AC T06432
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ID T06432
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DT 03.02.2005 (created); elf.
DT 29.01.2010 (updated); jtr.
CO Copyright (C), QIAGEN.
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FA DRI1
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SY ARID domain-containing protein 3A; AT-rich interactive domain-containing protein 3A; B cell regulator of immunoglobulin heavy-chain transcription; B-cell regulator of IgH transcription; BRIGHT; Dead ringer like-1 protein.
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OS mouse, Mus musculus
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae
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GE G002328 Arid3a.
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CL C0048; ARID; 3.7.1.3.1.
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SF numerous phosphorylation sites [1];
SF binds as a tetramer [1];
SF possible alternative spliced forms [5];
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CP present in small pre-B cells, low levels in large pre-B cells (by RT-PCR) [5]; mature B cells, adult testis [1]; fetal thymus, liver and brain [5]; LPS-stimulated spleen [5]; adult bone marrow [5] [1] [5].
CN immature B cells [5]; T cell lines [1]; T cell lines [5]; adult liver [5] [1] [5].
EX Hypothalamus primordium,,,Theiler Stage 21; none; RNA-in situ hybridization (non-radioactive); RNA (undefined); [6].
EX central nervous system,,,Theiler Stage 21; detectable; RNA-in situ hybridization (non-radioactive); RNA (undefined); [6].
EX cerebral cortex,,,Theiler Stage 21; none; RNA-in situ hybridization (non-radioactive); RNA (undefined); [6].
EX cranial sensory ganglion,,,Theiler Stage 21; none; RNA-in situ hybridization (non-radioactive); RNA (undefined); [6].
EX ear,,,Theiler Stage 21; none; RNA-in situ hybridization (non-radioactive); RNA (undefined); [6].
EX epithelium of olfactory region of nasal cavity,,,Theiler Stage 21; detectable; RNA-in situ hybridization (non-radioactive); RNA (undefined); [6].
EX future corpus striatum,,,Theiler Stage 21; none; RNA-in situ hybridization (non-radioactive); RNA (undefined); [6].
EX mesencephalon,,,Theiler Stage 21; none; RNA-in situ hybridization (non-radioactive); RNA (undefined); [6].
EX retina,,,Theiler Stage 21; none; RNA-in situ hybridization (non-radioactive); RNA (undefined); [6].
EX rhombencephalon,,,Theiler Stage 21; none; RNA-in situ hybridization (non-radioactive); RNA (undefined); [6].
EX spinal cord,,,Theiler Stage 21; none; RNA-in situ hybridization (non-radioactive); RNA (undefined); [6].
EX subventricular zone of the MGE (medial ganglionic eminence),,,Theiler Stage 21; none; RNA-in situ hybridization (non-radioactive); RNA (undefined); [6].
EX thalamus,,,Theiler Stage 21; none; RNA-in situ hybridization (non-radioactive); RNA (undefined); [6].
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FF interacts with minor groove [1];
FF binding requires a minimum length of 13 bp [1];
FF binding site is composed of a core hexamer (RATWAA) and 2 closely spaced AT dimers [1];
FF binding sites need to be in the context of an active enhancer for trans-activation [1];
FF eliminated from its binding sites by NF-muNR/Cux/CDP [2];
FF distorts DNA to an angle of 80-90� [4];
FF overexpression induces increased DNase I hypersensitivity of the IgH mu enhancer [4];
FF localizes within the nuclear matrix [3];
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IN T22415 Sp100; human, Homo sapiens.
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MX M02839 V$ARID3A_02.
MX M02735 V$ARID3A_04.
MX M01654 V$DRI1_01.
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BS R29958.
BS R30293.
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DR TRANSPATH: MO000045580.
DR SMARTDB: SB000044.
DR UniProtKB: Q62431;
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RN [1]; RE0012159.
RX PUBMED: 8543152.
RA Herrscher R. F., Kaplan M. H., Lelsz D. L., Das C., Scheuermann R. H., Tucker P. W.
RT The immunoglobulin heavy-chain matrix-assocating regions are bound by Bright: a B cell-specific trans-activator that describes a new DNA-binding protein family
RL Genes Dev. 9:3067-3082 (1995).
RN [2]; RE0013403.
RX PUBMED: 9858552.
RA Wang Z., Goldstein A., Zong R. T., Lin D., Neufeld E. J., Scheuermann R. H., Tucker P. W.
RT Cux/CDP homeoprotein is a component of NF-muNR and represses the immunoglobulin heavy chain intronic enhancer by antagonizing the bright transcription activator
RL Mol. Cell. Biol. 19:284-295 (1999).
RN [3]; RE0017413.
RX PUBMED: 10921892.
RA Zong R.-T., Das C., Tucker P. W.
RT Regulation of matrix attachment region-dependent, lymphocyte-restricted transcription through differential localization within promyelocytic leukemia nuclear bodies
RL EMBO J. 19:4123-4133 (2000).
RN [4]; RE0017414.
RX PUBMED: 11294836.
RA Kaplan M. H., Zong R.-T., Herrscher R. F., Scheuermann R. H., Tucker P. W.
RT Transcriptional activation by a matrix associating region-binding protein
RL J. Biol. Chem. 276:21325-21330 (2001).
RN [5]; RE0017420.
RX PUBMED: 9590220.
RA Webb C. F., Smith E. A., Medina K. L., Buchanan K. L., Smithson G., Dou S.
RT Expression of Bright at two distinct stages of B lymphocyte development
RL J. Immunol. 160:4747-4754 (1998).
RN [6]; RE0025447.
RX PUBMED: 15618518.
RA Gray P. A., Fu H., Luo P., Zhao Q., Yu J., Ferrari A., Tenzen T., Yuk D. I., Tsung E. F., Cai Z., Alberta J. A., Cheng L. P., Liu Y., Stenman J. M., Valerius M. T., Billings N., Kim H. A., Greenberg M. E., McMahon A. P., Rowitch D. H., Stiles C. D., Ma Q.
RT Mouse brain organization revealed through direct genome-scale TF expression analysis.
RL Science 306:2255-2257 (2004).
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