AC T10677
XX
ID T10677
XX
DT 10.03.2005 (created); nvo.
DT 06.01.2016 (updated); ros.
CO Copyright (C), QIAGEN.
XX
FA FOXO3a
XX
SY AF6q21; DKFZp781A0677; FKHRL1; FKHRL1P2; forkhead box O3; forkhead box O3A; Forkhead box protein O3A; FOXO2; Foxo3; FOXO3A; MGC12739; MGC31925.
XX
OS Mammalia
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia
XX
IN T02245 AML1b; human, Homo sapiens.
IN T09248 AML2-isoform1; human, Homo sapiens.
IN T23092 BF-1; Mammalia.
IN T09637 ER-alpha; Mammalia.
IN T14713 FOXK1; mouse, Mus musculus.
IN T05252 HDAC5; human, Homo sapiens.
IN T17874 LXR-alpha; Mammalia.
IN T23091 p300; Mammalia.
IN T30703 SIRT1; Mammalia.
IN T31896 VDR; Mammalia.
XX
MX M01137 V$FOXO3A_Q1.
MX M07287 V$FOXO3A_Q3.
MX M00477 V$FOXO3_01.
XX
BS R09923.
BS R63920.
BS R63924.
BS R68748.
BS R64742.
BS R33291.
BS R66301.
BS R67306.
BS R67307.
BS R67308.
BS R67310.
BS R67621.
BS R69968.
BS R69970.
BS R57641.
BS R57642.
BS R63273.
BS R61315.
BS R61316.
BS R31039.
BS R69334.
BS R38380.
BS R26469.
BS R21731.
BS R40962.
BS R40963.
BS R40667.
BS R68754.
BS R68755.
BS R67526.
BS R26389.
BS R26390.
BS R26391.
BS R26392.
BS R57827.
BS R68750.
BS R68751.
BS R68753.
BS R68728.
BS R68731.
BS R68749.
BS R67626.
BS R26393.
BS R26394.
BS R21732.
BS R21733.
XX
DR TRANSPATH: MO000046456.
XX
RN [1]; RE0021455.
RX PUBMED: 11154281.
RA Brunet A., Park J., Tran H., Hu L. S., Hemmings B. A., Greenberg M. E.
RT Protein kinase SGK mediates survival signals by phosphorylating the forkhead transcription factor FKHRL1 (FOXO3a)
RL Mol. Cell. Biol. 21:952-965 (2001).
RN [2]; RE0025520.
RX PUBMED: 14976264.
RA Brunet A., Sweeney L. B., Sturgill J. F., Chua K. F., Greer P. L., Lin Y., Tran H., Ross S. E., Mostoslavsky R., Cohen H. Y., Hu L. S., Cheng H. L., Jedrychowski M. P., Gygi S. P., Sinclair D. A., Alt F. W., Greenberg M. E.
RT Stress-dependent regulation of FOXO transcription factors by the SIRT1 deacetylase.
RL Science 303:2011-2015 (2004).
RN [3]; RE0032152.
RX PUBMED: 11313458.
RA Yu J. T., Foster R. G., Dean D. C.
RT Transcriptional repression by RB-E2F and regulation of anchorage-independent survival.
RL Mol. Cell. Biol. 21:3325-35 (2001).
RN [4]; RE0032615.
RX PUBMED: 15084260.
RA Hu M. C., Lee D. F., Xia W., Golfman L. S., Ou-Yang F., Yang J. Y., Zou Y., Bao S., Hanada N., Saso H., Kobayashi R., Hung M. C.
RT IkappaB kinase promotes tumorigenesis through inhibition of forkhead FOXO3a.
RL Cell 117:225-37 (2004).
RN [5]; RE0033113.
RX PUBMED: 12239572.
RA Kops G. J., Dansen T. B., Polderman P. E., Saarloos I., Wirtz K. W., Coffer P. J., Huang T. T., Bos J. L., Medema R. H., Burgering B. M.
