLQNLNAMQAGVPRPGVPPPQP
SQ AMGGLNPQGQALNIMNPGHNPNMTNMNPQYREMVRRQLLQHQQQQQQQQQQQQQQQNSAS
SQ LAGGMAGHSQFQQPQGPGGYAPAMQQQRMQQHLPIQGSSMGQMAAPMGQLGQMGQPGLGA
SQ DSTPNIQQALQQRILQQQQMKQQIGSPGQPNPMSPQQHMLSGQPQASHLPGQQIATSLSN
SQ QVRSPAPVQSPRPQSQPPHSSPSPRIQPQPSPHHVSPQTGSPHPGLAVTMASSMDQGHLG
SQ NPEQSAMLPQLNTPNRSALSSELSLVGDTTGDTLEKFVEGL
XX
SC Swiss-Prot#P45481
XX
FT 1 777 
binding of RelA [16].
FT 194 1577 
PF00478; IMP dehydrogenase / GMP reductase domain.
FT 227 410 
SRCAP T04151 interaction domain [20].
FT 346 432 
PS50134; ZF_TAZ.
FT 347 431 
PF02135; TAZ zinc finger.
FT 347 432 
SM00551; ZnF_TAZ.
FT 461 661 
binding to c-Jun T00131 [17].
FT 461 661 
binding to c-Myb T00138 [22].
FT 461 661 
binding to CREB T00163 [21].
FT 586 665 
PS50952; KIX.
FT 586 666 PF02172; KIX domain.
FT 1085 1195 SM00297; bromo_6.
FT 1091 1181 PF00439; Bromodomain.
FT 1104 1176 PS50014; BROMODOMAIN_2.
FT 1182 1242 PF06001; Domain of Unknown Function (DUF902).
FT 1317 1554 PF06010; Domain of Unknown Function (DUF906).
FT 1621 1877 binding to c-Fos T00122 [18].
FT 1621 1877 binding to E1A, E2F-1 [23].
FT 1679 1874 binding to ARIX T03960 and Pmx2b T03961 [19].
FT 1702 1743 PF00569; Zinc finger, ZZ type.
FT 1702 1743 SM00291; zz_5.
FT 1702 1745 PS50135; ZF_ZZ_2.
FT 1758 2441 binding to STAT1 [16].
FT 1765 1844 PF02135; TAZ zinc finger.
FT 1766 1847 PS50134; ZF_TAZ.
FT 1767 1845 SM00551; ZnF_TAZ.
XX
IN T14513 beta-catenin; Mammalia.
IN T23329 BMAL1; Mammalia.
IN T08420 c-Ets-1; mouse, Mus musculus.
IN T01397 c-Ets-2; mouse, Mus musculus.
IN T00100 CDP; human, Homo sapiens.
IN T25761 CNOT3; mouse, Mus musculus.
IN T08452 CREB1; rat, Rattus norvegicus.
IN T13855 E2A; Mammalia.
IN T08445 Elk1-isoform1; human, Homo sapiens.
IN T08300 ER-alpha-L; human, Homo sapiens.
IN T17427 ER-beta; mouse, Mus musculus.
IN T09602 ER; Mammalia.
IN T10472 Fli-1; Mammalia.
IN T10059 GCMa; human, Homo sapiens.
IN T10851 HIF2A; human, Homo sapiens.
IN T00719 NR1B1-isoform1; human, Homo sapiens.
IN T00325 Pit-1B; human, Homo sapiens.
IN T00702 PU.1; mouse, Mus musculus.
IN T14321 RelA-p65; Mammalia.
IN T01333 RXR-gamma; mouse, Mus musculus.
IN T08551 SF-1; mouse, Mus musculus.
IN T30703 SIRT1; Mammalia.
IN T09269 Spi-B-isoform1; human, Homo sapiens.
IN T01342 T3R-alpha1; rat, Rattus norvegicus.
IN T01350 T3R-beta2; rat, Rattus norvegicus.
IN T19373 ZNF151; mouse, Mus musculus.
XX
DR TRANSPATH: MO000059021.
DR EMBL: S66385;
DR UniProtKB: P45481;
XX
RN [1]; RE0004734.
