AC T02997
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ID T02997
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DT 28.02.2000 (created); sth.
DT 21.07.2014 (updated); pos.
CO Copyright (C), QIAGEN.
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FA E2F-6
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SY E2F transcription factor 6; E2F-6; E2F6.
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OS human, Homo sapiens
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; primates
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GE G002041 E2F6; HGNC: E2F6.
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CL C0023; fork head; 3.3.2.1.6.
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SF nuclear protein;
SF can form heterodimers with DP-1 and DP-2;
SF complexes display a preference for a (TTTCCCGC) E2F recognition site, which is slightly different to the E2 promoter (TTTCGCGC) [1];
SF prior to crystal structure belongs to bHLH-zip factors [5];
SF unlike E2F 1-5 lacks a transactivation and a pocket protein binding domain;
SF contains a modular repression domain at its carboxyl terminus [2];
SF does not bind any pRb family proteins( pRB, p107, p130) [4];
SF bind to a variation of the E2F consensus sequence, possibly competing with other E2F complexes [1];
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EX brain,,,adult; detectable; Northern blot; mRNA (poly-A); [3].
EX brain,,,adult; none; Northern blot; total RNA; [1].
EX colon,,,adult; none; Northern blot; total RNA; [1].
EX heart,,,adult; detectable; Northern blot; mRNA (poly-A); [3].
EX heart,,,adult; low; Northern blot; total RNA; [1].
EX kidney (right and left),,,adult; detectable; Northern blot; mRNA (poly-A); [3].
EX liver,,,adult; detectable; Northern blot; mRNA (poly-A); [3].
EX lung (right and left),,,adult; detectable; Northern blot; mRNA (poly-A); [3].
EX muscles,,,adult; detectable; Northern blot; mRNA (poly-A); [3].
EX ovary (right and left),,,adult; none; Northern blot; total RNA; [1].
EX pancreas,,,adult; detectable; Northern blot; mRNA (poly-A); [3].
EX placenta,,,adult; detectable; Northern blot; mRNA (poly-A); [3].
EX placenta,,,adult; low; Northern blot; total RNA; [1].
EX prostate gland,,,adult; none; Northern blot; total RNA; [1].
EX small intestine,,,adult; high; Northern blot; total RNA; [1].
EX spleen,,,adult; low; Northern blot; total RNA; [1].
EX testis (right and left),,,adult; high; Northern blot; total RNA; [1].
EX thymus,,,adult; none; Northern blot; total RNA; [1].
XX
FF transcriptional repressor protein with important role in regulation of cell cycle [1];
FF E2F-6:DP represses directly transcription in contrast to other E2F-species [2];
FF complex represses a subset of E2F-responsive genes [1];
FF overproduction had no specific effect on cell cycle progression in asynchronously growing Saos2 and NIH 3T3 cells [2];
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IN T19002 BRAF35; human, Homo sapiens.
IN T04074 brca1; human, Homo sapiens.
IN T05451 BRG1; human, Homo sapiens.
IN T06570 Dnmt1; human, Homo sapiens.
IN T33307 DNTTIP1; human, Homo sapiens.
IN T01548 DP-1; human, Homo sapiens.
IN T03000 DP-2; human, Homo sapiens.
IN T03414 Miz-1; human, Homo sapiens.
IN T01804 NF-YA; human, Homo sapiens.
IN T19382 TZFP; human, Homo sapiens.
IN T18921 ZFPM2; human, Homo sapiens.
XX
MX M01252 V$E2F6_01.
MX M04790 V$E2F6_02.
MX M07085 V$E2F6_03.
MX M08875 V$E2F_Q4_03.
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BS R30955.
BS R25714.
BS R25717.
BS R25613.
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DR TRANSPATH: MO000026948.
DR UniProtKB: O75461; E2F6_HUMAN.
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RN [1]; RE0014132.
RX PUBMED: 9704927.
RA Cartwright P., Mueller H., Wagener C., Holm K., Helin K.
RT E2F-6: a novel member of the E2F family is an inhibitor of E2F-dependent transcription
RL Oncogene 17:611-623 (1998).
RN [2]; RE0014135.
RX PUBMED: 9689056.
RA Gaubatz S., Wood J. G., Livingston D. M.
RT Unusual proliferation arrest and transcriptional control properties of a newly discovered E2F family member, E2F-6.
RL Proc. Natl. Acad. Sci. USA 95:9190-9195 (1998).
RN [3]; RE0014136.
RX PUBMED: 9501179.
RA Trimarchi J. M., Fairchild B., Verona R., Moberg K., Andon N., Lees J. A.
RT E2F-6, a member of the E2F family that can behave as a transcriptional repressor
RL Proc. Natl. Acad. Sci. USA 95:2850-2855 (1998).
RN [4]; RE0014143.
RX PUBMED: 10436023.
RA Kohn K. W.
RT Molecular interaction map of the mammalian cell cycle control and DNA repair systems
RL Mol. Biol. Cell 10:2703-2734 (1999).
RN [5]; RE0015322.
RX PUBMED: 10090723.
RA Zheng N., Fraenkel E., Pabo C. O., Pavletich N. P.
RT Structural basis of DNA recognition by the heterodimeric cell cycle transcription factor E2F-DP
RL Genes Dev. 13:666-674 (1999).
RN [6]; RE0050908.
RX PUBMED: 17096023.
RA Yang W. W., Wang Z. H., Zhu Y., Yang H. T.
RT E2F6 negatively regulates ultraviolet-induced apoptosis via modulation of BRCA1.
RL Cell Death Differ. 14:807-817 (2007).
XX
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