AC T00325
XX
ID T00325
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DT 15.10.1992 (created); ewi.
DT 10.10.2011 (updated); jig.
CO Copyright (C), QIAGEN.
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FA Pit-1B
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SY GHF-1; growth hormone factor 1; Pit-1; Pit-1b; Pituitary-specific factor 1; pituitary-specific positive transcription factor 1; POU1F1.
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OS human, Homo sapiens
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; primates
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GE G003928 POU1F1; HGNC: POU1F1.
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CL C0007; POU; 3.1.10.1.1.2.
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SZ 291 AA; 32.9 kDa (cDNA) (calc.).
XX
SQ MSCQAFTSADTFIPLNSDASATLPLIMHHSAAECLPVSNHATNVMSTATGLHYSVPSCHY
SQ GNQPSTYGVMAGSLTPCLYKFPDHTLSHGFPPIHQPLLAEDPTAADFKQELRRKSKLVEE
SQ PIDMDSPEIRELEKFANEFKVRRIKLGYTQTNVGEALAAVHGSEFSQTTICRFENLQLSF
SQ KNACKLKAILSKWLEEAEQVGALYNEKVGANERKRKRRTTISIAAKDALERHFGEQNKPS
SQ SQEIMRMAEELNLEKEVVRVWFCNRRQREKRVKTSLNQSLFSISKEHLECR
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SC Swiss-Prot#P28069-1
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FT 124 198 
PF00157; Pou domain - N-terminal to homeobox domain.
FT 124 198 
SM00352; pou.
FT 212 272 
PS50071; HOMEOBOX_2.
FT 212 274 
PS50550; POU_HOMEODOMAIN.
FT 214 276 
SM00389; HOX_1.
FT 215 271 
PF00046; Homeobox domain.
XX
CP pituitary [6].
CN decidua, placenta [6].
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FF activator, stimulating cells proliferation of somatotrophs, lactotrophs, and thyrotrophs [6];
FF naturally occurring A158P mutant within helix 1 of POU2 has lost gene activation capability, but still stimulates proliferation causing hypopituitarism in homozygous individuals [6];
FF R271W mutation (C-terminal border of POUh) leads to a DNA-binding dominant inhibitor affecting heterozygous individuals causing GH, Prl and TSH deficiency and, thus, mental and physical retardation (CPHD, Combined Pituitary Hormone Deficiency) [6] [7] [9];
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IN T00112 c-Ets-1A; human, Homo sapiens.
IN T08499 CBP; mouse, Mus musculus.
IN T00325 Pit-1B; human, Homo sapiens.
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MX M01465 V$PIT1_01.
MX M00802 V$PIT1_Q6.
MX M03559 V$PIT1_Q6_01.
MX M00744 V$POU1F1_Q6.
XX
BS R02160.
BS R00611.
BS R00612.
BS R03100.
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DR TRANSPATH: MO000024854.
DR TRANSCOMPEL: C00138.
DR PATHODB: MT000002.
DR PATHODB: MT000003.
DR PATHODB: MT000004.
DR PATHODB: MT000005.
DR PATHODB: MT000006.
DR PATHODB: MT000007.
DR PATHODB: MT000008.
DR PATHODB: MT000009.
DR EMBL: D10216;
DR EMBL: X62429;
DR UniProtKB: P28069-1;
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RN [1]; RE0000072.
RX PUBMED: 3594572.
RA Bodner M., Karin M.
RT A Pituitary-Specific Trans-Acting Factor Can Stimulate Transcription from the Growth Hormone Promoter in Extracts of Nonexpressing Cells
RL Cell 50:267-275 (1987).
RN [2]; RE0000073.
RX PUBMED: 2902927.
RA Bodner M., Castrillo J.-L., Theill L. E., Deerinck T., Ellisman M., Karin M.
RT The Pituitary-Specific Transcription Factor GHF-1 Is a Homeobox-Containing Protein
RL Cell 55:505-518 (1988).
RN [3]; RE0000347.
RX PUBMED: 3595566.
RA Lefevre C., Imagawa M., Dana S., Grindlay J., Bodner M., Karin M.
RT Tissue-specific expression of the human growth hormone gene is conferred in part by the binding of a specific trans-acting factor
RL EMBO J. 6:971-981 (1987).
RN [4]; RE0001249.
RX PUBMED: 2903436.
RA Hyman S. E., Comb M., Lin Y.-S., Pearlberg J., Green M. R., Goodman H. M.
RT A Common trans-Acting Factor Is Involved in Transcriptional Regulation of Neurotransmitter Genes by Cyclic AMP
RL Mol. Cell. Biol. 8:4225-4233 (1988).
RN [5]; RE0002021.
RX PUBMED: 2717408.
RA Sharp Z. D., Helsel S., Cao Z., Barron E. A., Sanchez Y.
RT DNA recognition element required for PUF-I mediated cell-type specific transcription of the rat prolactin gene
RL Nucleic Acids Res. 17:2705-2722 (1989).
RN [6]; RE0004433.
RX PUBMED: 1509263.
RA Pfaeffle R. W., DiMattia G. E., Parks J. S., Brown M. R., Wit J. M., Jansen M., van der Nat H., van den Brande J. L., Rosenfeld M. G., Ingraham H. A.
RT Mutation of the POU-specific domain of Pit-1 and hypopituitarism without pituitary hypoplasia
RL Science 257:1118-1121 (1992).
RN [7]; RE0004434.
RX PUBMED: 1509262.
RA Radovick S., Nations M., Du Y., Berg L. A., Weintraub B. D., Wondisford F. E.
RT A mutation in the POU-homeodomain of Pit-1 responsible for Combined Pituitary Hormone Deficiency
RL Science 257:1115-1118 (1992).
RN [8]; RE0004436.
RX PUBMED: 8346040.
RA Pernasetti F. M., Wera S., Belayew A., Martial J. A.
RT Cloning of a human GHF-1/PIT-1 cDNA variant
RL Nucleic Acids Res. 21:3584-3584 (1993).
RN [9]; RE0004444.
RX PUBMED: 1472057.
RA Ohta K., Nobukuni Y., Mitsubuchi H., Fujimoto S., Matsuo N., Inagaki H., Endo F., Matsuda I.
RT Mutations in the Pit-1 gene in children with combined pituitary hormone deficiency
RL Biochem. Biophys. Res. Commun. 189:851-855 (1992).
RN [10]; RE0047927.
RX PUBMED: 12242337.
RA Augustijn K. D., Duval D. L., Wechselberger R., Kaptein R., Gutierrez-Hartmann A., van der Vliet P. C.
RT Structural characterization of the PIT-1/ETS-1 interaction: PIT-1 phosphorylation regulates PIT-1/ETS-1 binding.
RL Proc. Natl. Acad. Sci. USA 99:12657-12662 (2002).
RN [11]; RE0056145.
RX PUBMED: 16263824.
RA Cohen R. N., Brue T., Naik K., Houlihan C. A., Wondisford F. E., Radovick S.
RT The role of CBP/p300 interactions and Pit-1 dimerization in the pathophysiological mechanism of combined pituitary hormone deficiency.
RL J. Clin. Endocrinol. Metab. 91:239-247 (2006).
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