TRANSFAC FACTOR TABLE, Release 2017.2 - public - 2017-06-30, (C) QIAGEN

AC T01443 XX ID T01443 XX DT 10.04.1995 (created); ewi. DT 23.02.2016 (updated); sup. CO Copyright (C), QIAGEN. XX FA Nrf2 XX SY NF-E2-related factor 2; NFE2L2; nuclear factor, erythroid derived 2, like 2. XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; primates XX GE G004136 NFE2L2; HGNC: NFE2L2. XX HO CNC (D. melanogaster). XX CL C0008; bZIP; XX SF the N-terminal part of the molecule does not exhibit significant homology with other members of the NF-E2 family [1]; SF DNA-binding as heterodimer with small Maf proteins [2]; XX CP tBHQ-treated HepG2/GFP-B [4]; K562 cells treated with t-BHQ (tert-butylhydroquinone) [11]; KCL22 and KCL22/SR [16]. EX blood,basophil granulocyte,Circulatory System & Hematopoietic System,adult; detectable; Northern blot; mRNA (poly-A); [2]. EX blood,eosinophil granulocyte,Circulatory System & Hematopoietic System,adult; high; Northern blot; mRNA (poly-A); [2]. EX blood,lymphocyte,Circulatory System & Hematopoietic System,adult; high; Northern blot; mRNA (poly-A); [2]. EX blood,monocyte,Circulatory System & Hematopoietic System,adult; high; Northern blot; mRNA (poly-A); [2]. EX blood,neutrophil granulocyte,Circulatory System & Hematopoietic System,adult; high; Northern blot; mRNA (poly-A); [2]. EX colon,,,adult; high; Northern blot; mRNA (poly-A); [2]. EX ovary (right and left),,,adult; high; Northern blot; mRNA (poly-A); [2]. EX prostate gland,,,adult; high; Northern blot; mRNA (poly-A); [2]. EX small intestine,,,adult; high; Northern blot; mRNA (poly-A); [2]. EX spleen,,,adult; high; Northern blot; mRNA (poly-A); [2]. EX testis (right and left),,,adult; high; Northern blot; mRNA (poly-A); [2]. EX thymus,,,adult; high; Northern blot; mRNA (poly-A); [2]. XX FF activated by LPS in monocytic and THP-1 cells [9]; FF Nrf2 silencing leads to decrease in GSH activity and increase in ROS and TBARS levels in E47 cells treated with arachidonic acid [10]; FF Activated by DETA-NO treatment in SH-Sy-5y cells [12]; FF Protects from arachidonic acid and BSO induced CYP2E1 mediated toxicity in E47 cells [10]; XX IN T02872 beta-catenin; human, Homo sapiens. IN T30638 BRD4; human, Homo sapiens. IN T08461 c-Jun; human, Homo sapiens. IN T01978 JunD; human, Homo sapiens. IN T04870 MafG; human, Homo sapiens. IN T09572 MafG; human, Homo sapiens. IN T04874 MafK; human, Homo sapiens. IN T09555 MafK; human, Homo sapiens. IN T01440 NF-E2p45; human, Homo sapiens. IN T02529 PPARgamma1; mouse, Mus musculus. IN T01345 RXR-alpha; human, Homo sapiens. XX MX M07296 V$MAF_Q4. MX M00983 V$MAF_Q6_01. MX M02263 V$NFE2L2_01. MX M07610 V$NRF2_Q3. MX M00821 V$NRF2_Q4. MX M07265 V$NRF2_Q4_01. MX M03835 V$NRF2_Q6. XX BS R05653. BS R22793. BS R34205. BS R62522. BS R62524. BS R37178. BS R40244. BS R20687. BS R66682. BS R60779. BS R65372. BS R73240. BS R73233. BS R29050. BS R55834. BS R41929. BS R37227. BS R57984. BS R57986. BS R37761. BS R63815. BS R35942. BS R68053. BS R35445. BS R71779. BS R22554. BS R22708. BS R61720. BS R71364. BS R22541. BS R22710. BS R64063. BS R22942. BS R33391. BS R19568. BS R21361. BS R22644. BS R32838. BS R34941. BS R57419. BS R62734. BS R71622. BS R71624. BS R71978. BS R25817. BS R64469. BS R64468. BS R66088. BS R66089. BS R40548. BS R22532. BS R37901. BS R70444. BS R70445. BS R70446. BS R70448. BS R64614. BS R60256. BS R60259. BS R66130. BS R29013. BS R26035. BS R41928. BS R71776. BS R71777. BS R60862. BS R69115. BS R69116. BS R73224. BS R63140. BS R63142. BS R63143. BS R63145. BS R40564. BS R34091. BS R34129. BS R34138. BS R72105. BS R72107. BS R72108. BS R72110. BS R72111. BS R72112. BS R21769. BS R21770. BS R22552. BS R13590. BS R14173. BS R23007. BS R37777. XX DR TRANSPATH: MO000025668. DR UniProtKB: Q16236; XX RN [1]; RE0003531. RX PUBMED: 7937919. RA Moi P., Chan K., Asunis I., Cao A., Kan Y. W. RT Isolation of NF-E2-related factor 2 (Nrf2), a NF-E2-like basic leucine zipper transcriptional activator that binds to the tandem NF-E2/AP1 repeat of the beta-globin locus control region RL Proc. Natl. Acad. Sci. USA 91:9926-9930 (1994). RN [2]; RE0017136. RX PUBMED: 9195958. RA Marini M. G., Chan K., Casula L., Kan Y. W., Cao A., Moi P. RT hMAF, a small human transcription factor that heterodimerizes specifically with Nrf1 and Nrf2 RL J. Biol. Chem. 272:16490-16497 (1997). RN [3]; RE0017304. RX PUBMED: 10930400. RA Ikeda Y., Sugawara A., Taniyama Y., Uruno A., Igarashi K., Arima S., Ito S., Takeuchi K. RT Suppression of rat thromboxane synthase gene transcription by peroxisome proliferator-activated receptor gamma in macrophages via an interaction with NRF2 RL J. Biol. Chem. 275:33142-33150 (2000). RN [4]; RE0017305. RX PUBMED: 11708801. RA Zhu M., Fahl W. E. RT Functional characterization of transcription regulators that interact with the electrophile response element RL Biochem. Biophys. Res. Commun. 