AC T01836
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ID T01836
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DT 23.05.1996 (created); ewi.
DT 11.01.2016 (updated); mkl.
CO Copyright (C), QIAGEN.
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FA Sox-2
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SY Fx; Sox-2.
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OS mouse, Mus musculus
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae
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GE G006750 Sox2.
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CL C0015; HMG; 4.1.1.2.2.
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SF homologous sequence to chick Sox-2;
SF usage of an upstream Met codon may lead to an N-terminal extension of 4 AA [3];
SF additionally, there is an internal substitution in Ref. [3];
SF ternary complexes with either Oct-1 or with embryonal Oct-3/Oct-4 [3];
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CP highest level in brain, retina, lower in lung, stomach [3]; urogenital ridge, developing CNS [1] [1] [3]; highly expressed in undifferentiated MG1.19 and RF8 ES cells, weak expression in testis and stomach [8].
CN kidney, liver, spleen, testis [3]; not expressed in differentiated cells (COS7 cells) [8].
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FF probably an architectural component of transcription complexes, supporting activation by Oct-3/Oct-4, but not by Oct-1 [3];
FF Sox-2 interferes with Oct4 T00651mediated transcriptional activation [7];
FF Sox-2 may decrease the level of OPN expression in ES cells [7];
FF binding of Sox-2 protein to the canonical Sox motif is required for its repressive effect R16367 [7];
FF the transcriptional repression by Sox-2 is not likely attributable to competitive binding of Sox-2 with another transcription factor, rather it is the result of the carboxy-terminal region of Sox-2 that interferes with Oct4 T00651 mediated transcriptional activation [7];
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IN T19229 DRRS; mouse, Mus musculus.
IN T08969 nanog; mouse, Mus musculus.
IN T18507 nanog; Mammalia.
IN T00651 Oct3; mouse, Mus musculus.
IN T09363 Oct3; mouse, Mus musculus.
IN T14488 PARP; mouse, Mus musculus.
IN T17580 SATB1; mouse, Mus musculus.
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MX M02246 V$SOX2_01.
MX M07225 V$SOX2_06.
MX M03886 V$SOX2_Q3.
MX M07308 V$SOX2_Q3_01.
MX M07432 V$SOX2_Q4.
MX M01272 V$SOX2_Q6.
MX M08899 V$SOX_Q4.
MX M01014 V$SOX_Q6.
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BS R27940.
BS R27933.
BS R72446.
BS R72416.
BS R72443.
BS R39808.
BS R39811.
BS R39812.
BS R39814.
BS R39815.
BS R60655.
BS R64906.
BS R72442.
BS R69661.
BS R61703.
BS R19276.
BS R15139.
BS R22359.
BS R42013.
BS R42019.
BS R22463.
BS R23679.
BS R68045.
BS R19260.
BS R19510.
BS R66100.
BS R17099.
BS R22961.
BS R16367.
BS R65791.
BS R64733.
BS R64734.
BS R15133.
BS R42017.
BS R42018.
BS R67436.
BS R67437.
BS R67438.
BS R67439.
BS R22342.
BS R22344.
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DR TRANSPATH: MO000025968.
DR TRANSCOMPEL: C00454.
DR TRANSCOMPEL: C00459.
DR TRANSCOMPEL: C00461.
DR TRANSCOMPEL: C00464.
DR TRANSCOMPEL: C00476.
DR TRANSCOMPEL: C00479.
DR TRANSCOMPEL: C00484.
DR TRANSCOMPEL: C00502.
DR TRANSCOMPEL: C00586.
DR UniProtKB: P48432;
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RN [1]; RE0004337.
RX PUBMED: 8625802.
RA Collignon J., Sockanathan S., Hacker A., Cohen-Tannoudji M., Norris D., Rastan S., Stevanovic M., Goodfellow P. N., Lovell-Badge R.
RT A comparison of the properties of Sox-3 with Sry and two related genes, Sox-1 and Sox-2
RL Development 122:509-520 (1996).
RN [2]; RE0004338.
RX PUBMED: 7628452.
RA Kamachi Y., Sockanathan S., Liu Q., Breitman M., Lovell-Badge R., Kondoh H.
RT Involvement of SOX proteins in lens-specific activation of crystallin genes
RL EMBO J. 14:3510-3519 (1995).
RN [3]; RE0004339.
RX PUBMED: 7590241.
RA Yuan H., Corbi N., Basilico C., Dailey L.
RT Developmental-specific activity of the FGF-4 enhancer requires the synergistic action of Sox2 and Oct-3
RL Genes Dev. 9:2635-2345 (1995).
RN [4]; RE0004340.
RX PUBMED: 8441686.
RA Wright E. M., Snopek B., Koopman P.
RT Seven new members of the Sox gene family expressed during mouse development
RL Nucleic Acids Res. 21:744-744 (1993).
RN [5]; RE0004341.
RX PUBMED: 1614875.
RA Denny P., Swift S., Brand N., Dabhade N., Barton P., Ashworth A.
RT A conserved family of genes related to the testis determining gene, SRY
RL Nucleic Acids Res. 20:2887-2887 (1992).
RN [6]; RE0024364.
RX PUBMED: 9343393.
RA Ambrosetti D. C., Basilico C., Dailey L.
RT Synergistic activation of the fibroblast growth factor 4 enhancer by Sox2 and Oct-3 depends on protein-protein interactions facilitated by a specific spatial arrangement of factor binding sites.
RL Mol. Cell. Biol. 17:6321-6329 (1997).
RN [7]; RE0025446.
RX PUBMED: 9649510.
RA Botquin V., Hess H., Fuhrmann G., Anastassiadis C., Gross M. K., Vriend G., Scholer H. R.
RT New POU dimer configuration mediates antagonistic control of an osteopontin preimplantation enhancer by Oct-4 and Sox-2.
RL Genes Dev. 12:2073-2090 (1998).
RN [8]; RE0050892.
RX PUBMED: 15863505.
RA Maruyama M., Ichisaka T., Nakagawa M., Yamanaka S.
RT Differential roles for Sox15 and Sox2 in transcriptional control in mouse embryonic stem cells.
RL J. Biol. Chem. 280:24371-24379 (2005).
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