RT Forkhead transcription factor FOXO3a protects quiescent cells from oxidative stress.
RL Nature 419:316-21 (2002).
RN [6]; RE0033115.
RX PUBMED: 15047604.
RA Kwon H. S., Huang B., Unterman T. G., Harris R. A.
RT Protein kinase B-alpha inhibits human pyruvate dehydrogenase kinase-4 gene induction by dexamethasone through inactivation of FOXO transcription factors.
RL Diabetes 53:899-910 (2004).
RN [7]; RE0035323.
RX PUBMED: 15031210.
RA Asselin-Labat M.-L., David M., Biola-Vidamment A., Lecoeuche D., Zennaro M.-C., Bertoglio J., Pallardy M.
RT GILZ, a new target for the transcription factor FoxO3, protects T lymphocytes from interleukin-2 withdrawal-induced apoptosis.
RL Blood 104:215-223 (2004).
RN [8]; RE0037900.
RX PUBMED: 12456669.
RA Komatsu N., Watanabe T., Uchida M., Mori M., Kirito K., Kikuchi S., Liu Q., Tauchi T., Miyazawa K., Endo H., Nagai T., Ozawa K.
RT A member of Forkhead transcription factor FKHRL1 is a downstream effector of STI571-induced cell cycle arrest in BCR-ABL-expressing cells
RL J. Biol. Chem. 278:6411-9 (2003).
RN [9]; RE0038573.
RX PUBMED: 12970676.
RA Leisser C., Rosenberger G., Maier S., Fuhrmann G., Grusch M., Strasser S., Huettenbrenner S., Fassl S., Polgar D., Krieger S., Cerni C., Hofer-Warbinek R., deMartin R., Krupitza G.
RT Subcellular localisation of Cdc25A determines cell fate
RL Cell Death Differ. 11:80-9 (2004).
RN [10]; RE0041849.
RX PUBMED: 14734530.
RA Bakker W. J., Blazquez-Domingo M., Kolbus A., Besooyen J., Steinlein P., Beug H., Coffer P. J., Lowenberg B., von Lindern M., van Dijk T. B.
RT FoxO3a regulates erythroid differentiation and induces BTG1, an activator of protein arginine methyl transferase 1
RL J. Cell Biol. 164:175-84 (2004).
RN [11]; RE0041850.
RX PUBMED: 14563822.
RA Dansen T. B., Kops G. J., Denis S., Jelluma N., Wanders R. J., Bos J. L., Burgering B. M., Wirtz K. W.
RT Regulation of sterol carrier protein gene expression by the forkhead transcription factor FOXO3a
RL J. Lipid Res. 45:81-8 (2004).
RN [12]; RE0046099.
RX PUBMED: 15109499.
RA Sandri M., Sandri C., Gilbert A., Skurk C., Calabria E., Picard A., Walsh K., Schiaffino S., Lecker S. H., Goldberg A. L.
RT Foxo transcription factors induce the atrophy-related ubiquitin ligase atrogin-1 and cause skeletal muscle atrophy
RL Cell 117:399-412 (2004).
RN [13]; RE0048307.
RX PUBMED: 16373335.
RA Yamamura Y., Lee W. L., Inoue K., Ida H., Ito Y.
RT RUNX3 cooperates with FoxO3a to induce apoptosis in gastric cancer cells.
RL J. Biol. Chem. 281:5267-5276 (2006).
RN [14]; RE0051245.
RX PUBMED: 17965779.
RA Li H. H., Willis M. S., Lockyer P., Miller N., McDonough H., Glass D. J., Patterson C.
RT Atrogin-1 inhibits Akt-dependent cardiac hypertrophy in mice via ubiquitin-dependent coactivation of Forkhead proteins.
RL J. Clin. Invest. 117:3211-3223 (2007).
RN [15]; RE0051310.
RX PUBMED: 16354658.
RA Albers M., Blume B., Schlueter T., Wright M. B., Kober I., Kremoser C., Deuschle U., Koegl M.
