AC T06570
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ID T06570
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DT 26.04.2005 (created); ili.
DT 20.01.2015 (updated); spk.
CO Copyright (C), QIAGEN.
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FA Dnmt1
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SY AIM; CXXC9; DNA (cytosine-5-)-methyltransferase 1; DNA methyltransferase HsaI; DNA MTase HsaI; DNMT; DNMT1; M.HsaI; MCMT.
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OS human, Homo sapiens
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; primates
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GE G018186 DNMT1; HGNC: DNMT1.
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CL C0070; CXXC; 2.6.1.0.6.
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IN T22468 BCL11A-isoform1; human, Homo sapiens.
IN T08470 Daxx-isoform1; human, Homo sapiens.
IN T27198 DNA (cytosine-5)-methyltransferase 3B; human, Homo sapiens.
IN T09117 E2F-1; human, Homo sapiens.
IN T02997 E2F-6; human, Homo sapiens.
IN T25624 p/CAF; human, Homo sapiens.
IN T00722 pRb; human, Homo sapiens.
IN T00594 RelA-p65-isoform1; human, Homo sapiens.
IN T08711 RelA-p65; human, Homo sapiens.
IN T29717 SIRT1; human, Homo sapiens.
IN T06312 SNA; human, Homo sapiens.
IN T15014 SNA; human, Homo sapiens.
IN T00759 Sp1; human, Homo sapiens.
IN T20156 uhrf1-isoform1; human, Homo sapiens.
IN T20157 uhrf1; human, Homo sapiens.
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DR TRANSPATH: MO000054397.
DR UniProtKB: P26358;
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RN [1]; RE0035141.
RX PUBMED: 11259406.
RA Song J., Ugai H., Kanazawa I., Sun K., Yokoyama K. K.
RT Independent repression of a GC-rich housekeeping gene by Sp1 and MAZ involves the same cis-elements.
RL J. Biol. Chem. 276:19897-19904 (2001).
RN [2]; RE0037668.
RX PUBMED: 15120635.
RA Geiman T. M., Sankpal U. T., Robertson A. K., Zhao Y., Zhao Y., Robertson K. D.
RT DNMT3B interacts with hSNF2H chromatin remodeling enzyme, HDACs 1 and 2, and components of the histone methylation system
RL Biochem. Biophys. Res. Commun. 318:544-55 (2004).
RN [3]; RE0048111.
RX PUBMED: 12354094.
RA Iida T., Suetake I., Tajima S., Morioka H., Ohta S., Obuse C., Tsurimoto T.
RT PCNA clamp facilitates action of DNA cytosine methyltransferase 1 on hemimethylated DNA.
RL Genes Cells 7:997-1007 (2002).
RN [4]; RE0048227.
RX PUBMED: 15899874.
RA Ghoshal K., Datta J., Majumder S., Bai S., Kutay H., Motiwala T., Jacob S. T.
RT 5-Aza-deoxycytidine induces selective degradation of DNA methyltransferase 1 by a proteasomal pathway that requires the KEN box, bromo-adjacent homology domain, and nuclear localization signal.
RL Mol. Cell. Biol. 25:4727-4741 (2005).
RN [5]; RE0053042.
RX PUBMED: 10888886.
RA Robertson K. D., Ait-Si-Ali S., Yokochi T., Wade P. A., Jones P. L., Wolffe A. P.
RT DNMT1 forms a complex with Rb, E2F1 and HDAC1 and represses transcription from E2F-responsive promoters.
RL Nat. Genet. 25:338-342 (2000).
RN [6]; RE0066070.
RX PUBMED: 19243219.
RA Bossuyt W., Kazanjian A., De Geest N., Van Kelst S., De Hertogh G., Geboes K., Boivin G. P., Luciani J., Fuks F., Chuah M., VandenDriessche T., Marynen P., Cools J., Shroyer N. F., Hassan B. A.
RT Atonal homolog 1 is a tumor suppressor gene.
RL PLoS Biol. 7:e39 (2009).
RN [7]; RE0069698.
RX PUBMED: 21045206.
RA Du Z., Song J., Wang Y., Zhao Y., Guda K., Yang S., Kao H. Y., Xu Y., Willis J., Markowitz S. D., Sedwick D., Ewing R. M., Wang Z.
RT DNMT1 stability is regulated by proteins coordinating deubiquitination and acetylation-driven ubiquitination.
RL Sci. Signal. 3:ra80 (2010).
RN [8]; RE0071767.
RX PUBMED: 20534591.
RA Kim Y., Park H., Park D., Lee Y. S., Choe J., Hahn J. H., Lee H., Kim Y. M., Jeoung D.
RT Cancer/testis antigen CAGE exerts negative regulation on p53 expression through HDAC2 and confers resistance to anti-cancer drugs.
RL J. Biol. Chem. 285:25957-25968 (2010).
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