RX PUBMED: 8616895.
RA Kamei Y., Xu L., Heinzel T., Torchia J., Kurokawa R., Gloss B., Lin S.-C., Heyman R. A., Rose D. W., Glass C. K., Rosenfeld M. G.
RT A CBP integrator complex mediates transcriptional activation and AP-1 inhibition by nuclear receptors
RL Cell 85:403-414 (1996).
RN [2]; RE0023723.
RX PUBMED: 11864910.
RA Yamamoto H., Kihara-Negishi F., Yamada T., Suzuki M., Nakano T., Oikawa T.
RT Interaction between the hematopoietic Ets transcription factor Spi-B and the coactivator CREB-binding protein associated with negative cross-talk with c-Myb.
RL Cell Growth Differ. 13:69-75 (2002).
RN [3]; RE0028344.
RX PUBMED: 11083868.
RA Nissen L. J., Gelly J. C., Hipskind R. A.
RT Induction-independent recruitment of CREB-binding protein to the c-fos serum response element through interactions between the bromodomain and Elk-1.
RL J. Biol. Chem. 276:5213-21 (2001).
RN [4]; RE0042400.
RX PUBMED: 10852958.
RA Li S., Aufiero B., Schiltz R. L., Walsh M. J.
RT Regulation of the homeodomain CCAAT displacement/cut protein function by histone acetyltransferases p300/CREB-binding protein (CBP)-associated factor and CBP
RL Proc. Natl. Acad. Sci. USA 97:7166-71 (2000).
RN [5]; RE0047427.
RX PUBMED: 9556555.
RA Na S. Y., Lee S. K., Han S. J., Choi H. S., Im S. Y., Lee J. W.
RT Steroid receptor coactivator-1 interacts with the p50 subunit and coactivates nuclear factor kappaB-mediated transactivations.
RL J. Biol. Chem. 273:10831-10834 (1998).
RN [6]; RE0047584.
RX PUBMED: 10823961.
RA Ko L., Cardona G. R., Chin W. W.
RT Thyroid hormone receptor-binding protein, an LXXLL motif-containing protein, functions as a general coactivator.
RL Proc. Natl. Acad. Sci. USA 97:6212-6217 (2000).
RN [7]; RE0048566.
RX PUBMED: 15572696.
RA Foulds C. E., Nelson M. L., Blaszczak A. G., Graves B. J.
RT Ras/mitogen-activated protein kinase signaling activates Ets-1 and Ets-2 by CBP/p300 recruitment.
RL Mol. Cell. Biol. 24:10954-10964 (2004).
RN [8]; RE0048766.
RX PUBMED: 16287980.
RA Kuo H. Y., Chang C. C., Jeng J. C., Hu H. M., Lin D. Y., Maul G. G., Kwok R. P., Shih H. M.
RT SUMO modification negatively modulates the transcriptional activity of CREB-binding protein via the recruitment of Daxx.
RL Proc. Natl. Acad. Sci. USA 102:16973-16978 (2005).
RN [9]; RE0048894.
RX PUBMED: 15752756.
RA Yin X., Warner D. R., Roberts E. A., Pisano M. M., Greene R. M.
RT Identification of novel CBP interacting proteins in embryonic orofacial tissue.
RL Biochem. Biophys. Res. Commun. 329:1010-1017 (2005).
RN [10]; RE0048970.
RX PUBMED: 16645037.
RA Tian H., Mahajan M. A., Wong C. T., Habeos I., Samuels H. H.
RT The N-Terminal A/B domain of the thyroid hormone receptor-beta2 isoform influences ligand-dependent recruitment of coactivators to the ligand-binding domain.
RL Mol. Endocrinol. 20:2036-2051 (2006).
RN [11]; RE0049106.
RX PUBMED: 16166624.
RA Chang C. W., Chuang H. C., Yu C., Yao T. P., Chen H.
RT Stimulation of GCMa transcriptional activity by cyclic AMP/protein kinase A signaling is attributed to CBP-mediated acetylation of GCMa.
RL Mol. Cell. Biol. 25:8401-8414 (2005).
RN [12]; RE0049157.
RX PUBMED: 15273724.
