AC T03414
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ID T03414
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DT 05.06.2000 (created); sth.
DT 31.05.2015 (updated); pro.
CO Copyright (C), QIAGEN.
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FA Miz-1
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SY MIZ1; Myc-interacting Zn finger protein-1; pHZ-67; RP1-134O19.2; ZBTB17; zinc finger and BTB domain containing 17; zinc finger protein 151 (pHZ-67); ZNF151; ZNF60.
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OS human, Homo sapiens
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; primates
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GE G006898 ZBTB17; HGNC: ZBTB17.
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CL C0001; CH; 2.3.4.0.72.
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SF BTB/POZ domain Zn finger protein that specifically interacts with Myc, but not with Max or USF [1];
SF binding of Myc to miz-1 requires the HLH domain of Myc and a short amphipathic helix located in the carboxy-terminus of Miz-1 [1];
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FF transcriptional regulator;
FF in vivo potent growth arrest function in several rodent and human cell lines [1];
FF Miz-1 is involved in gene repression by Myc in vivo [2];
FF the C-terminal fragment of MAGE-A4 complexes with Miz-1 at the p21WAF1 promoter and inhibits transcriptional activity of Miz-1 on the p21WAF1 promoter [3];
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IN T06242 c-Myc-isoform1:Max; human, Homo sapiens.
IN T00140 c-Myc-isoform1; human, Homo sapiens.
IN T09117 E2F-1; human, Homo sapiens.
IN T14606 E2F-3; human, Homo sapiens.
IN T02997 E2F-6; human, Homo sapiens.
IN T25286 ZBTB7C; Mammalia.
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BS R15323.
BS R31053.
BS R31042.
BS R31043.
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DR TRANSPATH: MO000027350.
DR UniProtKB: Q13105;
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RN [1]; RE0013466.
RX PUBMED: 9312026.
RA Peukert K., Staller P., Schneider A., Carmichael G., Hanel F., Eilers M.
RT An alternative pathway for gene regulation by Myc
RL EMBO J. 16:5672-5686 (1997).
RN [2]; RE0014565.
RX PUBMED: 9308237.
RA Schneider A., Peukert K., Eilers M., Hanel F.
RT Association of Myc with the zinc-finger protein Miz-1 defines a novel pathway for gene regulation by Myc
RL Curr. Top. Microbiol. Immunol. 224:137-146 (1997).
RN [3]; RE0024524.
RX PUBMED: 14739298.
RA Sakurai T., Itoh K., Higashitsuji H., Nagao T., Nonoguchi K., Chiba T., Fujita J.
RT A cleaved form of MAGE-A4 binds to Miz-1 and induces apoptosis in human cells.
RL J. Biol. Chem. 279:15505-15514 (2004).
RN [4]; RE0052226.
RX PUBMED: 17006541.
RA Liu K., Paik J. C., Wang B., Lin F. T., Lin W. C.
RT Regulation of TopBP1 oligomerization by Akt/PKB for cell survival.
RL EMBO J. 25:4795-4807 (2006).
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