AC T02529
XX
ID T02529
XX
DT 02.12.1998 (created); ewi.
DT 13.02.2014 (updated); pro.
CO Copyright (C), QIAGEN.
XX
FA PPARgamma1
XX
SY NR1C3; Nuclear receptor subfamily 1 group C member 3; peroxisome proliferator-activated receptor gamma; PPAR-gamma; PPARG; PPARgamma.
XX
OS mouse, Mus musculus
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae
XX
GE G004880 Pparg.
XX
CL C0002; CC (rec); 2.1.2.5.3.1.
XX
SZ 475 AA; 54.5 kDa (cDNA) (calc.).
XX
SQ MVDTEMPFWPTNFGISSVDLSVMEDHSHSFDIKPFTTVDFSSISAPHYEDIPFTRADPMV
SQ ADYKYDLKLQEYQSAIKVEPASPPYYSEKTQLYNRPHEEPSNSLMAIECRVCGDKASGFH
SQ YGVHACEGCKGFFRRTIRLKLIYDRCDLNCRIHKKSRNKCQYCRFQKCLAVGMSHNAIRF
SQ GRMPQAEKEKLLAEISSDIDQLNPESADLRALAKHLYDSYIKSFPLTKAKARAILTGKTT
SQ DKSPFVIYDMNSLMMGEDKIKFKHITPLQEQSKEVAIRIFQGCQFRSVEAVQEITEYAKN
SQ IPGFINLDLNDQVTLLKYGVHEIIYTMLASLMNKDGVLISEGQGFMTREFLKSLRKPFGD
SQ FMEPKFEFAVKFNALELDDSDLAIFIAVIILSGDRPGLLNVKPIEDIQDNLLQALELQLK
SQ LNHPESSQLFAKVLQKMTDLRQIVTEHVQLLHVIKKTETDMSLHPLLQEIYKDLY
XX
SC Swiss-Prot#P37238-2
XX
FT 13 350 
PF00478; IMP dehydrogenase / GMP reductase domai.
FT 80 83 
consensus MAP kinase site [7].
FT 106 176 
SM00399; c4gold.
FT 106 180 
PS51030; NUCLEAR_REC_DBD_2.
FT 107 181 
PF00105; Zinc finger, C4 type (two domains).
FT 108 173 
DNA-binding domain [8].
FT 280 475 
ligand-binding domain [8].
FT 285 444 
SM00430; holi.
FT 288 470 
PF00104; Ligand-binding domain of nuclear hormon.
XX
SF one of two known isoforms produced from alternative promoters and by alternative splicing, see mouse PPAR-gamma T05347 and mouse PPAR-gamma2 T05332 [3];
XX
FF activator as a heterodimer with RXR-alpha;
FF member of the steroid hormone receptor superfamily;
FF expression is under control of C/EBPbeta, probably synergizing with C/EBPdelta, and of glucocorticoids [2];
XX
IN T17544 NFATc1b; mouse, Mus musculus.
IN T10936 Nrf2-isoform2; human, Homo sapiens.
IN T01443 Nrf2; human, Homo sapiens.
IN T02529 PPARgamma1; mouse, Mus musculus.
IN T01345 RXR-alpha; human, Homo sapiens.
IN T21552 SRC-1; Mammalia.
XX
MX M00763 V$PPARDR1_Q2.
MX M02262 V$PPARGRXRA_01.
MX M00512 V$PPARG_01.
MX M00515 V$PPARG_02.
MX M00528 V$PPARG_03.
MX M01270 V$PPARG_Q6.
XX
BS R11480.
BS R11481.
BS R11482.
BS R11483.
BS R11484.
BS R11485.
BS R11486.
BS R11487.
BS R11488.
BS R11489.
BS R11585.
BS R11490.
BS R11491.
BS R11492.
BS R11493.
BS R11494.
BS R11495.
BS R11496.
BS R11497.
BS R11498.
BS R11499.
BS R11500.
BS R11501.
BS R11502.
BS R11503.
BS R11504.
BS R11505.
BS R11506.
BS R11507.
BS R11508.
BS R11509.
BS R11510.
BS R11511.
BS R11512.
BS R11513.
