DT 01.01.1999 (created); ili.
DT 11.08.2014 (updated); yre.
CO Copyright (C), QIAGEN.
SY L2a-P1; special AT-rich sequence binding protein 1.
OS mouse, Mus musculus
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae
GE G002305 Satb1.
HO human SATB1.
CL C0006; homeo; 18.104.22.168.1.
SF phosphorylated ;
SF binds as a monomer ;
SF shares 67% overall sequence homology with SATB2 ;
CP predominantly in thymus .
FF has a cage-like 'network' distribution in thymocyte nuclei ;
FF its 'network' resists salt extraction ;
FF in thymocytes all in vivo SATB1 binding sites become chromatin-loop bases by anchoring to its network, thereby genes found within 4-60 kB of the binding sites become inducible on stimulation while others are activated or repressed ;
FF shown to mediate the formation of a special histone code over a restricted region containing genes whose expression is SATB1-dependent ;
FF assembles protein complexes containing factors found in CHRAC/ACF and NURD complexes ;
FF ablation leads to dysregulated transcription of IL-7Ralpha, IL-2Ralpha, Mig, c-myc, APC, TSG101, T160, GABP, PD-1 RIP and TDAG51 genes in thymocytes ;
FF necessary for T-cell development and function ;
FF knockout mice showed growth retardation as early as 3 days after birth, had much smaller thymus, spleen and lymph nodes than wild type mice and did not survive weaning ;
FF may have a role in neurological function ;
FF interacts in vitro and in vivo with CDP T00100 ;
FF may regulate CDP and may be regulated by CDP T00100 via protein-protein interaction ;
IN T00100 CDP; human, Homo sapiens.
IN T23418 HDAC1; mouse, Mus musculus.
IN T14288 PLZF; Mammalia.
IN T01836 Sox-2; mouse, Mus musculus.
MX M01723 V$SATB1_Q3.
MX M03564 V$SATB1_Q5_01.
DR TRANSPATH: MO000056071.
DR SMARTDB: SB000001.
DR UniProtKB: Q60611; SAB1_MOUSE.
RN ; RE0006986.
RX PUBMED: 8114718.
RA Nakagomi K., Kohwi Y., Dickinson L. A., Kohwi-Shigematsu T.
RT A novel DNA-binding motif in the nuclear matrix attachment DNA-binding protein SATB1
RL Mol. Biol. Cell 14:1852-1860 (1994).
RN ; RE0007005.
RX PUBMED: 7559473.
RA Wang B., Dickinson L. A., Koivunen E., Ruoslahti E., Kohwi-Shigematsu T.
RT A novel matrix attachment region DNA binding motif identified using a random phage peptide library
RL J. Biol. Chem. 270:23239-23242 (1995).
RN ; RE0007007.
RX PUBMED: 7799955.
RA Dickinson L. A., Kohwi-Shigematsu T.
RT Nucleolin is a matrix attachment region DNA-binding protein that specifically recognizes a region with high base-unpairing potential
RL Mol. Cell. Biol. 15:456-465 (1995).
RN ; RE0007081.
RX PUBMED: 9218488.
RA Banan M., Rojas I. C., Lee W. H., King H. L., Harriss J.V., Kobayashi R., Web C. F., Gottlieb P. D.
RT Interaction of the nuclear matrix-associated region (MAR)-binding proteins, SATB1 and CDP/Cux, with a MAR element (L2a) in an upstream regulatory region of the mouse CD8a gene
RL J. Biol. Chem. 272:18440-18452 (1997).
RN ; RE0014989.
RX PUBMED: 10716941.
RA Alvarez J. D., Yasui D. H., Niida H., Joh T., Loh D. Y., Kohwi-Shigematsu T.
RT The MAR-binding protein SATB1 orchestrates temporal and spatial expression of multiple genes during T-cell development
RL Genes Dev. 14:521-535 (2000).
RN ; RE0015021.
RX PUBMED: 10373541.
RA Liu J., Barnett A., Neufeld E. J., Dudley J. P.
RT Homeoproteins CDP and SATB1interact: potential for tissue-specific regulation
RL Mol. Cell. Biol. 19:4918-4926 (1999).
RN ; RE0015033.
RX PUBMED: 9792700.
RA Chattopadhyay S., Whitehurst C. E., Chen J.
RT A nuclear matrix attachment region upstream of the T cell receptor beta gene enhancer binds Cux/CDP and SATB1 and modulates enhancer-dependent reporter gene expression but not endogenous gene expression
RL J. Biol. Chem. 273:29838-29846 (1998).
RN ; RE0023958.
RX PUBMED: 12692553.
RA Cai S., Han H.-J., Kohwi-Shigematsu T.
RT Tissue-specific nuclear architecture and gene expression regulated by SATB1
RL Nat. Genet. 34:42-51 (2003).
RN ; RE0023973.
RX PUBMED: 12374985.
RA Yasui D., Miyano M., Cai S., Varga-Weisz P., Kohwi-Shigematsu T.
RT SATB1 targets chromatin remodelling to regulate genes over long distances
RL Nature 419:641-645 (2002).
RN ; RE0025191.
RX PUBMED: 14701874.
RA Dobreva G., Dambacher J., Grosschedl R.
RT SUMO modification of a novel MAR-binding protein, SATB2, modulates immunoglobulin mu gene expression
RL Genes Dev. 17:3048-3061 (2003).