AC T22415
XX
ID T22415
XX
DT 14.12.2001 (created); ili.
DT 26.06.2013 (updated); prb.
CO Copyright (C), QIAGEN.
XX
FA Sp100
XX
SY Lysp100b; Nuclear autoantigen Sp-100; Nuclear dot-associated Sp100 protein; Speckled, 100 kDa.
XX
OS human, Homo sapiens
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; primates
XX
GE G002945 SP100; HGNC: SP100.
XX
CL C0077; SAND; 5.3.5.2.1.
XX
SF several isoforms;
XX
FF disrupts Bright binding to MAR-DNA at equivalent concentrations [1];
FF repression of Bright depends on the "conserved domain" [1];
FF nuclear autoantigen that localizes to promyelocytic leukemia (PML) nuclear bodies [1];
XX
IN T00112 c-Ets-1A; human, Homo sapiens.
IN T09585 CREM; human, Homo sapiens.
IN T06432 DRI1; mouse, Mus musculus.
XX
DR TRANSPATH: MO000056127.
DR SMARTDB: SB000069.
DR UniProtKB: P23497;
XX
RN [1]; RE0017413.
RX PUBMED: 10921892.
RA Zong R.-T., Das C., Tucker P. W.
RT Regulation of matrix attachment region-dependent, lymphocyte-restricted transcription through differential localization within promyelocytic leukemia nuclear bodies
RL EMBO J. 19:4123-4133 (2000).
RN [2]; RE0048001.
RX PUBMED: 11909962.
RA Wasylyk C., Schlumberger S. E., Criqui-Filipe P., Wasylyk B.
RT Sp100 interacts with ETS-1 and stimulates its transcriptional activity.
RL Mol. Cell. Biol. 22:2687-2702 (2002).
RN [3]; RE0048458.
RX PUBMED: 9412458.
RA Sternsdorf T., Jensen K., Will H.
RT Evidence for covalent modification of the nuclear dot-associated proteins PML and Sp100 by PIC1/SUMO-1.
RL J. Cell Biol. 139:1621-1634 (1997).
RN [4]; RE0048810.
RX PUBMED: 17000644.
RA Vertegaal A. C., Andersen J. S., Ogg S. C., Hay R. T., Mann M., Lamond A. I.
RT Distinct and overlapping sets of SUMO-1 and SUMO-2 target proteins revealed by quantitative proteomics.
RL Mol. Cell. Proteomics 5:2298-2310 (2006).
RN [5]; RE0066609.
RX PUBMED: 17062732.
RA Vlasakova J., Novakova Z., Rossmeislova L., Kahle M., Hozak P., Hodny Z.
RT Histone deacetylase inhibitors suppress IFNalpha-induced up-regulation of promyelocytic leukemia protein.
RL Blood 109:1373-1380 (2007).
XX
//