TRANSFAC FACTOR TABLE, Release 2017.2 - public - 2017-06-30, (C) QIAGEN

AC T03961 XX ID T03961 XX DT 18.10.2000 (created); rio. DT 12.08.2010 (updated); pch. CO Copyright (C), QIAGEN. XX FA PMX2B XX SY NBPhox; paired mesoderm homeobox protein 2b. XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; primates XX GE G001941 PHOX2B; HGNC: PHOX2B. XX HO Phox2b (mouse) T03976. XX CL C0006; homeo; XX SF human PMX2B and homologous murine Phox2b T03976 differ only by a single amino acid substitution (G to A at position 292) [1]; SF interacts (probably with N-terminal activation domain) with the transcriptional co-activator CBP T01318 [2]; XX CP (adult:) adrenal medulla, low levels in brain, (cell lines:) neuroblastoma cell line CHP134 [1]. CN (adult:) heart, placenta, lung, liver, skeletal muscle, kidney, pancreas, bone marrow, trachea, lymph node, spinal cord, thyroid, stomach [1]. XX FF can activate gene expression of DBH (dopamine beta-hydroxylase) and c-Fos T00123 in response to both the PKA (protein kinase A) and PKC (protein kinase C) pathways [1]; XX IN T01318 CBP; mouse, Mus musculus. XX MX M01356 V$PMX2B_01. XX BS R32372. BS R15708. BS R21173. BS R21175. BS R21176. BS R23236. XX DR TRANSPATH: MO000027871. DR UniProtKB: Q99453; XX RN [1]; RE0015200. RX PUBMED: 10395798. RA Yokoyama M., Watanabe H., Nakamura M. RT Genomic structure and functional characterization of NBPhox (PMX2B), a homeodomain protein specific to catecholaminergic cells that is involved in second messenger-mediated transcriptional activation RL Genomics 59:40-50 (1999). RN [2]; RE0015252. RX PUBMED: 10644760. RA Swanson D. J., Adachi M., Lewis E. J. RT The homeodomain protein Arix promotes protein kinase A-dependent activation of the dopamine beta-hydroxylase promoter through multiple elements and interaction with the coactivator cAMP-response element-binding protein-binding protein RL J. Biol. Chem. 275:2911-2923 (2000). XX //