BS R11514.
BS R11515.
BS R11516.
BS R11517.
BS R11518.
BS R11519.
BS R11520.
BS R11521.
BS R11522.
BS R11523.
BS R11524.
BS R11525.
BS R11526.
BS R11527.
BS R11528.
BS R11529.
BS R11530.
BS R11531.
BS R11532.
BS R11533.
BS R11534.
BS R11535.
BS R11536.
BS R11537.
BS R11538.
BS R11539.
BS R11540.
BS R11541.
BS R11542.
BS R11543.
BS R11544.
BS R11545.
BS R11546.
BS R11547.
BS R11548.
BS R11549.
BS R11550.
BS R11551.
BS R11555.
BS R11556.
BS R11557.
BS R11558.
BS R11559.
BS R11560.
BS R11561.
BS R11562.
BS R11563.
BS R11564.
BS R11565.
BS R11566.
BS R11567.
BS R11568.
BS R11572.
BS R11573.
BS R11574.
BS R11575.
BS R11576.
BS R11577.
BS R11578.
BS R11579.
BS R11580.
BS R11581.
BS R11582.
BS R11583.
BS R11584.
BS R27483.
BS R60266.
BS R12750.
XX
DR TRANSPATH: MO000026509.
DR EMBL: S79403;
DR EMBL: U01664;
DR EMBL: U01841;
DR EMBL: U09138;
DR EMBL: U10374;
DR UniProtKB: P37238-2; PPARG_MOUSE.
XX
RN [1]; RE0007068.
RX PUBMED: 8240342.
RA Chen F., Law S. W., O'Malley B. W.
RT Identification of two mPPAR related receptors and evidence for the existence of five subfamily members
RL Biochem. Biophys. Res. Commun. 196:671-677 (1993).
RN [2]; RE0007069.
RX PUBMED: 8754811.
RA Wu Z., Bucher N. L. R., Farmer S. R.
RT Induction of peroxisome proliferator-activated receptor gamma during the conversion of 3T3 fibroblasts into adipocytes is mediated by C/EBPbeta, C/EBPdelta, and glucocorticoids
RL Mol. Cell. Biol. 16:4128-4136 (1996).
RN [3]; RE0011113.
RX PUBMED: 7644514.
RA Zhu Y., Qi C., Korenberg J. R., Chen X.-N., Noya D., Rao M. S., Reddy J. K.
RT Structural organization of mouse peroxisome proliferator-activated receptor gamma (mPPARgamma) gene: Alternative promoter use and different splicing yield two mPPARgamma isoforms
RL Proc. Natl. Acad. Sci. USA 92:7921-7929 (1995).
RN [4]; RE0011203.
RX PUBMED: 8521497.
RA Forman B.M., Tontonoz P., Chen J., Brun R. P., Spiegelman B. M., Evans R. M.
RT 15-Deoxy-delta12,14-prostaglandin J2 is a ligand for the adipocyte determination factor PPARgamma
RL Cell 83:803-812 (1995).
RN [5]; RE0011205.
RX PUBMED: 8521498.
RA Kliewer S. A., Lenhard J. M., Willson T. M., Patel I., Morris D. C., Lehmann J. M.
RT A prostaglandin J2 metabolite binds peroxisome proliferator-activated receptor gamma and promotes adipocyte differentiation
RL Cell 83:813-819 (1995).
RN [6]; RE0017304.
RX PUBMED: 10930400.
RA Ikeda Y., Sugawara A., Taniyama Y., Uruno A., Igarashi K., Arima S., Ito S., Takeuchi K.
RT Suppression of rat thromboxane synthase gene transcription by peroxisome proliferator-activated receptor gamma in macrophages via an interaction with NRF2
RL J. Biol. Chem. 275:33142-33150 (2000).
RN [7]; RE0018160.
RX PUBMED: 9030579.
RA Adams M., Reginato M. J., Shao D., Lazar M. A., Chatterjee V. K.
RT Transcriptional activation by peroxisome proliferator-activated receptor gamma is inhibited by phosphorylation at a consensus mitogen-activated protein kinase site.
RL J. Biol. Chem. 272:5128-5132 (1997).