289:212-219 (2001). RN [5]; RE0048287. RX PUBMED: 12805554. RA Newman J. R., Keating A. E. RT Comprehensive identification of human bZIP interactions with coiled-coil arrays. RL Science 300:2097-2101 (2003). RN [6]; RE0050213. RX PUBMED: 15601839. RA Furukawa M., Xiong Y. RT BTB protein Keap1 targets antioxidant transcription factor Nrf2 for ubiquitination by the Cullin 3-Roc1 ligase. RL Mol. Cell. Biol. 25:162-171 (2005). RN [7]; RE0051048. RX PUBMED: 17636022. RA Sun Z., Zhang S., Chan J. Y., Zhang D. D. RT Keap1 controls postinduction repression of the Nrf2-mediated antioxidant response by escorting nuclear export of Nrf2. RL Mol. Cell. Biol. 27:6334-6349 (2007). RN [8]; RE0051053. RX PUBMED: 15367669. RA Cullinan S. B., Gordan J. D., Jin J., Harper J. W., Diehl J. A. RT The Keap1-BTB protein is an adaptor that bridges Nrf2 to a Cul3-based E3 ligase: oxidative stress sensing by a Cul3-Keap1 ligase. RL Mol. Cell. Biol. 24:8477-8486 (2004). RN [9]; RE0051271. RX PUBMED: 16177082. RA Rushworth S. A., Chen X. L., Mackman N., Ogborne R. M., O'Connell M. A. RT Lipopolysaccharide-induced heme oxygenase-1 expression in human monocytic cells is mediated via Nrf2 and protein kinase C. RL J. Immunol. 175:4408-4415 (2005). RN [10]; RE0051584. RX PUBMED: 16551616. RA Gong P., Cederbaum A. I. RT Transcription factor Nrf2 protects HepG2 cells against CYP2E1 plus arachidonic acid-dependent toxicity. RL J. Biol. Chem. 281:14573-14579 (2006). RN [11]; RE0051628. RX PUBMED: 15640523. RA Arinze I. J., Kawai Y. RT Transcriptional activation of the human Galphai2 gene promoter through nuclear factor-kappaB and antioxidant response elements. RL J. Biol. Chem. 280:9786-9795 (2005). RN [12]; RE0051784. RX PUBMED: 14985350. RA Dhakshinamoorthy S., Porter A. G. RT Nitric oxide-induced transcriptional up-regulation of protective genes by Nrf2 via the antioxidant response element counteracts apoptosis of neuroblastoma cells. RL J. Biol. Chem. 279:20096-20107 (2004). RN [13]; RE0052113. RX PUBMED: 17875699. RA Seng S., Avraham H. K., Jiang S., Yang S., Sekine M., Kimelman N., Li H., Avraham S. RT The nuclear matrix protein, NRP/B, enhances Nrf2-mediated oxidative stress responses in breast cancer cells. RL Cancer Res. 67:8596-8604 (2007). RN [14]; RE0052140. RX PUBMED: 16923960. RA Zhang J., Ohta T., Maruyama A., Hosoya T., Nishikawa K., Maher J. M., Shibahara S., Itoh K., Yamamoto M. RT BRG1 interacts with Nrf2 to selectively mediate HO-1 induction in response to oxidative stress. RL Mol. Cell. Biol. 26:7942-7952 (2006). RN [15]; RE0052144. RX PUBMED: 17512459. RA Pi J., Bai Y., Reece J. M., Williams J., Liu D., Freeman M. L., Fahl W. E., Shugar D., Liu J., Qu W., Collins S., Waalkes M. P. RT Molecular mechanism of human Nrf2 activation and degradation: role of sequential phosphorylation by protein kinase CK2. RL Free Radic. Biol. Med. 42:1797-1806 (2007). RN [16]; RE0052521. RX PUBMED: 15050748. RA Tarumoto T., Nagai T., Ohmine K., Miyoshi T., Nakamura M., Kondo T., Mitsugi K., Nakano S., Muroi K., Komatsu N., Ozawa K. RT Ascorbic acid restores sensitivity to imatinib via suppression of Nrf2-dependent gene expression in the imatinib-resistant cell line. RL Exp. Hematol. 32:375-381 (2004). RN [17]; RE0066126. RX PUBMED: 20053997. RA Kalthoff S., Ehmer U., Freiberg N., Manns M. P., Strassburg C. P. RT Interaction between oxidative stress sensor Nrf2 and xenobiotic-activated aryl hydrocarbon receptor in the regulation of the human phase II detoxifying UDP-glucuronosyltransferase 1A10. RL J. Biol. Chem. 285:5993-6002 (2010). RN [18]; RE0068188. RX PUBMED: 20173742. RA Komatsu M., Kurokawa H., Waguri S., Taguchi K., Kobayashi A., Ichimura Y., Sou Y. S., Ueno I., Sakamoto A., Tong K. I., Kim M., Nishito Y., Iemura S., Natsume T., Ueno T., Kominami E., Motohashi H., Tanaka K., Yamamoto M. RT The selective autophagy substrate p62 activates the stress responsive transcription factor Nrf2 through inactivation of Keap1. RL Nat. Cell Biol. 12:213-223 (2010). XX //