TRANSFAC FACTOR TABLE, Release 2017.2 - public - 2017-06-30, (C) QIAGEN

AC T08420 XX ID T08420 XX DT 18.01.2006 (created); anu. DT 15.12.2014 (updated); ros. CO Copyright (C), QIAGEN. XX FA c-Ets-1 XX SY c-Ets-1; Ets1; p54. XX OS mouse, Mus musculus OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae XX GE G006040 Ets1. XX CL C0016; ETS; XX SZ 440 AA; 50.2 kDa (cDNA) (calc.), 66 kDa (SDS) XX SQ MKAAVDLKPTLTIIKTEKVDLELFPSPDMECADVPLLTPSSKEMMSQALKATFSGFTKEQ SQ QRLGIPKDPRQWTETHVRDWVMWAVNEFSLKGVDFQKFCMSGAALCALGKECFLELAPDF SQ VGDILWEHLEILQKEDVKPYQVNGANPTYPESCYTSDYFISYGIEHAQCVPPSEFSEPSF SQ ITESYQTLHPISSEELLSLKYENDYPSVILQDPLQTDTLQTDYFAIKQEVLTPDNMCLGR SQ ASRGKLGGQDSFESVESYDSCDRLTQSWSSQSSFNSLQRVPSYDSFDYEDYPAALPNHKP SQ KGTFKDYVRDRADLNKDKPVIPAAALAGYTGSGPIQLWQFLLELLTDKSCQSFISWTGDG SQ WEFKLSDPDEVARRWGKRKNKPKMNYEKLSRGLRYYYDKNIIHKTAGKRYVYRFVCDLQS SQ LLGYTPEELHAMLDVKPDAD XX SC translated from EMBL:BC010588 XX FT 53 136 PF02198; Sterile alpha motif (SAM)/Pointed domain. FT 53 136 SM00251; SAM2_3. FT 54 132 PNT domain (POINTED) [1]. FT 68 134 POINTED domain of homology [9]. FT 114 120 LXLXXXF motif of PNT domain involved in ERK2 docking. [1]. FT 123 240 interaction with murine PEBP2alphaA1 [11]. FT 334 417 PF00178; Ets-domain. FT 334 419 SM00413; etsneu2. FT 335 415 PS50061; ETS_DOMAIN_3. FT 337 405 PS50140; HSF_ETS. FT 388 395 essential DNA contacts [10]. FT 398 399 interaction with Pax-5 [10]. FT 423 440 repression of DNA-binding [8]. XX IN T08499 CBP; mouse, Mus musculus. IN T10639 HMGIY; Mammalia. XX MX M00032 V$CETS1P54_01. MX M00074 V$CETS1P54_02. MX M01078 V$CETS1P54_03. MX M01986 V$CETS1_01. MX M01870 V$CETS1_Q6. MX M00339 V$ETS1_B. MX M08881 V$ETSLIKE_Q4. MX M00340 V$ETS_B. MX M00771 V$ETS_Q4. MX M00971 V$ETS_Q6. XX BS R33798. BS R02153. BS R17177. BS R04450. BS R26370. BS R26371. BS R26372. BS R26373. BS R26374. BS R26375. BS R33546. BS R60656. BS R60657. BS R60658. BS R60660. BS R19142. BS R19143. BS R56498. BS R18140. BS R18141. BS R18142. BS R01155. BS R01156. BS R39545. BS R39546. BS R39551. XX DR TRANSPATH: MO000057516. DR EMBL: BC010588; DR EMBL: M58482; DR EMBL: X53953; DR EMBL: X55787; DR UniProtKB: P27577; XX RN [1]; RE0035772. RX PUBMED: 11782450. RA Seidel J. J., Graves B. J. RT An ERK2 docking site in the Pointed domain distinguishes a subset of ETS transcription factors. RL Genes Dev. 16:127-137 (2002). RN [2]; RE0048000. RX PUBMED: 12907668. RA McCarthy K. M., McDevit D., Andreucci A., Reeves R., Nikolajczyk B. S. RT HMGA1 co-activates transcription in B cells through indirect association with DNA. RL J. Biol. Chem. 278:42106-42114 (2003). RN [3]; RE0048332. RX PUBMED: 16729975. RA Nishida T., Terashima M., Fukami K. RT PIASy-mediated repression of the Ets-1 is independent of its sumoylation. RL Biochem. Biophys. Res. Commun. 345:1536-1546 (2006). RN [4]; RE0048566. RX PUBMED: 15572696. RA Foulds C. E., Nelson M. L., Blaszczak A. G., Graves B. J. RT Ras/mitogen-activated protein kinase signaling activates Ets-1 and Ets-2 by CBP/p300 recruitment. RL Mol. Cell. Biol. 24:10954-10964 (2004). RN [5]; RE0048567. RX PUBMED: 10673508. RA Cowley D. O., Graves B. J. RT Phosphorylation represses Ets-1 DNA binding by reinforcing autoinhibition. RL Genes Dev. 14:366-376 (2000). RN [6]; RE0048590. RX PUBMED: 16319071. RA Macauley M. S., Errington W. J., Scharpf M., Mackereth C. D., Blaszczak A. G., Graves B. J., McIntosh L. P. RT Beads-on-a-string, characterization of ETS-1 sumoylated within its flexible N-terminal sequence. RL J. Biol. Chem. 281:4164-4172 (2006). RN [7]; RE0063974. RX PUBMED: 15994560. RA Pufall M. A., Lee G. M., Nelson M. L., Kang H. S., Velyvis A., Kay L. E., McIntosh L. P., Graves B. J. RT Variable control of Ets-1 DNA binding by multiple phosphates in an unstructured region. RL Science 309:142-145 (2005). RN [8]; RE0002584. RX PUBMED: 1409581. RA Hagman J., Grosschedl R. RT An inhibitory carboxyl-terminal domain in Ets-1 and Ets-2 mediates differential binding of Ets family factors to promoter sequences of the mb-1 gene RL Proc. Natl. Acad. Sci. USA 89:8889-8893 (1992). RN [9]; RE0005316. RX PUBMED: 8223245. RA Klaembt C. RT The Drosophila gene pointed encodes two ETS-like proteins which are involved in the development of the midline glial cells RL Development 117:163-176 (1993). RN [10]; RE0023824. RX PUBMED: 11779502. RA Garvie C. W., Hagman J., Wolberger C. RT Structural studies of Ets-1/Pax5 complex formation on DNA. RL Mol. Cell 8:1267-1276 (2001). RN [11]; RE0016625. RX PUBMED: 7774816. RA Giese K., Kingsley C., Kirshner J. R., Grosschedl R. RT Assembly and function of a TCR alpha enhancer complex id dependent on LEF-1-induced DNA bending and multiple protein-protein interactions. RL Genes Dev. 9:995-1008 (1995). XX //