AC T01442
XX
ID T01442
XX
DT 10.04.1995 (created); ewi.
DT 24.09.2009 (updated); din.
CO Copyright (C), QIAGEN.
XX
FA Nfe2l1-isoform2
XX
SY NF-E2-related factor 1; NRF1; Nrf1-2.
XX
OS human, Homo sapiens
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; primates
XX
GE G004137 NFE2L1; HGNC: NFE2L1.
XX
HO Cnc (D. melanogaster).
XX
CL C0008; bZIP; 1.1.1.2.2.2.
XX
SZ 742 AA; 81.5 kDa (cDNA) (calc.), 110 kDa (SDS)
XX
SQ MLSLKKYLTEGLLQFTILLSLIGVRVDVDTYLTSQLPPLREIILGPSSAYTQTQFHNLRN
SQ TLDGYGIHPKSIDLDNYFTARRLLSQVRALDRFQVPTTEVNAWLVHRDPEGSVSGSQPNS
SQ GLALESSSGLQDVTGPDNGVRESETEQGFGEDLEDLGAVAPPVSGDLTKEDIDLIDILWR
SQ QDIDLGAGREVFDYSHRQKEQDVEKELRDGGEQDTWAGEGAEALARNLLVDGETGESFPA
SQ QFPADISSITEAVPSESEPPALQNNLLSPLLTGTESPFDLEQQWQDLMSIMEMQAMEVNT
SQ SASEILYSAPPGDPLSTNYSLAPNTPINQNVSLHQASLGGCSQDFLLFSPEVESLPVASS
SQ STLLPLAPSNSTSLNSTFGSTNLTGLFFPPQLNGTANDTAGPELPDPLGGLLDEAMLDEI
SQ SLMDLAIEEGFNPVQASQLEEEFDSDSGLSLDSSHSPSSLSSSEGSSSSSSSSSSSSSSA
SQ SSSASSSFSEEGAVGYSSDSETLDLEEAEGAVGYQPEYSKFCRMSYQDPAQLSCLPYLEH
SQ VGHNHTYNMAPSALDSADLPPPSALKKGSKEKQADFLDKQMSRDEHRARAMKIPFTNDKI
SQ INLPVEEFNELLSKYQLSEAQLSLIRDIRRRGKNKMAAQNCRKRKLDTILNLERDVEDLQ
SQ RDKARLLREKVEFLRSLRQMKQKVQSLYQEVFGRLRDENGRPYSPSQYALQYAGDGSVLL
SQ IPRTMADQQARRQERKPKDRRK
XX
SC translated from EMBL #L24123
XX
FT 6 673 
PF00478; IMP dehydrogenase / GMP reductase domain.
FT 296 296 
alternative translation initiation [2].
FT 622 686 
PF00170; bZIP transcription factor.
FT 622 686 
SM00338; brlzneu.
FT 624 687 
PS50217; BZIP.
XX
SF bZIP domain is similar to that of AP-1 components;
SF in K562 cells, only the short version (LCR-F1) is found [2];
SF DNA-binding as heterodimer with small Maf proteins [4];
XX
EX blood,basophil granulocyte,Circulatory System & Hematopoietic System,adult; high; Northern blot; mRNA (poly-A); [4].
EX blood,eosinophil granulocyte,Circulatory System & Hematopoietic System,adult; detectable; Northern blot; mRNA (poly-A); [4].
EX blood,lymphocyte,Circulatory System & Hematopoietic System,adult; detectable; Northern blot; mRNA (poly-A); [4].
EX blood,monocyte,Circulatory System & Hematopoietic System,adult; detectable; Northern blot; mRNA (poly-A); [4].
EX blood,neutrophil granulocyte,Circulatory System & Hematopoietic System,adult; detectable; Northern blot; mRNA (poly-A); [4].
EX colon,,,adult; high; Northern blot; mRNA (poly-A); [4].
EX ovary (right and left),,,adult; high; Northern blot; mRNA (poly-A); [4].
EX prostate gland,,,adult; high; Northern blot; mRNA (poly-A); [4].
EX small intestine,,,adult; detectable; Northern blot; mRNA (poly-A); [4].
EX spleen,,,adult; high; Northern blot; mRNA (poly-A); [4].
EX testis (right and left),,,adult; high; Northern blot; mRNA (poly-A); [4].
EX thymus,,,adult; high; Northern blot; mRNA (poly-A); [4].
XX
FF potent transcriptional activator through NF-E2/AP-1 sites [2];
XX
IN T04870 MafG; human, Homo sapiens.
IN T04874 MafK; human, Homo sapiens.
XX
MX M07296 V$MAF_Q4.
MX M00983 V$MAF_Q6_01.
MX M00284 V$TCF11MAFG_01.
MX M00285 V$TCF11_01.
XX
BS R02420.
XX
DR TRANSPATH: MO000025667.
DR EMBL: L24123;
DR UniProtKB: Q14494-2;
XX
RN [1]; RE0003529.
RX PUBMED: 8036168.
RA Caterina J. J., Donze D., Sun C.-W., Ciavatta D. J., Townes T. M.
RT Cloning and functional characterization of LCR-F1: a bZIP transcription factor that activates erythroid-specific, human globin gene expression
RL Nucleic Acids Res. 22:2383- 2391 (1994).
RN [2]; RE0003530.
RX PUBMED: 8248256.
RA Chan J. Y., Han X.-L., Kan Y. W.
RT Cloning of Nrf1, an NF-E2-related transcription factor, by genetic selection in yeast
RL Proc. Natl. Acad. Sci. USA 90:11371-11375 (1993).
RN [3]; RE0006838.
RX PUBMED: 9421508.
RA Johnsen O., Murphy P., Prydz H., Kolsto A.-B.
RT Interaction of the CNC-bZIP factor TCF11/LCR-F1/Nrf1 with MafG: binding-site selection and regulation of transcription
RL Nucleic Acids Res. 26:512-520 (1998).
RN [4]; RE0017136.
RX PUBMED: 9195958.
RA Marini M. G., Chan K., Casula L., Kan Y. W., Cao A., Moi P.
RT hMAF, a small human transcription factor that heterodimerizes specifically with Nrf1 and Nrf2
RL J. Biol. Chem. 272:16490-16497 (1997).
XX
//