AC T03976
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ID T03976
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DT 23.10.2000 (created); rio.
DT 06.04.2009 (updated); djp.
CO Copyright (C), QIAGEN.
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FA PMX2B
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SY NBPhox; paired-like homeobox 2b.
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OS mouse, Mus musculus
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae
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GE G001949 Phox2b.
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HO Pmx2b (human) T03961.
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CL C0006; homeo; 3.1.3.18.2.
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SF murine PMX2B and homologous human Pmx2b T03961 differ only by a single amino acid substitution (A to G at position 292) [1];
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CP embryonic neurons, predominantly (nor)adrenergic cells [2].
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FF can activate gene expression of DBH (dopamine beta-hydroxylase) and c-fos in response to both the PKA (protein kinase A) and PKC (protein kinase C) pathways [1];
FF in embryonic neurons is coexpressed with Hox11L2 [2];
FF is required for the formation of brainstem (nor)adrenergetic neurons, together with Hox11L2 and Mash1 [2];
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MX M01356 V$PMX2B_01.
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DR TRANSPATH: MO000027886.
DR UniProtKB: O35690;
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RN [1]; RE0015200.
RX PUBMED: 10395798.
RA Yokoyama M., Watanabe H., Nakamura M.
RT Genomic structure and functional characterization of NBPhox (PMX2B), a homeodomain protein specific to catecholaminergic cells that is involved in second messenger-mediated transcriptional activation
RL Genomics 59:40-50 (1999).
RN [2]; RE0023844.
RX PUBMED: 11581159.
RA Qian Y., Fritzsch B., Shirasawa S., Chen C. L., Choi Y., Ma Q.
RT Formation of brainstem (nor)adrenergic centers and first-order relay visceral sensory neurons is dependent on homeodomain protein Rnx/Tlx3.
RL Genes Dev. 15:2533-2545 (2001).
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