AC T04870
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ID T04870
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DT 19.11.2001 (created); rge.
DT 26.01.2015 (updated); pro.
CO Copyright (C), QIAGEN.
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FA MafG
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SY basic-leucine zipper transcription factor MafG; hMAF.
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OS human, Homo sapiens
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; primates
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GE G002904 MAFG; HGNC: MAFG.
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CL C0008; bZIP; 1.1.3.2.2.
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SF hMaf is able to homodimerize in solution and to bind to the NFE2 tandem repeat [1];
SF can form high affinity heterodimers with Nrf1 and Nrf2, two members of the NFE2/CNC-bZip family [1];
SF conflicting results of ability to heterodimerize with p45-NFE2 [1] [2];
SF heterodimers of hMaf with Nrf1 and Nrf2 bind to the same NFE2 site and stimulate the activity of a gamma-promoter reporter [1];
SF the association into homodimers that is induced by overexpression of hMAF inhibits the activity of a gamma-promoter reporter construct by keeping the heterodimers from binding to their recognition sites [1];
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CP adult: heart, brain, placenta, liver, liver, skeletal muscle, pancreas, spleen, thymus, prostate, testis, uterus, small intestine, colon; fetal: brain, lung, liver, kidney [2].
CN adult: lung, kidney, leukocytes [2].
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FF Induced by PDTC and beta- NF in HepG2 cells [5];
FF hMAF may account for the modulation in the activity of the genes that bear NFE2 recognition sites [1];
FF p45:MafG heterodimer plays a role in the regulation of erythropoiesis [2];
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IN T00133 c-Jun; human, Homo sapiens.
IN T04870 MafG; human, Homo sapiens.
IN T18835 Mi2-alpha; human, Homo sapiens.
IN T01440 NF-E2p45; human, Homo sapiens.
IN T01442 Nfe2l1-isoform2; human, Homo sapiens.
IN T09066 Nfe2l1; human, Homo sapiens.
IN T01443 Nrf2; human, Homo sapiens.
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MX M07048 V$MAFG_Q3.
MX M07296 V$MAF_Q4.
MX M00983 V$MAF_Q6_01.
MX M00284 V$TCF11MAFG_01.
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BS R22556.
BS R65535.
BS R22545.
BS R38717.
BS R65533.
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DR TRANSPATH: MO000028667.
DR UniProtKB: O15525;
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RN [1]; RE0017136.
RX PUBMED: 9195958.
RA Marini M. G., Chan K., Casula L., Kan Y. W., Cao A., Moi P.
RT hMAF, a small human transcription factor that heterodimerizes specifically with Nrf1 and Nrf2
RL J. Biol. Chem. 272:16490-16497 (1997).
RN [2]; RE0017137.
RX PUBMED: 9166829.
RA Blank V., Kim M. J., Andrews N. C.
RT Human MafG is a functional partner for p45 NF-E2 in activating globin gene expression
RL Blood 89:3925-3935 (1997).
RN [3]; RE0017138.
RX PUBMED: 9286713.
RA Blank V., Knoll J. H., Andrews N. C.
RT Molecular characterization and localization of the human MAFG gene
RL Genomics 44:147-149 (1997).
RN [4]; RE0017139.
RX PUBMED: 9150357.
RA Toki T., Itoh J., Kitazawa J., Arai K., Hatakeyama K., Akasaka J., Igarashi K., Nomura N., Yokoyama M., Yamamoto M., Ito E.
RT Human small Maf proteins form heterodimers with CNC family transcription factors and recognize the NF-E2 motif
RL Oncogene 14:1901-1910 (1997).
RN [5]; RE0027756.
RX PUBMED: 10559251.
RA Wild A. C., Moinova H. R., Mulcahy R. T.
RT Regulation of gamma-glutamylcysteine synthetase subunit gene expression by the transcription factor Nrf2.
RL J. Biol. Chem. 274:33627-36 (1999).
RN [6]; RE0063261.
RX PUBMED: 16169070.
RA Stelzl U., Worm U., Lalowski M., Haenig C., Brembeck F. H., Goehler H., Stroedicke M., Zenkner M., Schoenherr A., Koeppen S., Timm J., Mintzlaff S., Abraham C., Bock N., Kietzmann S., Goedde A., Toksoz E., Droege A., Krobitsch S., Korn B., Birchmeier W., Lehrach H., Wanker E. E.
RT A human protein-protein interaction network: a resource for annotating the proteome.
RL Cell 122:957-968 (2005).
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