AC T08445
XX
ID T08445
XX
DT 20.01.2006 (created); jag.
DT 16.05.2014 (updated); ili.
CO Copyright (C), QIAGEN.
XX
FA Elk1-isoform1
XX
SY Elk-1; Elk1-1; p62TCF; TCF-A.
XX
OS human, Homo sapiens
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; primates
XX
GE G003924 ELK1; HGNC: Elk1.
XX
CL C0016; ETS; 3.5.2.2.1.1.
XX
SZ 428 AA; 44.9 kDa (gene) (calc.), 58 kDa (SDS) [13]
XX
SQ MDPSVTLWQFLLQLLREQGNGHIISWTSRDGGEFKLVDAEEVARLWGLRKNKTNMNYDKL
SQ SRALRYYYDKNIIRKVSGQKFVYKFVSYPEVAGCSTEDCPPQPEVSVTSTMPNVAPAAIH
SQ AAPGDTVSGKPGTPKGAGMAGPGGLARSSRNEYMRSGLYSTFTIQSLQPQPPPHPRPAVV
SQ LPNAAPAGAAAPPSGSRSTSPSPLEACLEAEEAGLPLQVILTPPEAPNLKSEELNVEPGL
SQ GRALPPEVKVEGPKEELEVAGERGFVPETTKAEPEVPPQEGVPARLPAVVMDTAGQAGGH
SQ AASSPEISQPQKGRKPRDLELPLSPSLLGGPGPERTPGSGSGSGLQAPGPALTPSLLPTH
SQ TLTPVLLTPSSLPPSIHFWSTLSPIAPRSPAKLSFQFPSSGSAQVHIPSISVDGLSTPVV
SQ LSPGPQKP
XX
SC translated from EMBL:M25269
XX
FT 1 88 
interactions with C/EBPbeta [10].
FT 4 88 
PF00178; Ets-domain.
FT 4 90 
SM00413; etsneu2.
FT 5 86 
PS50061; ETS_DOMAIN_3.
FT 7 76 
PS50140; HSF_ETS.
FT 137 169 
essential for ternary complex formation with SRF [11].
FT 137 169 
essential for ternary complex formation with SRF [8].
FT 148 168 
Box B, interactions with SRF [6].
FT 148 168 
Box B, interactions with SRF [11].
FT 307 428 
regulated trans-activation domain [9].
FT 307 428 regulated trans-activation domain [12].
FT 324 324 serine-phosphorylation by MAP kinase(-like) activity (ERK1, ERK2) [7].
FT 336 336 threonine-phosphorylation by MAP kinase(-like) activity (ERK1, ERK2) [7].
FT 383 383 serine-phosphorylation by MAP kinase(-like) activity (ERK1, ERK2) [7].
FT 389 389 serine-phosphorylation by MAP kinase(-like) activity (ERK1, ERK2) [7].
FT 422 422 serine-phosphorylation by MAP kinase(-like) activity (ERK1, ERK2) [7].
XX
IN T08487 AR-isoform1; human, Homo sapiens.
IN T08499 CBP; mouse, Mus musculus.
IN T21852 HDAC1; Mammalia.
XX
MX M00007 V$ELK1_01.
MX M00025 V$ELK1_02.
MX M02059 V$ELK1_06.
MX M07252 V$ELK1_Q4.
MX M03819 V$ELK1_Q6.
MX M00771 V$ETS_Q4.
MX M00971 V$ETS_Q6.
XX
BS R00040.
BS R14965.
BS R00460.
BS R00466.
BS R15110.
BS R15111.
BS R14623.
BS R14624.
BS R14625.
BS R16113.
BS R15105.
BS R01155.
XX
DR TRANSPATH: MO000057927.
DR EMBL: M25269; HSELK1A.
DR UniProtKB: P19419-1;
XX
RN [1]; RE0028344.
RX PUBMED: 11083868.
RA Nissen L. J., Gelly J. C., Hipskind R. A.
RT Induction-independent recruitment of CREB-binding protein to the c-fos serum response element through interactions between the bromodomain and Elk-1.
