TRANSFAC FACTOR TABLE, Release 2017.2 - public - 2017-06-30, (C) QIAGEN

AC T03976 XX ID T03976 XX DT 23.10.2000 (created); rio. DT 06.04.2009 (updated); djp. CO Copyright (C), QIAGEN. XX FA PMX2B XX SY NBPhox; paired-like homeobox 2b. XX OS mouse, Mus musculus OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae XX GE G001949 Phox2b. XX HO Pmx2b (human) T03961. XX CL C0006; homeo; XX SF murine PMX2B and homologous human Pmx2b T03961 differ only by a single amino acid substitution (A to G at position 292) [1]; XX CP embryonic neurons, predominantly (nor)adrenergic cells [2]. XX FF can activate gene expression of DBH (dopamine beta-hydroxylase) and c-fos in response to both the PKA (protein kinase A) and PKC (protein kinase C) pathways [1]; FF in embryonic neurons is coexpressed with Hox11L2 [2]; FF is required for the formation of brainstem (nor)adrenergetic neurons, together with Hox11L2 and Mash1 [2]; XX MX M01356 V$PMX2B_01. XX DR TRANSPATH: MO000027886. DR UniProtKB: O35690; XX RN [1]; RE0015200. RX PUBMED: 10395798. RA Yokoyama M., Watanabe H., Nakamura M. RT Genomic structure and functional characterization of NBPhox (PMX2B), a homeodomain protein specific to catecholaminergic cells that is involved in second messenger-mediated transcriptional activation RL Genomics 59:40-50 (1999). RN [2]; RE0023844. RX PUBMED: 11581159. RA Qian Y., Fritzsch B., Shirasawa S., Chen C. L., Choi Y., Ma Q. RT Formation of brainstem (nor)adrenergic centers and first-order relay visceral sensory neurons is dependent on homeodomain protein Rnx/Tlx3. RL Genes Dev. 15:2533-2545 (2001). XX //