AC T08420
XX
ID T08420
XX
DT 18.01.2006 (created); anu.
DT 15.12.2014 (updated); ros.
CO Copyright (C), QIAGEN.
XX
FA c-Ets-1
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SY c-Ets-1; Ets1; p54.
XX
OS mouse, Mus musculus
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae
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GE G006040 Ets1.
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CL C0016; ETS; 3.5.2.1.1.1.
XX
SZ 440 AA; 50.2 kDa (cDNA) (calc.), 66 kDa (SDS)
XX
SQ MKAAVDLKPTLTIIKTEKVDLELFPSPDMECADVPLLTPSSKEMMSQALKATFSGFTKEQ
SQ QRLGIPKDPRQWTETHVRDWVMWAVNEFSLKGVDFQKFCMSGAALCALGKECFLELAPDF
SQ VGDILWEHLEILQKEDVKPYQVNGANPTYPESCYTSDYFISYGIEHAQCVPPSEFSEPSF
SQ ITESYQTLHPISSEELLSLKYENDYPSVILQDPLQTDTLQTDYFAIKQEVLTPDNMCLGR
SQ ASRGKLGGQDSFESVESYDSCDRLTQSWSSQSSFNSLQRVPSYDSFDYEDYPAALPNHKP
SQ KGTFKDYVRDRADLNKDKPVIPAAALAGYTGSGPIQLWQFLLELLTDKSCQSFISWTGDG
SQ WEFKLSDPDEVARRWGKRKNKPKMNYEKLSRGLRYYYDKNIIHKTAGKRYVYRFVCDLQS
SQ LLGYTPEELHAMLDVKPDAD
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SC translated from EMBL:BC010588
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FT 53 136 
PF02198; Sterile alpha motif (SAM)/Pointed domain.
FT 53 136 
SM00251; SAM2_3.
FT 54 132 
PNT domain (POINTED) [1].
FT 68 134 
POINTED domain of homology [9].
FT 114 120 
LXLXXXF motif of PNT domain involved in ERK2 docking. [1].
FT 123 240 
interaction with murine PEBP2alphaA1 [11].
FT 334 417 
PF00178; Ets-domain.
FT 334 419 
SM00413; etsneu2.
FT 335 415 
PS50061; ETS_DOMAIN_3.
FT 337 405 
PS50140; HSF_ETS.
FT 388 395 essential DNA contacts [10].
FT 398 399 interaction with Pax-5 [10].
FT 423 440 repression of DNA-binding [8].
XX
IN T08499 CBP; mouse, Mus musculus.
IN T10639 HMGIY; Mammalia.
XX
MX M00032 V$CETS1P54_01.
MX M00074 V$CETS1P54_02.
MX M01078 V$CETS1P54_03.
MX M01986 V$CETS1_01.
MX M01870 V$CETS1_Q6.
MX M00339 V$ETS1_B.
MX M08881 V$ETSLIKE_Q4.
MX M00340 V$ETS_B.
MX M00771 V$ETS_Q4.
MX M00971 V$ETS_Q6.
XX
BS R33798.
BS R02153.
BS R17177.
BS R04450.
BS R26370.
BS R26371.
BS R26372.
BS R26373.
BS R26374.
BS R26375.
BS R33546.
BS R60656.
BS R60657.
BS R60658.
BS R60660.
BS R19142.
BS R19143.
BS R56498.
BS R18140.
BS R18141.
BS R18142.
BS R01155.
BS R01156.
BS R39545.
BS R39546.
BS R39551.
XX
DR TRANSPATH: MO000057516.
DR EMBL: BC010588;
DR EMBL: M58482;
DR EMBL: X53953;
DR EMBL: X55787;
DR UniProtKB: P27577;
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RN [1]; RE0035772.
RX PUBMED: 11782450.
RA Seidel J. J., Graves B. J.
RT An ERK2 docking site in the Pointed domain distinguishes a subset of ETS transcription factors.
RL Genes Dev. 16:127-137 (2002).
RN [2]; RE0048000.
RX PUBMED: 12907668.
RA McCarthy K. M., McDevit D., Andreucci A., Reeves R., Nikolajczyk B. S.
RT HMGA1 co-activates transcription in B cells through indirect association with DNA.
RL J. Biol. Chem. 278:42106-42114 (2003).
RN [3]; RE0048332.
RX PUBMED: 16729975.
RA Nishida T., Terashima M., Fukami K.
RT PIASy-mediated repression of the Ets-1 is independent of its sumoylation.
RL Biochem. Biophys. Res. Commun. 345:1536-1546 (2006).
RN [4]; RE0048566.
RX PUBMED: 15572696.
RA Foulds C. E., Nelson M. L., Blaszczak A. G., Graves B. J.
RT Ras/mitogen-activated protein kinase signaling activates Ets-1 and Ets-2 by CBP/p300 recruitment.
RL Mol. Cell. Biol. 24:10954-10964 (2004).
RN [5]; RE0048567.
RX PUBMED: 10673508.
RA Cowley D. O., Graves B. J.
RT Phosphorylation represses Ets-1 DNA binding by reinforcing autoinhibition.
RL Genes Dev. 14:366-376 (2000).
RN [6]; RE0048590.
RX PUBMED: 16319071.
RA Macauley M. S., Errington W. J., Scharpf M., Mackereth C. D., Blaszczak A. G., Graves B. J., McIntosh L. P.
RT Beads-on-a-string, characterization of ETS-1 sumoylated within its flexible N-terminal sequence.
RL J. Biol. Chem. 281:4164-4172 (2006).
RN [7]; RE0063974.
RX PUBMED: 15994560.
RA Pufall M. A., Lee G. M., Nelson M. L., Kang H. S., Velyvis A., Kay L. E., McIntosh L. P., Graves B. J.
RT Variable control of Ets-1 DNA binding by multiple phosphates in an unstructured region.
RL Science 309:142-145 (2005).
RN [8]; RE0002584.
RX PUBMED: 1409581.
RA Hagman J., Grosschedl R.
RT An inhibitory carboxyl-terminal domain in Ets-1 and Ets-2 mediates differential binding of Ets family factors to promoter sequences of the mb-1 gene
RL Proc. Natl. Acad. Sci. USA 89:8889-8893 (1992).
RN [9]; RE0005316.
RX PUBMED: 8223245.
RA Klaembt C.
RT The Drosophila gene pointed encodes two ETS-like proteins which are involved in the development of the midline glial cells
RL Development 117:163-176 (1993).
RN [10]; RE0023824.
RX PUBMED: 11779502.
RA Garvie C. W., Hagman J., Wolberger C.
RT Structural studies of Ets-1/Pax5 complex formation on DNA.
RL Mol. Cell 8:1267-1276 (2001).
RN [11]; RE0016625.
RX PUBMED: 7774816.
RA Giese K., Kingsley C., Kirshner J. R., Grosschedl R.
RT Assembly and function of a TCR alpha enhancer complex id dependent on LEF-1-induced DNA bending and multiple protein-protein interactions.
RL Genes Dev. 9:995-1008 (1995).
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