RL J. Biol. Chem. 276:5213-21 (2001).
RN [2]; RE0047963.
RX PUBMED: 11134340.
RA Roberts E. C., Deed R. W., Inoue T., Norton J. D., Sharrocks A. D.
RT Id helix-loop-helix proteins antagonize pax transcription factor activity by inhibiting DNA binding.
RL Mol. Cell. Biol. 21:524-533 (2001).
RN [3]; RE0048074.
RX PUBMED: 11283259.
RA Yang S. H., Vickers E., Brehm A., Kouzarides T., Sharrocks A. D.
RT Temporal recruitment of the mSin3A-histone deacetylase corepressor complex to the ETS domain transcription factor Elk-1.
RL Mol. Cell. Biol. 21:2802-2814 (2001).
RN [4]; RE0048801.
RX PUBMED: 15210726.
RA Salinas S., Briancon-Marjollet A., Bossis G., Lopez M. A., Piechaczyk M., Jariel-Encontre I., Debant A., Hipskind R. A.
RT SUMOylation regulates nucleo-cytoplasmic shuttling of Elk-1.
RL J. Cell Biol. 165:767-773 (2004).
RN [5]; RE0065087.
RX PUBMED: 17652082.
RA Patel D. N., King C. A., Bailey S. R., Holt J. W., Venkatachalam K., Agrawal A., Valente A. J., Chandrasekar B.
RT Interleukin-17 stimulates C-reactive protein expression in hepatocytes and smooth muscle cells via p38 MAPK and ERK1/2-dependent NF-kappaB and C/EBPbeta activation.
RL J. Biol. Chem. 282:27229-27238 (2007).
RN [6]; RE0015343.
RX PUBMED: 9171356.
RA Ling Y., Lakey J. H., Roberts C. E., Sharrocks A.D.
RT Molecular characterization of the B-box protein-protein interaction motif of the ETS-domain transcription factor Elk-1
RL EMBO J. 16:2431-2440 (1997).
RN [7]; RE0005333.
RX PUBMED: 7889942.
RA Gille H., Kortenjann M., Thomae O., Moomaw C., Slaughter C., Cobb M. H., Shaw P. E.
RT ERK phosphorylation potentiates Elk-1-mediated ternary complex formation and transactivation
RL EMBO J. 14:951-962 (1995).
RN [8]; RE0005372.
RX PUBMED: 1630903.
RA Janknecht R., Nordheim A.
RT Elk-1 protein domains required for direct and SRF-assisted DNA-binding
RL Nucleic Acids Res. 20:3317-3324 (1992).
RN [9]; RE0000280.
RX PUBMED: 8386592.
RA Marais R., Wynne J., Treisman R.
RT The SRF accessory protein Elk-1 contains a growth factor-regulated transcriptional activation domain
RL Cell 73:381-393 (1993).
RN [10]; RE0016725.
RX PUBMED: 11151091.
RA Hanlon M., Bundy L. M., Sealy L.
RT C/EBPBeta and Elk-1 synergistically transactivate the c-fos serum response element.
RL BMC Cell Biol. 1:2 (2000).
RN [11]; RE0005331.
RX PUBMED: 8164681.
RA Shore P., Sharrocks A. D.
RT The transcriptional factors Elk-1 and serum response factor interact by direct protein-protein contacts mediated by a short region of Elk-1
RL Mol. Cell. Biol. 14:3283-3291 (1994).
RN [12]; RE0005335.
RX PUBMED: 8477450.
RA Hill C. S., Marais R., John S., Wynne J., Dalton S., Treisman R.
RT Functional analysis of a growth factor-responsive transcription factor complex
RL Cell 73:395-406 (1993).
RN [13]; RE0005334.
RX PUBMED: 2539641.
RA Rao V. N., Huebner K., Isobe M., Ar-rushdi A., Croce C. M., Reddy E. S.
RT elk, tissue-specific ets-related genes on chromosomes X and 14 near translocation breakpoints
RL Science 244:66-70 (1989).
XX
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