AC T09934
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ID T09934
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DT 21.11.2006 (created); kau.
DT 27.03.2008 (updated); dbh.
CO Copyright (C), QIAGEN.
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FA Hey2
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SY basic helix-loop-helix factor 1; CHF1; gridlock; hairy and enhancer of split related-2; hairy-related transcription factor 2; HERP1; Hes-related repressor protein 1; HRT2.
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OS human, Homo sapiens
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; primates
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GE G004060 HEY2; HGNC: Hey2.
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CL C0010; bHLH.
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SZ 337 AA; 35.8 kDa (cDNA) (calc.).
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SQ MKRPCEETTSESDMDETIDVGSENNYSGQSTSSVIRLNSPTTTSQIMARKKRRGIIEKRR
SQ RDRINNSLSELRRLVPTAFEKQGSAKLEKAEILQMTVDHLKMLQATGGKGYFDAHALAMD
SQ FMSIGFRECLTEVARYLSSVEGLDSSDPLRVRLVSHLSTCATQREAAAMTSSMAHHHHPL
SQ HPHHWAAAFHHLPAALLQPNGLHASESTPCRLSTTSEVPPAHGSALLTATFAHADSALRM
SQ PSTGSVAPCVPPLSTSLLSLSATVHAAAAAATAAAHSFPLSFAGAFPMLPPNAAAAVAAA
SQ TAISPPLSVSATSSPQQTSSGTNNKPYRPWGTEVGAF
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SC translated from EMBL #AJ249545
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FT 6 292 
PF00478; IMP dehydrogenase / GMP reductase domain.
FT 49 61 
basic region [1].
FT 49 103 
basic helix-loop-helix domain [1].
FT 49 104 
PS50888; HLH.
FT 51 104 
PF00010; Helix-loop-helix DNA-binding domain.
FT 54 109 
SM00353; finulus.
FT 62 103 
helix-loop-helix motif [1].
FT 119 166 
SM00511; ORANGE.
FT 120 164 
orange domain [1].
FT 120 166 
PF07527; Hairy Orange.
FT 122 157 PS51054; ORANGE.
FT 327 330 YRPW motif [7].
FT 332 337 conserved motif TE(I/V)GAF [1].
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IN T01346 arnt-isoform1; human, Homo sapiens.
IN T21852 HDAC1; Mammalia.
IN T30231 SIRT1-isoform1; human, Homo sapiens.
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MX M08885 V$HAIRYLIKE_Q3.
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BS R12364.
BS R10227.
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DR TRANSPATH: MO000092780.
DR EMBL: AJ249545;
DR UniProtKB: Q9UBP5;
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RN [1]; RE0017655.
RX PUBMED: 10588864.
RA Nakagawa O., Nakagawa M., Richardson J. A., Olson E. N., Srivastava D.
RT HRT1, HRT2, and HRT3: a new subclass of bHLH transcription factors marking specific cardiac, somitic, and pharyngeal arch segments.
RL Dev. Biol. 216:72-84 (1999).
RN [2]; RE0017656.
RX PUBMED: 10860664.
RA Steidl C., Leimeister C., Klamt B., Maier M., Nanda I., Dixon M., Clarke R., Schmid M., Gessler M.
RT Characterization of the human and mouse HEY1, HEY2, and HEYL genes: cloning, mapping, and mutation screening of a new bHLH gene family
RL Genomics 66:195-203 (2000).
RN [3]; RE0017667.
RX PUBMED: 11095750.
RA Nakagawa O., McFadden D. G., Nakagawa M., Yanagisawa H., Hu T., Srivastava D., Olson E. N.
RT Members of the HRT family of basic helix-loop-helix proteins act as transcriptional repressors downstream of Notch signaling.
RL Proc. Natl. Acad. Sci. USA 97:13655-13660 (2000).
RN [4]; RE0042136.
RX PUBMED: 12535671.
RA Takata T., Ishikawa F.
RT Human Sir2-related protein SIRT1 associates with the bHLH repressors HES1 and HEY2 and is involved in HES1- and HEY2-mediated transcriptional repression
RL Biochem. Biophys. Res. Commun. 301:250-7 (2003).
RN [5]; RE0048851.
RX PUBMED: 11486045.
RA Iso T., Sartorelli V., Poizat C., Iezzi S., Wu H. Y., Chung G., Kedes L., Hamamori Y.
RT HERP, a novel heterodimer partner of HES/E(spl) in Notch signaling.
RL Mol. Cell. Biol. 21:6080-6089 (2001).
RN [6]; RE0049770.
RX PUBMED: 15684393.
RA Belandia B., Powell S. M., Garcia-Pedrero J. M., Walker M. M., Bevan C. L., Parker M. G.
RT Hey1, a mediator of notch signaling, is an androgen receptor corepressor.
RL Mol. Cell. Biol. 25:1425-1436 (2005).
RN [7]; RE0017201.
RX PUBMED: 10692439.
RA Chin M. T., Maemura K., Fukumoto S., Jain M. K., Layne M. D., Watanabe M., Hsieh C. M., Lee M. E.
RT Cardiovascular basic helix loop helix factor 1, a novel transcriptional repressor expressed preferentially in the developing and adult cardiovascular system
RL J. Biol. Chem. 275:6381-6387 (2000).
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