AC T00112
XX
ID T00112
XX
DT 26.10.1992 (created); ewi.
DT 29.07.2014 (updated); sla.
CO Copyright (C), QIAGEN.
XX
FA c-Ets-1A
XX
SY c-Ets-1; c-Ets-1 54; c-Ets-1A; Ets1; p54; p54c-Ets-1.
XX
OS human, Homo sapiens
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; primates
XX
GE G000217 ETS1; HGNC: Ets1.
XX
CL C0016; ETS; 3.5.2.1.1.1.
XX
SZ 441 AA; 50.4 kDa (cDNA) (calc.), 60 kDa, 55 kDa
XX
SQ MKAAVDLKPTLTIIKTEKVDLELFPSPDMECADVPLLTPSSKEMMSQALKATFSGFTKEQ
SQ QRLGIPKDPRQWTETHVRDWVMWAVNEFSLKGVDFQKFCMNGAALCALGKDCFLELAPDF
SQ VGDILWEHLEILQKEDVKPYQVNGVNPAYPESRYTSDYFISYGIEHAQCVPPSEFSEPSF
SQ ITESYQTLHPISSEELLSLKYENDYPSVILRDPLQTDTLQNDYFAIKQEVVTPDNMCMGR
SQ TSRGKLGGQDSFESIESYDSCDRLTQSWSSQSSFNSLQRVPSYDSFDSEDYPAALPNHKP
SQ KGTFKDYVRDRADLNKDKPVIPAAALAGYTGSGPIQLWQFLLELLTDKSCQSFISWTGDG
SQ WEFKLSDPDEVARRWGKRKNKPKMNYEKLSRGLRYYYDKNIIHKTAGKRYVYRFVCDLQS
SQ LLGYTPEELHAMLDVKPDADE
XX
SC Swiss-Prot#P14921-1
XX
FT 53 136 
PF02198; Sterile alpha motif (SAM)/Pointed domain.
FT 53 136 
SM00251; SAM2_3.
FT 68 141 
POINTED domain [16].
FT 334 414 
ETS domain [16].
FT 334 417 
PF00178; Ets-domain.
FT 334 419 
SM00413; etsneu2.
FT 335 415 
PS50061; ETS_DOMAIN_3.
FT 337 405 
PS50140; HSF_ETS.
XX
SF alternative splice variants: c-Ets-1ADeltaVII (lacking sequences encoded by exon VII) T01400, c-Ets-1ADelta IV (lacking exon IV) or variant that lacks both regions [10] [11];
SF phosphorylation (Ca-dependent);
SF isoform of 48 kDa may be due to SH-modification [4];
XX
CP T-cells (predom.).
XX
FF high levels in resting T cells, decreases after T-cell induction [6];
XX
IN T15204 brca1; Mammalia.
IN T08470 Daxx-isoform1; human, Homo sapiens.
IN T02944 Daxx; human, Homo sapiens.
IN T00325 Pit-1B; human, Homo sapiens.
IN T22434 Prox-1-isoform1; human, Homo sapiens.
IN T22440 Sp100-A; human, Homo sapiens.
IN T22415 Sp100; human, Homo sapiens.
XX
MX M00032 V$CETS1P54_01.
MX M00074 V$CETS1P54_02.
MX M01078 V$CETS1P54_03.
MX M02063 V$CETS1_02.
MX M01870 V$CETS1_Q6.
MX M00339 V$ETS1_B.
MX M08881 V$ETSLIKE_Q4.
MX M00340 V$ETS_B.
MX M00771 V$ETS_Q4.
MX M00971 V$ETS_Q6.
XX
BS R02153.
BS R73988.
BS R73934.
BS R14429.
BS R08269.
BS R00604.
BS R34568.
BS R34576.
BS R16924.
BS R26368.
BS R26369.
BS R14537.
BS R14800.
BS R13246.
BS R13247.
BS R73992.
BS R12728.
BS R17036.
BS R14156.
BS R02098.
BS R14790.
BS R16960.
BS R24064.
BS R08152.
BS R14623.
BS R14624.
BS R14625.
BS R14707.
BS R26190.
BS R01224.
BS R02924.
BS R74085.
BS R73935.
BS R18127.
BS R18128.
BS R18130.
XX
DR TRANSPATH: MO000018136.
DR TRANSCOMPEL: C00082.
DR TRANSCOMPEL: C00135.
DR TRANSCOMPEL: C00137.
DR TRANSCOMPEL: C00233.
DR TRANSCOMPEL: C00235.
DR TRANSCOMPEL: C00240.
DR TRANSCOMPEL: C00271.
DR TRANSCOMPEL: C00275.
DR TRANSCOMPEL: C00358.
DR TRANSCOMPEL: C00373.
DR TRANSCOMPEL: C00396.
DR TRANSCOMPEL: C00411.
DR EMBL: J04101; HSETS1A.
DR EMBL: X14798; HSCETS1.
DR EMBL: X55346; HSPROM.
DR UniProtKB: P14921-1;
XX
RN [1]; RE0000480.
RX PUBMED: 3136014.
RA Pognonec P., Boulukos K. E., Gesquiere J. C., Stehelin D., Ghysdael J.
RT Mitogenic stimulation of thymocytes results in the calcium-dependent phosphorylation of c-ets-1 proteins
RL EMBO J. 7:977-983 (1988).
