AC T06312
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ID T06312
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DT 26.10.2004 (created); mkl.
DT 08.09.2015 (updated); jmh.
CO Copyright (C), QIAGEN.
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FA SNA
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SY dJ710H13.1; SLUGH2; Sna; SNAH; SNAI1; Snail; snail homolog 1 (Drosophila).
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OS human, Homo sapiens
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; primates
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GE G010170 SNAI1; HGNC: SNAI1.
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HO Sn (Drosophila) T00751.
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CL C0001; CH; 2.3.3.2.1.
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SF a phosphorylated beta-TrCP destruction motif (DSGXXS) is required for binding of the E3 ubiquitin-ligase complex component beta-TrCP and for subsequent ubiquitination and degradation [1];
SF GSK3beta phosphorylates two serine residues that are in the beta-TrCP destruction motif [1];
SF a second GSK3beta phosphorylation motif induces translocalization from nucleus to cytoplasm [1];
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FF repressor of E-cadherin [1];
FF SNA has half-life of about 25 min [1];
FF GSK3beta is an inhibitory regulator of SNA that destabilizes it by phosphorylation [1];
FF SNA can induce epithelial-mesenchymal transition in breast epithelial cells by repressing E-cadherin expression [1];
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IN T02872 beta-catenin; human, Homo sapiens.
IN T25729 Dnmt1-isoform1; human, Homo sapiens.
IN T06570 Dnmt1; human, Homo sapiens.
IN T25625 hdac2; human, Homo sapiens.
IN T14055 PARP; human, Homo sapiens.
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MX M03566 V$SNA_Q4.
MX M07430 V$SNA_Q6.
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BS R37778.
BS R34757.
BS R37440.
BS R37443.
BS R59220.
BS R66349.
BS R37568.
BS R71633.
BS R71636.
BS R69561.
BS R69562.
BS R69564.
BS R69565.
BS R69567.
BS R38797.
BS R38799.
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DR TRANSPATH: MO000044348.
DR UniProtKB: O95863;
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RN [1]; RE0025033.
RX PUBMED: 15448698.
RA Zhou B. P., Deng J., Xia W., Xu J., Li Y. M., Gunduz M., Hung M. C.
RT Dual regulation of Snail by GSK-3beta-mediated phosphorylation in control of epithelial-mesenchymal transition.
RL Nat. Cell Biol. 6:931-940 (2004).
RN [2]; RE0067519.
RX PUBMED: 19955572.
RA Vinas-Castells R., Beltran M., Valls G., Gomez I., Garcia J. M., Montserrat-Sentis B., Baulida J., Bonilla F., de Herreros A. G., Diaz V. M.
RT The hypoxia-controlled FBXL14 ubiquitin ligase targets SNAIL1 for proteasome degradation.
RL J. Biol. Chem. 285:3794-3805 (2010).
RN [3]; RE0071767.
RX PUBMED: 20534591.
RA Kim Y., Park H., Park D., Lee Y. S., Choe J., Hahn J. H., Lee H., Kim Y. M., Jeoung D.
RT Cancer/testis antigen CAGE exerts negative regulation on p53 expression through HDAC2 and confers resistance to anti-cancer drugs.
RL J. Biol. Chem. 285:25957-25968 (2010).
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