AC T01978
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ID T01978
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DT 29.11.1996 (created); hiwi.
DT 27.03.2015 (updated); asv.
CO Copyright (C), QIAGEN.
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FA JunD
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SY AP-1; jun D proto-oncogene; Jun-D; JUND; TRANSCRIPTION FACTOR JUN-D.
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OS human, Homo sapiens
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; primates
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GE G006330 JUND; HGNC: JUND.
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CL C0008; bZIP; 1.1.1.1.3.
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SF relatively poor sequence conservation with human JunD [3];
SF a large part of the protein is required for full trans-activation, no small activating domain can be defined [3];
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CP human endometrium from proliferative and secretory phases of the menstrual cycle and human decidua from early pregnancy [7].
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FF activator with decreasing activity at high concentrations [3];
FF some spontaneous mutants may reveal enhanced trans-activation capability in combination with Fra-2 [4];
FF no inhibition of myogenic effects of MyoD or myogenin [1];
FF quickly enhanced expression within 60 min after TPA administration [2];
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IN T15204 brca1; Mammalia.
IN T01113 Elf-1; human, Homo sapiens.
IN T01443 Nrf2; human, Homo sapiens.
IN T30231 SIRT1-isoform1; human, Homo sapiens.
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MX M00517 V$AP1_01.
MX M00924 V$AP1_Q2_01.
MX M00926 V$AP1_Q4_01.
MX M00925 V$AP1_Q6_01.
MX M04681 V$JUND_01.
MX M04776 V$JUND_02.
MX M04803 V$JUND_03.
MX M07104 V$JUND_04.
MX M07105 V$JUND_05.
MX M08934 V$JUND_06.
MX M08935 V$JUND_07.
MX M03552 V$JUND_Q6.
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BS R66333.
BS R64299.
BS R60543.
BS R70646.
BS R70685.
BS R70687.
BS R37581.
BS R30618.
BS R04348.
BS R25298.
BS R36995.
BS R61970.
BS R26709.
BS R61832.
BS R20982.
BS R29738.
BS R14540.
BS R22557.
BS R22542.
BS R39947.
BS R39854.
BS R35816.
BS R26802.
BS R31706.
BS R31708.
BS R41737.
BS R28548.
BS R29689.
BS R29092.
BS R29093.
BS R30620.
BS R30939.
BS R14544.
BS R25018.
BS R26674.
BS R39833.
BS R31611.
BS R14724.
BS R14725.
BS R26758.
BS R39281.
BS R59836.
BS R26793.
BS R09882.
BS R34900.
BS R31188.
BS R39889.
BS R32816.
BS R22860.
BS R56920.
BS R60863.
BS R34120.
BS R36611.
BS R08494.
BS R25195.
BS R38461.
BS R27962.
BS R13178.
BS R14478.
BS R14480.
BS R19623.
BS R19624.
BS R21760.
BS R21763.
BS R21747.
BS R31592.
BS R34765.
BS R31616.
BS R33593.
BS R05017.
BS R05020.
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DR TRANSPATH: MO000007834.
DR UniProtKB: P17535;
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RN [1]; RE0003225.
RX PUBMED: 1313772.
RA Li L., Chambard J. C., Karin M., Olson E. N.
RT Fos and Jun repress transcriptional activation by myogenin and MyoD: the amino terminus of Jun can mediate repression
RL Genes Dev. 6:676-689 (1992).
RN [2]; RE0004784.
RX PUBMED: 2112242.
RA Nomura N., Ide M., Sasamoto S., Matsui M., Date T., Ishizaki R.
RT Isolation of human cDNA clones of jun-related genes, jun-B and jun-D
RL Nucleic Acids Res. 18:3047-3048 (1990).
RN [3]; RE0004786.
RX PUBMED: 1903194.
RA Berger I., Shaul Y.
RT Structure and function of human jun-D
RL Oncogene 6:561-566 (1991).
RN [4]; RE0004788.
RX PUBMED: 8415709.
RA Kameda T., Akahori A., Sonobe M. H., Suzuki T., Endo T., Iba H.
RT JunD mutants with spontaneously acquired transforming potential have enhanced transactivating activity in combination with Fra-2
RL Proc. Natl. Acad. Sci. USA 90:9369-9373 (1993).
RN [5]; RE0013940.
RX PUBMED: 10454570.
RA Cirillo G., Casalino L., Vallone D., Caracciolo A., De Cesare D., Verde P.
RT Role of distinct mitogen-activated protein kinase pathways and cooperation between Ets-2, ATF-2, and Jun family members in human urokinase-type plasminogen activator gene induction by interleukin-1 and tetradecanoyl phorbol acetate
RL Mol. Cell. Biol. 19:6340-6252 (1999).
RN [6]; RE0016689.
RX PUBMED: 7648395.
RA Bassuk A. G., Leiden J. M.
RT A direct physical association between ETS and AP-1 transcription factors in normal human T cells.
RL Immunity 3:223-237 (1995).
RN [7]; RE0034082.
RX PUBMED: 11266514.
RA Watanabe K., Kessler C. A., Bachurski C. J., Kanda Y., Richardson B. D., Stanek J., Handwerger S., Brar A. K.
RT Identification of a decidua-specific enhancer on the human prolactin gene with two critical activator protein 1 (AP-1) binding sites.
RL Mol. Endocrinol. 15:638-53 (2001).
RN [8]; RE0048037.
RX PUBMED: 12080089.
RA Hu Y. F., Li R.
RT JunB potentiates function of BRCA1 activation domain 1 (AD1) through a coiled-coil-mediated interaction.
RL Genes Dev. 16:1509-1517 (2002).
RN [9]; RE0055188.
RX PUBMED: 17921324.
RA Cortez D. M., Feldman M. D., Mummidi S., Valente A. J., Steffensen B., Vincenti M., Barnes J. L., Chandrasekar B.
RT IL-17 stimulates MMP-1 expression in primary human cardiac fibroblasts via p38 MAPK- and ERK1/2-dependent C/EBP-beta, NF-kappaB, and AP-1 activation.
RL Am. J. Physiol. Heart Circ. Physiol. 293:H3356-65 (2007).
RN [10]; RE0066649.
RX PUBMED: 16984917.
RA Byun H. J., Hong I. K., Kim E., Jin Y. J., Jeoung D. I., Hahn J. H., Kim Y. M., Park S. H., Lee H.
RT A splice variant of CD99 increases motility and MMP-9 expression of human breast cancer cells through the AKT-, ERK-, and JNK-dependent AP-1 activation signaling pathways.
RL J. Biol. Chem. 281:34833-34847 (2006).
RN [11]; RE0066800.
RX PUBMED: 20220142.
RA Por E., Byun H. J., Lee E. J., Lim J. H., Jung S. Y., Park I., Kim Y. M., Jeoung D. I., Lee H.
RT The cancer/testis antigen CAGE with oncogenic potential stimulates cell proliferation by up-regulating cyclins D1 and E in an AP-1- and E2F-dependent manner.
RL J. Biol. Chem. 285:14475-14485 (2010).
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