AC T00857
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ID T00857
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DT 28.01.1993 (created); hse.
DT 21.05.2015 (updated); pro.
CO Copyright (C), QIAGEN.
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FA TTF-1
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SY Nkx-2.1; Nkx2.1; T/EBP; thyroid nuclear factor 1; thyroid transcription factor 1; thyroid-specific enhancer-binding protein; TTF-1.
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OS human, Homo sapiens
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; primates
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GE G001229 NKX2-1; HGNC: Nkx2-1.
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HO NK-2 (Drosophila).
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CL C0053; NK-2/Nkx; 3.1.2.14.1.
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SF strong homology ( 98%) to the mouse TTF-1 with absolute conservation of the 60 AA homeodomain [4];
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CP thyroid gland epithelium; lung (alveolar type II cells and bronchiolar epithelial cells) [3].
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FF plays an important role in the regulation of lung development and surfactant homeostasis [3];
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IN T08711 RelA-p65; human, Homo sapiens.
IN T30231 SIRT1-isoform1; human, Homo sapiens.
IN T09538 Smad3; Mammalia.
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MX M01312 V$NKX21_01.
MX M00432 V$TITF1_Q3.
MX M02034 V$TTF1_Q5.
MX M03891 V$TTF1_Q5_01.
MX M00794 V$TTF1_Q6.
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BS R36425.
BS R67726.
BS R35607.
BS R39565.
BS R67724.
BS R29761.
BS R29762.
BS R04657.
BS R13140.
BS R12979.
BS R12981.
BS R58059.
BS R21192.
BS R21193.
BS R58060.
BS R28628.
BS R28629.
BS R35606.
BS R35555.
BS R35556.
BS R22642.
BS R22643.
BS R14700.
BS R13192.
BS R14696.
BS R14699.
BS R36426.
BS R13210.
BS R13198.
BS R28631.
BS R02257.
BS R04645.
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DR TRANSPATH: MO000025223.
DR UniProtKB: P43699;
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RN [1]; RE0005380.
RX PUBMED: 7711080.
RA Saiardi A., Tassi V., de Filippis V., Civitareale D.
RT Cloning and sequence analysis of human thyroid transcription factor 1
RL Biochim. Biophys. Acta 1261:307-310 (1995).
RN [2]; RE0005381.
RX PUBMED: 7711079.
RA Oguchi H., Pan Y. T., Kimura S.
RT The complete nucleotide sequence of the mouse thyroid-specific enhancer-binding protein (T/EBP) gene: extensive identity of the deduced amino acid sequence with the human protein
RL Biochim. Biophys. Acta 1261:304-306 (1995).
RN [3]; RE0005382.
RX PUBMED: 7713914.
RA Ikeda K., Clark J. C., Shaw-White J. R., Stahlman M. T., Boutell C. J., Whitsett J. A.
RT Gene structure and expression of human TTF-1 in respiratory epithelial cells
RL J. Biol. Chem. 270:8108-8114 (1995).
RN [4]; RE0013773.
RX PUBMED: 9570141.
RA Bingle C. D.
RT Thyroid transcription factor-1
RL Int. J. Biochem. Cell Biol. 29:1471-1473 (1997).
RN [5]; RE0022446.
RX PUBMED: 12161428.
RA Li C., Zhu N. L., Tan R. C., Ballard P. L., Derynck R., Minoo P.
RT Transforming growth factor-beta inhibits pulmonary surfactant protein B gene transcription through SMAD3 interactions with NKX2.1 and HNF-3 transcription factors.
RL J. Biol. Chem. 277:38399-38408 (2002).
RN [6]; RE0046041.
RX PUBMED: 12040027.
RA Islam K. N., Mendelson C. R.
RT Potential role of nuclear factor kappaB and reactive oxygen species in cAMP and cytokine regulation of surfactant protein-A gene expression in lung type II cells
RL Mol. Endocrinol. 16:1428-40 (2002).
RN [7]; RE0049369.
RX PUBMED: 11152647.
RA Yang Y. S., Yang M. C., Wang B., Weissler J. C.
RT BR22, a novel protein, interacts with thyroid transcription factor-1 and activates the human surfactant protein B promoter.
RL Am. J. Respir. Cell Mol. Biol. 24:30-37 (2001).
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