AC T25729
XX
ID T25729
XX
DT 21.08.2006 (created); ran.
DT 30.12.2014 (updated); ros.
CO Copyright (C), QIAGEN.
XX
FA Dnmt1-isoform1
XX
SY CXXC9; DNA (cytosine-5)-methyltransferase 1; DNA methyltransferase (cytosine-5) 1; DNA methyltransferase HsaI; DNA MTase HsaI; DNMT; DNMT1; Dnmt1o; M.HsaI; MCMT; Met-1; Met1; MTase.
XX
OS human, Homo sapiens
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; primates
XX
GE G018186 DNMT1; HGNC: DNMT1.
XX
CL C0070; CXXC; 2.6.1.0.6.1.
XX
SZ 1616 AA; 183.2 kDa (calc.).
XX
SQ MPARTAPARVPTLAVPAISLPDDVRRRLKDLERDSLTEKECVKEKLNLLHEFLQTEIKNQ
SQ LCDLETKLRKEELSEEGYLAKVKSLLNKDLSLENGAHAYNREVNGRLENGNQARSEARRV
SQ GMADANSPPKPLSKPRTPRRSKSDGEAKPEPSPSPRITRKSTRQTTITSHFAKGPAKRKP
SQ QEESERAKSDESIKEEDKDQDEKRRRVTSRERVARPLPAEEPERAKSGTRTEKEEERDEK
SQ EEKRLRSQTKEPTPKQKLKEEPDREARAGVQADEDEDGDEKDEKKHRSQPKDLAAKRRPE
SQ EKEPEKVNPQISDEKDEDEKEEKRRKTTPKEPTEKKMARAKTVMNSKTHPPKCIQCGQYL
SQ DDPDLKYGQHPPDAVDEPQMLTNEKLSIFDANESGFESYEALPQHKLTCFSVYCKHGHLC
SQ PIDTGLIEKNIELFFSGSAKPIYDDDPSLEGGVNGKNLGPINEWWITGFDGGEKALIGFS
SQ TSFAEYILMDPSPEYAPIFGLMQEKIYISKIVVEFLQSNSDSTYEDLINKIETTVPPSGL
SQ NLNRFTEDSLLRHAQFVVEQVESYDEAGDSDEQPIFLTPCMRDLIKLAGVTLGQRRAQAR
SQ RQTIRHSTREKDRGPTKATTTKLVYQIFDTFFAEQIEKDDREDKENAFKRRRCGVCEVCQ
SQ QPECGKCKACKDMVKFGGSGRSKQACQERRCPNMAMKEADDDEEVDDNIPEMPSPKKMHQ
SQ GKKKKQNKNRISWVGEAVKTDGKKSYYKKVCIDAETLEVGDCVSVIPDDSSKPLYLARVT
SQ ALWEDSSNGQMFHAHWFCAGTDTVLGATSDPLELFLVDECEDMQLSYIHSKVKVIYKAPS
SQ ENWAMEGGMDPESLLEGDDGKTYFYQLWYDQDYARFESPPKTQPTEDNKFKFCVSCARLA
SQ EMRQKEIPRVLEQLEDLDSRVLYYSATKNGILYRVGDGVYLPPEAFTFNIKLSSPVKRPR
SQ KEPVDEDLYPEHYRKYSDYIKGSNLDAPEPYRIGRIKEIFCPKKSNGRPNETDIKIRVNK
SQ FYRPENTHKSTPASYHADINLLYWSDEEAVVDFKAVQGRCTVEYGEDLPECVQVYSMGGP
SQ NRFYFLEAYNAKSKSFEDPPNHARSPGNKGKGKGKGKGKPKSQACEPSEPEIEIKLPKLR
SQ TLDVFSGCGGLSEGFHQAGISDTLWAIEMWDPAAQAFRLNNPGSTVFTEDCNILLKLVMA
SQ GETTNSRGQRLPQKGDVEMLCGGPPCQGFSGMNRFNSRTYSKFKNSLVVSFLSYCDYYRP
SQ RFFLLENVRNFVSFKRSMVLKLTLRCLVRMGYQCTFGVLQAGQYGVAQTRRRAIILAAAP
SQ GEKLPLFPEPLHVFAPRACQLSVVVDDKKFVSNITRLSSGPFRTITVRDTMSDLPEVRNG
SQ ASALEISYNGEPQSWFQRQLRGAQYQPILRDHICKDMSALVAARMRHIPLAPGSDWRDLP
SQ NIEVRLSDGTMARKLRYTHHDRKNGRSSSGALRGVCSCVEAGKACDPAARQFNTLIPWCL
SQ PHTGNRHNHWAGLYGRLEWDGFFSTTVTNPEPMGKQGRVLHPEQHRVVSVRECARSQGFP
SQ DTYRLFGNILDKHRQVGNAVPPPLAKAIGLEIKLCMLAKARESASAKIKEEEAAKD
XX
SC Swiss-Prot#P26358-1
XX
FT 16 106 
PF06464; DMAP_binding.
FT 645 691 
PF02008; zf-CXXC.
FT 646 692 
PS51058; ZF_CXXC.
FT 755 880 
PF01426; BAH.
FT 755 880 
PS51038; BAH.
FT 755 880 
SM00439; BAH_4.
FT 931 1100 
SM00439; BAH_4.
FT 966 1100 
PF01426; BAH.
FT 972 1100 
PS51038; BAH.
FT 1139 1594 
PF00145; DNA_methylase.
XX
IN T25008 pRb; Mammalia.
IN T30231 SIRT1-isoform1; human, Homo sapiens.
IN T30703 SIRT1; Mammalia.
IN T06312 SNA; human, Homo sapiens.
IN T15704 SNA; Mammalia.
XX
DR TRANSPATH: MO000085407.
DR UniProtKB: P26358-1; DNMT1_HUMAN.
XX
RN [1]; RE0044046.
RX PUBMED: 12171929.
RA Ohta S., Shiomi Y., Sugimoto K., Obuse C., Tsurimoto T.
RT A proteomics approach to identify proliferating cell nuclear antigen (PCNA)-binding proteins in human cell lysates. Identification of the human CHL12/RFCs2-5 complex as a novel PCNA-binding protein
RL J. Biol. Chem. 277:40362-7 (2002).
RN [2]; RE0053042.
RX PUBMED: 10888886.
RA Robertson K. D., Ait-Si-Ali S., Yokochi T., Wade P. A., Jones P. L., Wolffe A. P.
RT DNMT1 forms a complex with Rb, E2F1 and HDAC1 and represses transcription from E2F-responsive promoters.
RL Nat. Genet. 25:338-342 (2000).
XX
//