RN [2]; RE0000614.
RX PUBMED: 2163347.
RA Gunther C. V., Nye J. A., Bryner R. S., Graves B. J.
RT Sequence-specific DNA binding of the proto-oncoprotein ets-1 defines a transcriptional activator sequence within the long terminal repeat of the Moloney murine sarcoma virus
RL Genes Dev. 4:667-679 (1990).
RN [3]; RE0000799.
RX PUBMED: 1592263.
RA Wasylyk C., Kerckaert J.-P., Wasylyk B.
RT A novel modulator domain of Ets transcription factors
RL Genes Dev. 6:965-974 (1992).
RN [4]; RE0001113.
RX PUBMED: 1517230.
RA Fisher R. J., Koizumi S., Kondoh A., Mariano J. M., Mavrothalassitis G., Bhat N. K., Papas T. S.
RT Human Ets1 oncoprotein
RL J. Biol. Chem. 267:17957-17965 (1992).
RN [5]; RE0001139.
RX PUBMED: 1964178.
RA Major E. O., Ameniya K., Elder G., Houff S. A.
RT Glial cells of the human developing brain and B cells of the immune system share a common DNA binding factor for recognition of the regulatroy sequences of the human polyomavirus, JCV
RL J. Neurosci. Res. 27:461-471 (1990).
RN [6]; RE0002411.
RX PUBMED: 2187191.
RA Bhat N. K., Thompson C. B., Lindsten T., June C. H., Fujiware S., Koizumi S., Fischer R. J., Papas T. S.
RT Reciprocal expression of human ETS1 and ETS2 genes during T-cell activation: Regulatory role for the protooncogene ETS1
RL Proc. Natl. Acad. Sci. USA 87:3723-3727 (1990).
RN [7]; RE0002650.
RX PUBMED: 2237431.
RA Ho I.-C., Bhat N. K., Gottschalk L. R., Lindsten R., Thompson C. B., Papas T. S., Leiden J. M.
RT Sequence-specific binding of human Ets-1 to the T cell receptor alpha gene enhancer
RL Science 250:814-818 (1990).
RN [8]; RE0005309.
RX PUBMED: 2997781.
RA Watson D. K., McWilliams-Smith M. J., Nunn M. F., Duesberg P. H., O'Brien S. J., Papas T. S.
RT The ets sequence from the transforming gene of avian erythroblastosis virus
RL Proc. Natl. Acad. Sci. USA 82:7294-7298 (1985).
RN [9]; RE0005310.
RX PUBMED: 2847145.
RA Watson D. K., McWilliams-Smith M. J., Lapis P., Lautenberger J. A., Schweinfest C. W., Papas T. S.
RT Mammalian ets-1 and ets-2 genes encode highly conserved proteins
RL Proc. Natl. Acad. Sci. USA 85:7862-7866 (1988).
RN [10]; RE0005311.
RX PUBMED: 2030910.
RA Jorcyk C. L., Watson D. K., Mavrothalassitis G. J., Papas T. S.
RT The human ETS1 gene: genomic structure, promoter characterization and alternative splicing
RL Oncogene 6:523-532 (1991).
RN [11]; RE0005312.
RX PUBMED: 3060801.
RA Reddy E. S. P., Rao V. N.
RT Structure, expression and alternative splicing of the human c-ets-1 proto-oncogene
RL Oncogene 3:239-246 (1988).
RN [12]; RE0047927.
RX PUBMED: 12242337.
RA Augustijn K. D., Duval D. L., Wechselberger R., Kaptein R., Gutierrez-Hartmann A., van der Vliet P. C.
RT Structural characterization of the PIT-1/ETS-1 interaction: PIT-1 phosphorylation regulates PIT-1/ETS-1 binding.
RL Proc. Natl. Acad. Sci. USA 99:12657-12662 (2002).
RN [13]; RE0048001.
RX PUBMED: 11909962.
RA Wasylyk C., Schlumberger S. E., Criqui-Filipe P., Wasylyk B.
RT Sp100 interacts with ETS-1 and stimulates its transcriptional activity.
RL Mol. Cell. Biol. 22:2687-2702 (2002).
RN [14]; RE0050611.
RX PUBMED: 10698492.
RA Li R., Pei H., Watson D. K., Papas T. S.
RT EAP1/Daxx interacts with ETS1 and represses transcriptional activation of ETS1 target genes.
RL Oncogene 19:745-753 (2000).
RN [15]; RE0067181.
RX PUBMED: 11313879.
RA Chai Y., Chipitsyna G., Cui J., Liao B., Liu S., Aysola K., Yezdani M., Reddy E. S., Rao V. N.
RT c-Fos oncogene regulator Elk-1 interacts with BRCA1 splice variants BRCA1a/1b and enhances BRCA1a/1b-mediated growth suppression in breast cancer cells.
RL Oncogene 20:1357-1367 (2001).
RN [16]; RE0022459.
RX PUBMED: 10644770.
RA Kas K., Finger E., Grall F., Gu X., Akbarali Y., Boltax J., Weiss A., Oettgen P., Kapeller R., Libermann T. A.
RT ESE-3, a novel member of an epithelium-specific ets transcription factor subfamily, demonstrates different target gene specificity from ESE-1.
RL J. Biol. Chem. 275:2986-2998 (2000).
XX
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