AC T03961
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ID T03961
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DT 18.10.2000 (created); rio.
DT 12.08.2010 (updated); pch.
CO Copyright (C), QIAGEN.
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FA PMX2B
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SY NBPhox; paired mesoderm homeobox protein 2b.
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OS human, Homo sapiens
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; primates
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GE G001941 PHOX2B; HGNC: PHOX2B.
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HO Phox2b (mouse) T03976.
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CL C0006; homeo; 3.1.3.18.2.
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SF human PMX2B and homologous murine Phox2b T03976 differ only by a single amino acid substitution (G to A at position 292) [1];
SF interacts (probably with N-terminal activation domain) with the transcriptional co-activator CBP T01318 [2];
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CP (adult:) adrenal medulla, low levels in brain, (cell lines:) neuroblastoma cell line CHP134 [1].
CN (adult:) heart, placenta, lung, liver, skeletal muscle, kidney, pancreas, bone marrow, trachea, lymph node, spinal cord, thyroid, stomach [1].
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FF can activate gene expression of DBH (dopamine beta-hydroxylase) and c-Fos T00123 in response to both the PKA (protein kinase A) and PKC (protein kinase C) pathways [1];
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IN T01318 CBP; mouse, Mus musculus.
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MX M01356 V$PMX2B_01.
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BS R32372.
BS R15708.
BS R21173.
BS R21175.
BS R21176.
BS R23236.
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DR TRANSPATH: MO000027871.
DR UniProtKB: Q99453;
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RN [1]; RE0015200.
RX PUBMED: 10395798.
RA Yokoyama M., Watanabe H., Nakamura M.
RT Genomic structure and functional characterization of NBPhox (PMX2B), a homeodomain protein specific to catecholaminergic cells that is involved in second messenger-mediated transcriptional activation
RL Genomics 59:40-50 (1999).
RN [2]; RE0015252.
RX PUBMED: 10644760.
RA Swanson D. J., Adachi M., Lewis E. J.
RT The homeodomain protein Arix promotes protein kinase A-dependent activation of the dopamine beta-hydroxylase promoter through multiple elements and interaction with the coactivator cAMP-response element-binding protein-binding protein
RL J. Biol. Chem. 275:2911-2923 (2000).
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