RN [8]; RE0018281.
RX PUBMED: 8041794.
RA Kliewer S. A., Forman B. M., Blumberg B., Ong E. S., Borgmeyer U., Mangelsdorf D. J., Umesono K., Evans R. M.
RT Differential expression and activation of a family of murine peroxisome proliferator-activated receptors.
RL Proc. Natl. Acad. Sci. USA 91:7355-7359 (1994).
RN [9]; RE0034867.
RX PUBMED: 15367687.
RA Akaike M., Che W., Marmarosh N. L., Ohta S., Osawa M., Ding B., Berk B. C., Yan C., Abe J.
RT The hinge-helix 1 region of peroxisome proliferator-activated receptor gamma1 (PPARgamma1) mediates interaction with extracellular signal-regulated kinase 5 and PPARgamma1 transcriptional activation: involvement in flow-induced PPARgamma activation in endothelial cells.
RL Mol. Cell. Biol. 24:8691-704 (2004).
RN [10]; RE0038010.
RX PUBMED: 10347167.
RA Heinlein C. A., Ting H. J., Yeh S., Chang C.
RT Identification of ARA70 as a ligand-enhanced coactivator for the peroxisome proliferator-activated receptor gamma
RL J. Biol. Chem. 274:16147-52 (1999).
RN [11]; RE0047835.
RX PUBMED: 14573767.
RA Chung S. W., Kang B. Y., Kim T. S.
RT Inhibition of interleukin-4 production in CD4+ T cells by peroxisome proliferator-activated receptor-gamma (PPAR-gamma) ligands: involvement of physical association between PPAR-gamma and the nuclear factor of activated T cells transcription factor.
RL Mol. Pharmacol. 64:1169-1179 (2003).
RN [12]; RE0050070.
RX PUBMED: 7592593.
RA Yu K., Bayona W., Kallen C. B., Harding H. P., Ravera C. P., McMahon G., Brown M., Lazar M. A.
RT Differential activation of peroxisome proliferator-activated receptors by eicosanoids.
RL J. Biol. Chem. 270:23975-23983 (1995).
RN [13]; RE0050168.
RX PUBMED: 16267130.
RA Liu Y., Zhang Y., Schmelzer K., Lee T. S., Fang X., Zhu Y., Spector A. A., Gill S., Morisseau C., Hammock B. D., Shyy J. Y.
RT The antiinflammatory effect of laminar flow: the role of PPARgamma, epoxyeicosatrienoic acids, and soluble epoxide hydrolase.
RL Proc. Natl. Acad. Sci. USA 102:16747-16752 (2005).
RN [14]; RE0050188.
RX PUBMED: 17164145.
RA Fang X., Dillon J. S., Hu S., Harmon S. D., Yao J., Anjaiah S., Falck J. R., Spector A. A.
RT 20-carboxy-arachidonic acid is a dual activator of peroxisome proliferator-activated receptors alpha and gamma.
RL Prostaglandins Other Lipid Mediat. 82:175-184 (2007).
RN [15]; RE0050338.
RX PUBMED: 11889173.
RA Schild R. L., Schaiff W. T., Carlson M. G., Cronbach E. J., Nelson D. M., Sadovsky Y.
RT The activity of PPAR gamma in primary human trophoblasts is enhanced by oxidized lipids.
RL J. Clin. Endocrinol. Metab. 87:1105-1110 (2002).
RN [16]; RE0050364.
RX PUBMED: 12573447.
RA Soderstrom M., Wigren J., Surapureddi S., Glass C. K., Hammarstrom S.
RT Novel prostaglandin D(2)-derived activators of peroxisome proliferator-activated receptor-gamma are formed in macrophage cell cultures.
RL Biochim. Biophys. Acta 1631:35-41 (2003).
RN [17]; RE0050933.
RX PUBMED: 16127449.
RA Pascual G., Fong A. L., Ogawa S., Gamliel A., Li A. C., Perissi V., Rose D. W., Willson T. M., Rosenfeld M. G., Glass C. K.
RT A SUMOylation-dependent pathway mediates transrepression of inflammatory response genes by PPAR-gamma.
RL Nature 437:759-763 (2005).
XX
//