RA Ramakrishnan R., Fujimura Y., Zou J. P., Liu F., Lee L., Rao V. N., Reddy E. S.
RT Role of protein-protein interactions in the antiapoptotic function of EWS-Fli-1.
RL Oncogene 23:7087-7094 (2004).
RN [13]; RE0052367.
RX PUBMED: 17166829.
RA Sanchez M., Sauve K., Picard N., Tremblay A.
RT The hormonal response of estrogen receptor beta is decreased by the phosphatidylinositol 3-kinase/Akt pathway via a phosphorylation-dependent release of CREB-binding protein.
RL J. Biol. Chem. 282:4830-4840 (2007).
RN [14]; RE0053034.
RX PUBMED: 16059639.
RA Liu Y., Shen Q., Malloy P. J., Soliman E., Peng X., Kim S., Pike J. W., Feldman D., Christakos S.
RT Enhanced coactivator binding and transcriptional activation of mutant vitamin D receptors from patients with hereditary 1,25-dihydroxyvitamin D-resistant rickets by phosphorylation and vitamin D analogs.
RL J. Bone Miner. Res. 20:1680-1691 (2005).
RN [15]; RE0056145.
RX PUBMED: 16263824.
RA Cohen R. N., Brue T., Naik K., Houlihan C. A., Wondisford F. E., Radovick S.
RT The role of CBP/p300 interactions and Pit-1 dimerization in the pathophysiological mechanism of combined pituitary hormone deficiency.
RL J. Clin. Endocrinol. Metab. 91:239-247 (2006).
RN [16]; RE0024015.
RX PUBMED: 12403783.
RA Hiroi M., Ohmori Y.
RT The transcriptional coactivator CREB-binding protein cooperates with STAT1 and NF-kappa B for synergistic transcriptional activation of the CXC ligand 9/monokine induced by interferon-gamma gene.
RL J. Biol. Chem. 278:651-660 (2003).
RN [17]; RE0005633.
RX PUBMED: 8545107.
RA Bannister A. J., Oehler T., Wilhelm D., Angel P., Kouzarides T.
RT Stimulation of c-Jun activity by CBP: c-Jun residues Ser63/73 are required for CBP induced stimulation in vivo and CBP binding in vitro
RL Oncogene 11:2509-2514 (1995).
RN [18]; RE0005630.
RX PUBMED: 7588605.
RA Bannister A. J., Kouzarides T.
RT CBP-induced stimulation of c-Fos activity is abrogated by E1A
RL EMBO J. 14:4758-4762 (1995).
RN [19]; RE0015252.
RX PUBMED: 10644760.
RA Swanson D. J., Adachi M., Lewis E. J.
RT The homeodomain protein Arix promotes protein kinase A-dependent activation of the dopamine beta-hydroxylase promoter through multiple elements and interaction with the coactivator cAMP-response element-binding protein-binding protein
RL J. Biol. Chem. 275:2911-2923 (2000).
RN [20]; RE0015534.
RX PUBMED: 10347196.
RA Johnston H., Kneer J., Chackalaparampil I., Yaciuk P., Chrivia J.
RT Identification of a novel SNF2/SWI2 protein family member, SRCAP, which interacts with CREB-binding protein
RL J. Biol. Chem. 274:16370-16376 (1999).
RN [21]; RE0001914.
RX PUBMED: 8413673.
RA Chrivia J. C., Kwok R. P. S., Lamb N., Hagiwara M., Montminy M. R., Goodman R. H.
RT Phosphorylated CREB binds specifically to the nuclear protein CBP
RL Nature 365:855-859 (1993).
RN [22]; RE0005628.
RX PUBMED: 8598284.
RA Dai P., Akimaru H., Tanaka Y., Hou D.-X., Yasukawa T., Kanei-Ishii C., Takahashi T., Ishii S.
RT CBP as a transcriptional coactivator of c-Myb
RL Genes Dev. 10:528-540 (1996).
RN [23]; RE0005629.
RX PUBMED: 8932363.
RA Trouche D., Cook A., Kouzarides T.
RT The CBP co-activator stimulates E2F1/DP1 activity
RL Nucleic Acids Res. 24:4139-4145 (1996).
XX
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