TRANSFAC FACTOR TABLE, Release 2017.2 - public - 2017-06-30, (C) QIAGEN

AC T00100 XX ID T00100 XX DT 15.10.1992 (created); ewi. DT 21.08.2014 (updated); yre. CO Copyright (C), QIAGEN. XX FA CDP XX SY CASP; CCAAT displacement protein; CDP; CDP/Cut; CDP1; Clox; COY1; cut homeodomain protein; cut-like 1, CCAAT displacement protein (Drosophila); cut-like homeobox 1; cut-like homeodomain protein; Cutl1; Cux; Cux/CDP; Cux1; FLJ31745; GOLIM6; Nbla10317; p100; p110; p200; p75; Protein CASP. XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; primates XX GE G004658 CUX1; HGNC: Cux1. XX HO cut (Drosophila) T02004. XX CL C0006; homeo; XX SF the Clox homolog is a splice variant [6]; SF the 3 cut repeats also contribute to DNA-binding, each individual repeat and each combination exhibiting slightly different DNA-binding specificity [5] [6] [7]; SF CR1 exhibits the most restricted recognition pattern [5]; SF KD (CR3-homeo domain) = 0.03 nM, isolated CR3 at least 100-fold lower affinity [7]; XX CP HeLa and U937 [19]. CN Circulating monocytes [19]. XX FF repressor [3] [8] [9] [10] [2] [1]; FF transcription factor, look up the TRANSFAC cross reference for more details; FF may regulate S/MAR-binding factor SATB1 and may be regulated by it via protein-protein interaction [13]; XX IN T08499 CBP; mouse, Mus musculus. IN T09570 E2F-1; Mammalia. IN T17403 E2F-2; Mammalia. IN T34364 G9A; human, Homo sapiens. IN T04106 HDAC1; human, Homo sapiens. IN T05056 Max; human, Homo sapiens. IN T08711 RelA-p65; human, Homo sapiens. IN T10386 SATB1; human, Homo sapiens. IN T17579 SATB1; mouse, Mus musculus. IN T17580 SATB1; mouse, Mus musculus. XX MX M00104 V$CDPCR1_01. MX M00106 V$CDPCR3HD_01. MX M00105 V$CDPCR3_01. MX M00095 V$CDP_01. MX M00102 V$CDP_02. MX M01342 V$CDP_03. MX M01344 V$CDP_04. MX M04610 V$CDP_Q6_01. MX M03952 V$CUX1_07. XX BS R20770. BS R04681. BS R04723. BS R04721. BS R04720. BS R55733. BS R35714. BS R58458. BS R34456. BS R03477. BS R20791. BS R20793. BS R20794. BS R20999. BS R21008. BS R35837. BS R61202. BS R61204. BS R61205. BS R61207. BS R00562. BS R60669. BS R34455. BS R61174. BS R61189. BS R36022. BS R35914. BS R25883. BS R61213. BS R61214. BS R01677. BS R35825. XX DR TRANSPATH: MO000024708. DR SMARTDB: SB000079. DR UniProtKB: P39880; CDP_HUMAN. DR UniProtKB: Q13948; CASP_HUMAN. XX RN [1]; RE0000079. RX PUBMED: 3607873. RA Barberis A., Superti-Furga G., Busslinger M. RT Mutually Exclusive Interaction of the CCAAT-Binding Factor and of a Displacement Protein with Overlapping Sequences of a Histone Gene Promoter RL Cell 50:347-359 (1987). RN [2]; RE0000346. RX PUBMED: 3181130. RA Superti-Furga G., Barberis A., Schaffner G., Busslinger M. RT The -117 mutation in Greek HPFH affects the binding of three nuclear factors to the CCAAT region of the gamma-globin gene RL EMBO J. 7:3099-3107 (1988). RN [3]; RE0001031. RX PUBMED: 1885602. RA Skalnik D. G., Strauss E. C., Orkin S. H. RT CCAAT displacement protein as a repressor of the myelomonocytic-specific gp91-phox gene promoter RL J. Biol. Chem. 266:16736-16744 (1991). RN [4]; RE0002047. RX PUBMED: 2476717. RA Mantovani R., Superti-Furga G., Gilman J., Ottolenghi S. RT The deletion of the distal CCAAT box region of the Agamma-globin gene in black HPFH abolishes the binding of the erythroid specific protein NFE3 and of the CCAAT displacement protein RL Nucleic Acids Res. 17:6681-6691 (1989). RN [5]; RE0002967. RX PUBMED: 7914370. RA Aufiero B., Neufeld E. J., Orkin S. H. RT Sequence-specific DNA binding of individual cut repeats of the human CCAAT displacement/ cut homeodomain protein RL Proc. Natl. Acad. Sci. USA 91:7757-7761 (1994). RN [6]; RE0002972. RX PUBMED: 7905452. RA Andres V., Chiara M. D., Mahdavi V. RT A new bipartite DNA-binding domain: cooperative interaction between the cut repeat and homeo domain of the cut homeo proteins RL Genes Dev. 8:245-257 (1994). RN [7]; RE0002973. RX PUBMED: 7799919. RA Harada R., Berube G., Tamplin O. J., Denis-Larose C., Nepveu A. RT DNA-binding specificity of the cut repeats from the human cut-like protein RL Mol. Cell. Biol. 15:129-140 (1995). RN [8]; RE0003358. RX PUBMED: 8196661. RA Dufort D., Nepveu A. RT The human Cut homeodomain protein represses transcription from the c-myc promoter RL Mol. Cell. Biol. 14:4251-4257 (1994). RN [9]; RE0003999. RX PUBMED: 7759529. RA Lievens P. M., Donady J. J., Tufarelli C., Neufeld E. J. RT Repressor activity of CCAAT displacement protein in HL-60 myeloid leukemia cells RL J. Biol. Chem. 270:12745-12750 (1995). RN [10]; RE0005002. RX PUBMED: 1301999. RA Neufeld E. J., Skalnik D. G., Lievens P. M., Orkin S. H. RT Human CCAAT dis-placement protein is homologous to the Drosophila homeoprotein, cut RL Nat. Genet. 1:50-55 (1992). RN [11]; RE0005004. RX PUBMED: 7904999. RA Harada R., Dufort D., Denis-Larose C., Nepveu A. RT Conserved cut repeats in the human cut homeodomain protein function as DNA binding domains RL J. Biol. Chem. 269:2062-2067 (1994). RN [12]; RE0005005. RX PUBMED: 2784063. RA Superti-Furga G., Barberis A., Schaffner G., Busslinger M. RT The protein CDP, but not CP1, footprints on the CCAAT region of the g-globin gene in unfractionated B-cell extracts RL Biochim. Biophys. Acta 1007:237-242 (1989). RN [13]; RE0015021. RX PUBMED: 10373541. RA Liu J., Barnett A., Neufeld E. J., Dudley J. P. RT Homeoproteins CDP and SATB1interact: potential for tissue-specific regulation RL Mol. Cell. Biol. 19:4918-4926 (1999). RN [14]; RE0017514. RX PUBMED: 11584018. RA Santaguida M., Ding Q., Berube G., Truscott M., Whyte P., Nepveu A. RT Phosphorylation of the CCAAT displacement protein (CDP)/Cux transcription factor by cyclin A-Cdk1 modulates its DNA binding activity in G(2). RL J. Biol. Chem. 276:45780-45790 (2001). RN [15]; RE0017861. RX PUBMED: 10684263. RA Stuenkel W., Huang Z., Tan S.-H., O'Connor M. J., Bernard H.-U. RT Nuclear matrix attachment regions of human papillomavirus type 16 repress or activate the E6 promoter, depending on the physical state of the viral DNA RL J. Virol. 74:2489-2501 (2000). RN [16]; RE0042400. RX PUBMED: 10852958. RA Li S., Aufiero B., Schiltz R. L., Walsh M. J. RT Regulation of the homeodomain CCAAT displacement/cut protein function by histone acetyltransferases p300/CREB-binding protein (CBP)-associated factor and CBP RL Proc. Natl. Acad. Sci. USA 97:7166-71 (2000). RN [17]; RE0048983. RX PUBMED: 15269344. RA Nishio H., Walsh M. J. RT CCAAT displacement protein/cut homolog recruits G9a histone lysine methyltransferase to repress transcription. RL Proc. Natl. Acad. Sci. USA 101:11257-11262 (2004). RN [18]; RE0053184. RX PUBMED: 18256137. RA Stratigopoulos G., Padilla S. L., LeDuc C. A., Watson E., Hattersley A. T., McCarthy M. I., Zeltser L. M., Chung W. K., Leibel R. L. RT Regulation of Fto/Ftm gene expression in mice and humans. RL Am. J. Physiol. Regul. Integr. Comp. Physiol. 294:R1185-96 (2008). RN [19]; RE0049573. RX PUBMED: 9885213. RA Marziali G., Perrotti E., Ilari R., Coccia E. M., Mantovani R., Testa U., Battistini A. RT The activity of the CCAAT-box binding factor NF-Y is modulated through the regulated expression of its A subunit during monocyte to macrophage differentiation: regulation of tissue-specific genes through a ubiquitous transcription factor. RL Blood 93:519-526 (1999). XX //