AC T17579
XX
ID T17579
XX
DT 30.05.2006 (created); ili.
DT 03.01.2007 (updated); sou.
CO Copyright (C), QIAGEN.
XX
FA SATB1
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SY L2a-P1; special AT-rich sequence binding protein 1.
XX
OS mouse, Mus musculus
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae
XX
GE G002305 Satb1.
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CL C0006; homeo; 3.1.9.3.1.1.
XX
SZ 764 AA; 85.9 kDa (cDNA) (calc.), 103 kDa (SDS) [1]
XX
SQ MDHLNEATQGKEHSEMSNNVSDPKGPPAKIARLEQNGSPLGRGRLGSTGGKMQGVPLKHS
SQ GHLMKTNLRKGTMLPVFCVVEHYENAIEYDCKEEHAEFVLVRKDMLFNQLIEMALLSLGY
SQ SHSSAAQAKGLIQVGKWNPVPLSYVTDAPDATVANMLQDVYHVVTLKIQLHSCPKLEDLP
SQ PEQWSHTTVRNALKDLLKDMNQSSLAKECPLSQSMISSIVNSTYYANVSAAKCQEFGRWY
SQ KHFKKTKDMMVEMDSLSELSQQGANHVNFGQQPVPGNTAEQPPSPAQLSHGSQPSVRTPL
SQ PNLHPGLVSTPISPQLVNQQLVMAQLLNQQYAVNRLLAQQSLNQQYLNHPPPVSRSMNKP
SQ LEQQVSTNTEVSSEIYQWVRDELKRAGISQAVFARVAFNRTQGLLSEILRKEEDPKTASQ
SQ SLLVNLRAMQNFLQLPEAERDRIYQDERERSLNAASAMGPAPLLSTPPSRPPQVKTATLA
SQ TERNGKPENNTMNINASIYDEIQQEMKRAKVSQAPFAKVAATKSQGWLCELLRWKEDPSP
SQ ENRTLWENLSMIRRFLSLPQPERDAIYEQESNAVHHHGDRPPHIIHVPAEQIQQQQQQQQ
SQ QQQQQQQPPPPPPQPQPQPQAGPRLPPRQPTVASSAESDEENRQKTRPRTKISVEALGIL
SQ QSFIQDVGLYPDEEAIQTLSAQLDLPKYTIIKFFQNQRYYLKHHGKLKDNSGLEVDVAEY
SQ KDEELLKDLEESVQDKNANTLFSVKLEEELSVEGSTDVNADLKD
XX
SC translated from EMBL #U05252
XX
FT 71 398 
PF00478; IMP dehydrogenase / GMP reductase domain.
FT 298 394 
essential for association with transcription factor CDP T00100 [6].
FT 346 495 
DNA-binding domain [1].
FT 355 363 
important for DNA binding [2].
FT 361 448 
PS51042; CUT.
FT 362 448 
CUT domain [10].
FT 362 448 
PF02376; CUT domain.
FT 484 571 
CUT domain [10].
FT 484 571 
PF02376; CUT domain.
FT 484 571 
PS51042; CUT.
FT 593 607 Q-stretch [1].
FT 643 704 PS50071; HOMEOBOX_2.
FT 643 705 PS50560; CUT_HOMEODOMAIN.
FT 645 708 SM00389; HOX_1.
FT 646 705 HOX domain [10].
FT 646 703 PF00046; Homeobox domain.
XX
IN T00100 CDP; human, Homo sapiens.
XX
MX M01723 V$SATB1_Q3.
XX
DR TRANSPATH: MO000082143.
DR SMARTDB: SB000134.
DR EMBL: U05252; MM05252.
DR UniProtKB: Q60611; SAB1_MOUSE.
XX
RN [1]; RE0006986.
RX PUBMED: 8114718.
RA Nakagomi K., Kohwi Y., Dickinson L. A., Kohwi-Shigematsu T.
RT A novel DNA-binding motif in the nuclear matrix attachment DNA-binding protein SATB1
RL Mol. Biol. Cell 14:1852-1860 (1994).
RN [2]; RE0007005.
RX PUBMED: 7559473.
RA Wang B., Dickinson L. A., Koivunen E., Ruoslahti E., Kohwi-Shigematsu T.
RT A novel matrix attachment region DNA binding motif identified using a random phage peptide library
RL J. Biol. Chem. 270:23239-23242 (1995).
RN [3]; RE0007007.
RX PUBMED: 7799955.
RA Dickinson L. A., Kohwi-Shigematsu T.
RT Nucleolin is a matrix attachment region DNA-binding protein that specifically recognizes a region with high base-unpairing potential
RL Mol. Cell. Biol. 15:456-465 (1995).
RN [4]; RE0007081.
RX PUBMED: 9218488.
RA Banan M., Rojas I. C., Lee W. H., King H. L., Harriss J.V., Kobayashi R., Web C. F., Gottlieb P. D.
RT Interaction of the nuclear matrix-associated region (MAR)-binding proteins, SATB1 and CDP/Cux, with a MAR element (L2a) in an upstream regulatory region of the mouse CD8a gene
RL J. Biol. Chem. 272:18440-18452 (1997).
RN [5]; RE0014989.
RX PUBMED: 10716941.
RA Alvarez J. D., Yasui D. H., Niida H., Joh T., Loh D. Y., Kohwi-Shigematsu T.
RT The MAR-binding protein SATB1 orchestrates temporal and spatial expression of multiple genes during T-cell development
RL Genes Dev. 14:521-535 (2000).
RN [6]; RE0015021.
RX PUBMED: 10373541.
RA Liu J., Barnett A., Neufeld E. J., Dudley J. P.
RT Homeoproteins CDP and SATB1interact: potential for tissue-specific regulation
RL Mol. Cell. Biol. 19:4918-4926 (1999).
RN [7]; RE0015033.
RX PUBMED: 9792700.
RA Chattopadhyay S., Whitehurst C. E., Chen J.
RT A nuclear matrix attachment region upstream of the T cell receptor beta gene enhancer binds Cux/CDP and SATB1 and modulates enhancer-dependent reporter gene expression but not endogenous gene expression
RL J. Biol. Chem. 273:29838-29846 (1998).
RN [8]; RE0023958.
RX PUBMED: 12692553.
RA Cai S., Han H.-J., Kohwi-Shigematsu T.
RT Tissue-specific nuclear architecture and gene expression regulated by SATB1
RL Nat. Genet. 34:42-51 (2003).
RN [9]; RE0023973.
RX PUBMED: 12374985.
RA Yasui D., Miyano M., Cai S., Varga-Weisz P., Kohwi-Shigematsu T.
RT SATB1 targets chromatin remodelling to regulate genes over long distances
RL Nature 419:641-645 (2002).
RN [10]; RE0025191.
RX PUBMED: 14701874.
RA Dobreva G., Dambacher J., Grosschedl R.
RT SUMO modification of a novel MAR-binding protein, SATB2, modulates immunoglobulin mu gene expression
RL Genes Dev. 17:3048-3061 (2003).
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