AC T15124
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ID T15124
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DT 08.09.2008 (created); tgo.
DT 02.09.2014 (updated); spk.
CO Copyright (C), QIAGEN.
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FA FOXP3
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SY scurfin (gene); SFN.
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OS mouse, Mus musculus
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae
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GE G006103 Foxp3.
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CL C0023; fork head; 3.3.1.16.3.1.
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SZ 429 AA; 47.3 kDa (cDNA) (calc.).
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SQ MPNPRPAKPMAPSLALGPSPGVLPSWKTAPKGSELLGTRGSGGPFQGRDLRSGAHTSSSL
SQ NPLPPSQLQLPTVPLVMVAPSGARLGPSPHLQALLQDRPHFMHQLSTVDAHAQTPVLQVR
SQ PLDNPAMISLPPPSAATGVFSLKARPGLPPGINVASLEWVSREPALLCTFPRSGTPRKDS
SQ NLLAAPQGSYPLLANGVCKWPGCEKVFEEPEEFLKHCQADHLLDEKGKAQCLLQREVVQS
SQ LEQQLELEKEKLGAMQAHLAGKMALAKAPSVASMDKSSCCIVATSTQGSVLPAWSAPREA
SQ PDGGLFAVRRHLWGSHGNSSFPEFFHNMDYFKYHNMRPPFTYATLIRWAILEAPERQRTL
SQ NEIYHWFTRMFAYFRNHPATWKNAIRHNLSLHKCFVRVESEKGAVWTVDEFEFRKKRSQR
SQ PNKCSNPCP
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SC translateded from EMBL #AF277991
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FT 46 409 
PF00478; IMP dehydrogenase / GMP reductase domain.
FT 198 221 
C2H2 zinc finger domain [1].
FT 335 417 
SM00339; forkneu4.
FT 337 420 
fork head domain [1].
FT 337 420 
PF00250; Fork head domain.
FT 337 423 
PS50039; FORK_HEAD_3.
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IN T10351 RORgamma; mouse, Mus musculus.
IN T30703 SIRT1; Mammalia.
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MX M01599 V$FOXP3_01.
MX M00992 V$FOXP3_Q4.
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DR TRANSPATH: MO000137560.
DR EMBL: AF277991;
DR EMBL: AF277994;
DR UniProtKB: Q99JB6;
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RN [1]; RE0015693.
RX PUBMED: 11138001.
RA Brunkow M. E., Jeffery E. W., Hjerrild K. A., Paeper B., Clark L. B., Yasayko S. A., Wilkinson J. E., Galas D., Ziegler S. F., Ramsdell F.
RT Disruption of a new forkhead/winged-helix protein, scurfin, results in the fatal lymphoproliferative disorder of the scurfy mouse.
RL Nat. Genet. 27:68-73 (2001).
RN [2]; RE0015696.
RX PUBMED: 10072494.
RA Clark L. B., Appleby M. W., Brunkow M. E., Wilkinson J. E., Ziegler S. F., Ramsdell F.
RT Cellular and molecular characterization of the scurfy mouse mutant
RL J. Immunol. 162:2546-2554 (1999).
RN [3]; RE0065711.
RX PUBMED: 18368049.
RA Zhou L., Lopes J. E., Chong M. M., Ivanov I. I., Min R., Victora G. D., Shen Y., Du J., Rubtsov Y. P., Rudensky A. Y., Ziegler S. F., Littman D. R.
RT TGF-beta-induced Foxp3 inhibits T(H)17 cell differentiation by antagonizing RORgammat function.
RL Nature 453:236-240 (2008).
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