AC T30703
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ID T30703
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DT 12.03.2005 (created); nvo.
DT 09.10.2014 (updated); yre.
CO Copyright (C), QIAGEN.
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FA SIRT1
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SY silent information regulator type 1; SIR2-like protein 1; SIR2alpha; SIR2L1; SIRT1; sirtuin type 1; yeast silent information regulator 2 (Sir2p) homolog.
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OS Mammalia
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia
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IN T10346 c-Fos; Mammalia.
IN T09446 c-Jun; Mammalia.
IN T08499 CBP; mouse, Mus musculus.
IN T05868 Clock; mouse, Mus musculus.
IN T25729 Dnmt1-isoform1; human, Homo sapiens.
IN T14067 FOXO1A; Mammalia.
IN T10677 FOXO3a; Mammalia.
IN T15124 FOXP3; mouse, Mus musculus.
IN T06375 ING1b; human, Homo sapiens.
IN T25923 ING1c; human, Homo sapiens.
IN T14816 IRF-1; Mammalia.
IN T18466 IRF-7; Mammalia.
IN T27204 MOF-isoform1; human, Homo sapiens.
IN T00593 NF-kappaB1-p50; human, Homo sapiens.
IN T15350 PARP; Mammalia.
IN T08711 RelA-p65; human, Homo sapiens.
IN T31896 VDR; Mammalia.
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BS R62474.
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DR TRANSPATH: MO000048476.
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RN [1]; RE0025520.
RX PUBMED: 14976264.
RA Brunet A., Sweeney L. B., Sturgill J. F., Chua K. F., Greer P. L., Lin Y., Tran H., Ross S. E., Mostoslavsky R., Cohen H. Y., Hu L. S., Cheng H. L., Jedrychowski M. P., Gygi S. P., Sinclair D. A., Alt F. W., Greenberg M. E.
RT Stress-dependent regulation of FOXO transcription factors by the SIRT1 deacetylase.
RL Science 303:2011-2015 (2004).
RN [2]; RE0033107.
RX PUBMED: 15126506.
RA van der Horst A., Tertoolen L. G., de Vries-Smits L. M., Frye R. A., Medema R. H., Burgering B. M.
RT FOXO4 is acetylated upon peroxide stress and deacetylated by the longevity protein hSir2(SIRT1).
RL J. Biol. Chem. 279:28873-9 (2004).
RN [3]; RE0033289.
RX PUBMED: 15220471.
RA Daitoku H., Hatta M., Matsuzaki H., Aratani S., Ohshima T., Miyagishi M., Nakajima T., Fukamizu A.
RT Silent information regulator 2 potentiates Foxo1-mediated transcription through its deacetylase activity.
RL Proc. Natl. Acad. Sci. USA 101:10042-7 (2004).
RN [4]; RE0044506.
RX PUBMED: 12930829.
RA Senawong T., Peterson V. J., Avram D., Shepherd D. M., Frye R. A., Minucci S., Leid M.
RT Involvement of the histone deacetylase SIRT1 in chicken ovalbumin upstream promoter transcription factor (COUP-TF)-interacting protein 2-mediated transcriptional repression
RL J. Biol. Chem. 278:43041-50 (2003).
RN [5]; RE0044698.
RX PUBMED: 15310905.
RA Araki T., Sasaki Y., Milbrandt J.
RT Increased nuclear NAD biosynthesis and SIRT1 activation prevent axonal degeneration
RL Science 305:1010-3 (2004).
RN [6]; RE0052155.
RX PUBMED: 15152190.
RA Yeung F., Hoberg J. E., Ramsey C. S., Keller M. D., Jones D. R., Frye R. A., Mayo M. W.
RT Modulation of NF-kappaB-dependent transcription and cell survival by the SIRT1 deacetylase.
RL EMBO J. 23:2369-2380 (2004).
RN [7]; RE0055189.
RX PUBMED: 15469825.
RA Vaquero A., Scher M., Lee D., Erdjument-Bromage H., Tempst P., Reinberg D.
RT Human SirT1 interacts with histone H1 and promotes formation of facultative heterochromatin.
RL Mol. Cell 16:93-105 (2004).
RN [8]; RE0064434.
RX PUBMED: 18193082.
RA Binda O., Nassif C., Branton P. E.
RT SIRT1 negatively regulates HDAC1-dependent transcriptional repression by the RBP1 family of proteins.
RL Oncogene 27:3384-3392 (2008).
RN [9]; RE0066089.
RX PUBMED: 20042607.
RA Zhang R., Chen H. Z., Liu J. J., Jia Y. Y., Zhang Z. Q., Yang R. F., Zhang Y., Xu J., Wei Y. S., Liu D. P., Liang C. C.
RT SIRT1 Suppresses Activator Protein-1 Transcriptional Activity and Cyclooxygenase-2 Expression in Macrophages.
RL J. Biol. Chem. 285:7097-7110 (2010).
RN [10]; RE0069450.
RX PUBMED: 21245319.
RA Liu X., Wang D., Zhao Y., Tu B., Zheng Z., Wang L., Wang H., Gu W., Roeder R. G., Zhu W. G.
RT Methyltransferase Set7/9 regulates p53 activity by interacting with Sirtuin 1 (SIRT1).
RL Proc. Natl. Acad. Sci. USA 108:1925-1930 (2011).
RN [11]; RE0070207.
RX PUBMED: 20733005.
RA An B. S., Tavera-Mendoza L. E., Dimitrov V., Wang X., Calderon M. R., Wang H. J., White J. H.
RT Stimulation of Sirt1-regulated FoxO protein function by the ligand-bound vitamin D receptor.
RL Mol. Cell. Biol. 30:4890-4900 (2010).
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