AC T30231
XX
ID T30231
XX
DT 10.08.2006 (created); man.
DT 02.07.2014 (updated); spk.
CO Copyright (C), QIAGEN.
XX
FA SIRT1-isoform1
XX
SY silent information regulator type 1; SIR2alpha; sirtuin type 1; yeast silent information regulator 2 (Sir2p) homolog.
XX
OS human, Homo sapiens
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; primates
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GE G003806 SIRT1; HGNC: SIRT1.
XX
SZ 747 AA; 81.7 kDa (cDNA) (calc.).
XX
SQ MADEAALALQPGGSPSAAGADREAASSPAGEPLRKRPRRDGPGLERSPGEPGGAAPEREV
SQ PAAARGCPGAAAAALWREAEAEAAAAGGEQEAQATAAAGEGDNGPGLQGPSREPPLADNL
SQ YDEDDDDEGEEEEEAAAAAIGYRDNLLFGDEIITNGFHSCESDEEDRASHASSSDWTPRP
SQ RIGPYTFVQQHLMIGTDPRTILKDLLPETIPPPELDDMTLWQIVINILSEPPKRKKRKDI
SQ NTIEDAVKLLQECKKIIVLTGAGVSVSCGIPDFRSRDGIYARLAVDFPDLPDPQAMFDIE
SQ YFRKDPRPFFKFAKEIYPGQFQPSLCHKFIALSDKEGKLLRNYTQNIDTLEQVAGIQRII
SQ QCHGSFATASCLICKYKVDCEAVRGDIFNQVVPRCPRCPADEPLAIMKPEIVFFGENLPE
SQ QFHRAMKYDKDEVDLLIVIGSSLKVRPVALIPSSIPHEVPQILINREPLPHLHFDVELLG
SQ DCDVIINELCHRLGGEYAKLCCNPVKLSEITEKPPRTQKELAYLSELPPTPLHVSEDSSS
SQ PERTSPPDSSVIVTLLDQAAKSNDDLDVSESKGCMEEKPQEVQTSRNVESIAEQMENPDL
SQ KNVGSSTGEKNERTSVAGTVRKCWPNRVAKEQISRRLDGNQYLFLPPNRYIFHGAEVYSD
SQ SEDDVLSSSSCGSNSDSGTCQSPSLEEPMEDESEIEEFYNGLEDEPDVPERAGGAGFGTD
SQ GDDQEAINEAISVKQEVTDMNYPSNKS
XX
SC translated from EMBL:AF235040
XX
FT 244 498 
PS50305; SIRTUIN.
FT 261 447 
PF02146; SIR2.
XX
IN T08487 AR-isoform1; human, Homo sapiens.
IN T18797 ATFa; human, Homo sapiens.
IN T08776 c-Fos; human, Homo sapiens.
IN T00133 c-Jun; human, Homo sapiens.
IN T08461 c-Jun; human, Homo sapiens.
IN T04197 CLIM2; human, Homo sapiens.
IN T08562 CREB1; human, Homo sapiens.
IN T25729 Dnmt1-isoform1; human, Homo sapiens.
IN T14067 FOXO1A; Mammalia.
IN T01686 GCN5; human, Homo sapiens.
IN T04892 HES-1; human, Homo sapiens.
IN T09934 Hey2; human, Homo sapiens.
IN T02853 hnRNPK; human, Homo sapiens.
IN T14490 hnRNPK; Mammalia.
IN T01978 JunD; human, Homo sapiens.
IN T27204 MOF-isoform1; human, Homo sapiens.
IN T01427 p300; human, Homo sapiens.
IN T00671 p53; human, Homo sapiens.
IN T14055 PARP; human, Homo sapiens.
IN T22316 PDCD2; human, Homo sapiens.
IN T17026 RNF96; human, Homo sapiens.
IN T01493 STAT3; human, Homo sapiens.
IN T14458 STAT3; Mammalia.
IN T00857 TTF-1; human, Homo sapiens.
IN T34373 ZNF346; human, Homo sapiens.
XX
DR TRANSPATH: MO000084718.
DR EMBL: AF235040;
DR UniProtKB: Q96EB6;
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RN [1]; RE0020825.
RX PUBMED: 11672522.
RA Luo J., Nikolaev A. Y., Imai S., Chen D., Su F., Shiloh A., Guarente L., Gu W.
RT Negative control of p53 by Sir2alpha promotes cell survival under stress
RL Cell 107:137-148 (2001).
RN [2]; RE0042136.
RX PUBMED: 12535671.
RA Takata T., Ishikawa F.
RT Human Sir2-related protein SIRT1 associates with the bHLH repressors HES1 and HEY2 and is involved in HES1- and HEY2-mediated transcriptional repression
RL Biochem. Biophys. Res. Commun. 301:250-7 (2003).
RN [3]; RE0048104.
RX PUBMED: 15632193.
RA Bouras T., Fu M., Sauve A. A., Wang F., Quong A. A., Perkins N. D., Hay R. T., Gu W., Pestell R. G.
RT SIRT1 deacetylation and repression of p300 involves lysine residues 1020/1024 within the cell cycle regulatory domain 1.
RL J. Biol. Chem. 280:10264-10276 (2005).
RN [4]; RE0048317.
RX PUBMED: 15692560.
RA Yang Y., Hou H., Haller E. M., Nicosia S. V., Bai W.
RT Suppression of FOXO1 activity by FHL2 through SIRT1-mediated deacetylation.
RL EMBO J. 24:1021-1032 (2005).
RN [5]; RE0049242.
RX PUBMED: 16923962.
RA Fu M., Liu M., Sauve A. A., Jiao X., Zhang X., Wu X., Powell M. J., Yang T., Gu W., Avantaggiati M. L., Pattabiraman N., Pestell T. G., Wang F., Quong A. A., Wang C., Pestell R. G.
RT Hormonal control of androgen receptor function through SIRT1.
RL Mol. Cell. Biol. 26:8122-8135 (2006).
RN [6]; RE0066089.
RX PUBMED: 20042607.
RA Zhang R., Chen H. Z., Liu J. J., Jia Y. Y., Zhang Z. Q., Yang R. F., Zhang Y., Xu J., Wei Y. S., Liu D. P., Liang C. C.
RT SIRT1 Suppresses Activator Protein-1 Transcriptional Activity and Cyclooxygenase-2 Expression in Macrophages.
RL J. Biol. Chem. 285:7097-7110 (2010).
RN [7]; RE0069450.
RX PUBMED: 21245319.
RA Liu X., Wang D., Zhao Y., Tu B., Zheng Z., Wang L., Wang H., Gu W., Roeder R. G., Zhu W. G.
RT Methyltransferase Set7/9 regulates p53 activity by interacting with Sirtuin 1 (SIRT1).
RL Proc. Natl. Acad. Sci. USA 108:1925-1930 (2011).
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