RT A novel principle for partial agonism of liver X receptor ligands. Competitive recruitment of activators and repressors.
RL J. Biol. Chem. 281:4920-4930 (2006).
RN [16]; RE0051909.
RX PUBMED: 18204439.
RA Yang J. Y., Zong C. S., Xia W., Yamaguchi H., Ding Q., Xie X., Lang J. Y., Lai C. C., Chang C. J., Huang W. C., Huang H., Kuo H. P., Lee D. F., Li L. Y., Lien H. C., Cheng X., Chang K. J., Hsiao C. D., Tsai F. J., Tsai C. H., Sahin A. A., Muller W. J., Mills G. B., Yu D., Hortobagyi G. N., Hung M. C.
RT ERK promotes tumorigenesis by inhibiting FOXO3a via MDM2-mediated degradation.
RL Nat. Cell Biol. 10:138-148 (2008).
RN [17]; RE0054983.
RX PUBMED: 18794148.
RA Brenkman A. B., de Keizer P. L., van den Broek N. J., van der Groep P., van Diest P. J., van der Horst A., Smits A. M., Burgering B. M.
RT The peptidyl-isomerase Pin1 regulates p27kip1 expression through inhibition of Forkhead box O tumor suppressors.
RL Cancer Res. 68:7597-7605 (2008).
RN [18]; RE0055951.
RX PUBMED: 17726016.
RA Jang S. W., Yang S. J., Srinivasan S., Ye K.
RT Akt phosphorylates MstI and prevents its proteolytic activation, blocking FOXO3 phosphorylation and nuclear translocation.
RL J. Biol. Chem. 282:30836-30844 (2007).
RN [19]; RE0065073.
RX PUBMED: 19056725.
RA Park S., Guo J., Kim D., Cheng J. Q.
RT Identification of 24p3 as a direct target of Foxo3a regulated by interleukin-3 through the phosphoinositide 3-kinase/Akt pathway.
RL J. Biol. Chem. 284:2187-2193 (2009).
RN [20]; RE0066275.
RX PUBMED: 20028971.
RA Bi W., Xiao L., Jia Y., Wu J., Xie Q., Ren J., Ji G., Yuan Z.
RT c-Jun N-terminal kinase enhances MST1-mediated pro-apoptotic signaling through phosphorylation at serine 82.
RL J. Biol. Chem. 285:6259-6264 (2010).
RN [21]; RE0067981.
RX PUBMED: 18678662.
RA Snoeks L., Weber C. R., Turner J. R., Bhattacharyya M., Wasland K., Savkovic S. D.
RT Tumor suppressor Foxo3a is involved in the regulation of lipopolysaccharide-induced interleukin-8 in intestinal HT-29 cells.
RL Infect. Immun. 76:4677-4685 (2008).
RN [22]; RE0069409.
RX PUBMED: 18344987.
RA Tsai W. B., Chung Y. M., Takahashi Y., Xu Z., Hu M. C.
RT Functional interaction between FOXO3a and ATM regulates DNA damage response.
RL Nat. Cell Biol. 10:460-467 (2008).
RN [23]; RE0070207.
RX PUBMED: 20733005.
RA An B. S., Tavera-Mendoza L. E., Dimitrov V., Wang X., Calderon M. R., Wang H. J., White J. H.
RT Stimulation of Sirt1-regulated FoxO protein function by the ligand-bound vitamin D receptor.
RL Mol. Cell. Biol. 30:4890-4900 (2010).
RN [24]; RE0070735.
RX PUBMED: 20110348.
RA Singh A., Ye M., Bucur O., Zhu S., Tanya Santos M., Rabinovitz I., Wei W., Gao D., Hahn W. C., Khosravi-Far R.
RT Protein phosphatase 2A reactivates FOXO3a through a dynamic interplay with 14-3-3 and AKT.
RL Mol. Biol. Cell 21:1140-1152 (2010).
XX
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