AC T04892
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ID T04892
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DT 21.11.2001 (created); rge.
DT 20.12.2013 (updated); yre.
CO Copyright (C), QIAGEN.
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FA HES-1
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SY hair enhancer of split 1; hairy and enhancer of split 1; hairy homolog; hairy-like; HES1; HHL; HL; HRY.
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OS human, Homo sapiens
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; primates
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GE G006195 HES1; HGNC: Hes1.
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CL C0010; bHLH.
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SZ 280 AA; 29.5 kDa (cDNA) (calc.).
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SQ MPADIMEKNSSSPVAATPASVNTTPDKPKTASEHRKSSKPIMEKRRRARINESLSQLKTL
SQ ILDALKKDSSRHSKLEKADILEMTVKHLRNLQRAQMTAALSTDPSVLGKYRAGFSECMNE
SQ VTRFLSTCEGVNTEVRTRLLGHLANCMTQINAMTYPGQPHPALQAPPPPPPGPGGPQHAP
SQ FAPPPPLVPIPGGAAPPPGGAPCKLGSQAGEAAKVFGGFQVVPAPDGQFAFLIPNGAFAH
SQ SGPVIPVYTSNSGTSVGPNAVSPSSGPSLTADSMWRPWRN
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SC translated from EMBL #L19314
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FT 34 92 
PS50888; HLH.
FT 35 92 
PF00010; Helix-loop-helix DNA-binding domain.
FT 40 97 
SM00353; finulus.
FT 108 152 
PF07527; Hairy Orange.
FT 108 152 
SM00511; ORANGE.
FT 110 143 
PS51054; ORANGE.
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CP Highly expressed in NSCLC (non small cell lung cancer) lines [3].
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IN T30231 SIRT1-isoform1; human, Homo sapiens.
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MX M01009 V$HES1_Q2.
MX M07042 V$HES1_Q3.
MX M07420 V$HES1_Q4.
MX M02011 V$HES1_Q6.
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BS R37788.
BS R20270.
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DR TRANSPATH: MO000030960.
DR EMBL: AF264785;
DR EMBL: L19314;
DR UniProtKB: Q14469;
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RN [1]; RE0017172.
RX PUBMED: 8020957.
RA Feder J. N., Li L., Jan L. Y., Jan Y. N.
RT Genomic cloning and chromosomal localization of HRY, the human homolog to the Drosophila segmentation gene, hairy
RL Genomics 20:56-61 (1994).
RN [2]; RE0042136.
RX PUBMED: 12535671.
RA Takata T., Ishikawa F.
RT Human Sir2-related protein SIRT1 associates with the bHLH repressors HES1 and HEY2 and is involved in HES1- and HEY2-mediated transcriptional repression
RL Biochem. Biophys. Res. Commun. 301:250-7 (2003).
RN [3]; RE0051512.
RX PUBMED: 9144241.
RA Chen H., Thiagalingam A., Chopra H., Borges M. W., Feder J. N., Nelkin B. D., Baylin S. B., Ball D. W.
RT Conservation of the Drosophila lateral inhibition pathway in human lung cancer: a hairy-related protein (HES-1) directly represses achaete-scute homolog-1 expression.
RL Proc. Natl. Acad. Sci. USA 94:5355-5360 (1997).
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