TRANSFAC FACTOR TABLE, Release 2017.2 - public - 2017-06-30, (C) QIAGEN

AC T00857 XX ID T00857 XX DT 28.01.1993 (created); hse. DT 21.05.2015 (updated); pro. CO Copyright (C), QIAGEN. XX FA TTF-1 XX SY Nkx-2.1; Nkx2.1; T/EBP; thyroid nuclear factor 1; thyroid transcription factor 1; thyroid-specific enhancer-binding protein; TTF-1. XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; primates XX GE G001229 NKX2-1; HGNC: Nkx2-1. XX HO NK-2 (Drosophila). XX CL C0053; NK-2/Nkx; XX SF strong homology ( 98%) to the mouse TTF-1 with absolute conservation of the 60 AA homeodomain [4]; XX CP thyroid gland epithelium; lung (alveolar type II cells and bronchiolar epithelial cells) [3]. XX FF plays an important role in the regulation of lung development and surfactant homeostasis [3]; XX IN T08711 RelA-p65; human, Homo sapiens. IN T30231 SIRT1-isoform1; human, Homo sapiens. IN T09538 Smad3; Mammalia. XX MX M01312 V$NKX21_01. MX M00432 V$TITF1_Q3. MX M02034 V$TTF1_Q5. MX M03891 V$TTF1_Q5_01. MX M00794 V$TTF1_Q6. XX BS R36425. BS R67726. BS R35607. BS R39565. BS R67724. BS R29761. BS R29762. BS R04657. BS R13140. BS R12979. BS R12981. BS R58059. BS R21192. BS R21193. BS R58060. BS R28628. BS R28629. BS R35606. BS R35555. BS R35556. BS R22642. BS R22643. BS R14700. BS R13192. BS R14696. BS R14699. BS R36426. BS R13210. BS R13198. BS R28631. BS R02257. BS R04645. XX DR TRANSPATH: MO000025223. DR UniProtKB: P43699; XX RN [1]; RE0005380. RX PUBMED: 7711080. RA Saiardi A., Tassi V., de Filippis V., Civitareale D. RT Cloning and sequence analysis of human thyroid transcription factor 1 RL Biochim. Biophys. Acta 1261:307-310 (1995). RN [2]; RE0005381. RX PUBMED: 7711079. RA Oguchi H., Pan Y. T., Kimura S. RT The complete nucleotide sequence of the mouse thyroid-specific enhancer-binding protein (T/EBP) gene: extensive identity of the deduced amino acid sequence with the human protein RL Biochim. Biophys. Acta 1261:304-306 (1995). RN [3]; RE0005382. RX PUBMED: 7713914. RA Ikeda K., Clark J. C., Shaw-White J. R., Stahlman M. T., Boutell C. J., Whitsett J. A. RT Gene structure and expression of human TTF-1 in respiratory epithelial cells RL J. Biol. Chem. 270:8108-8114 (1995). RN [4]; RE0013773. RX PUBMED: 9570141. RA Bingle C. D. RT Thyroid transcription factor-1 RL Int. J. Biochem. Cell Biol. 29:1471-1473 (1997). RN [5]; RE0022446. RX PUBMED: 12161428. RA Li C., Zhu N. L., Tan R. C., Ballard P. L., Derynck R., Minoo P. RT Transforming growth factor-beta inhibits pulmonary surfactant protein B gene transcription through SMAD3 interactions with NKX2.1 and HNF-3 transcription factors. RL J. Biol. Chem. 277:38399-38408 (2002). RN [6]; RE0046041. RX PUBMED: 12040027. RA Islam K. N., Mendelson C. R. RT Potential role of nuclear factor kappaB and reactive oxygen species in cAMP and cytokine regulation of surfactant protein-A gene expression in lung type II cells RL Mol. Endocrinol. 16:1428-40 (2002). RN [7]; RE0049369. RX PUBMED: 11152647. RA Yang Y. S., Yang M. C., Wang B., Weissler J. C. RT BR22, a novel protein, interacts with thyroid transcription factor-1 and activates the human surfactant protein B promoter. RL Am. J. Respir. Cell Mol. Biol. 24:30-37 (2001). XX //