AC T01113
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ID T01113
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DT 15.03.1994 (created); ewi.
DT 02.11.2015 (updated); sla.
CO Copyright (C), QIAGEN.
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FA Elf-1
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SY E74-like factor 1; Elf-1; ETS-related transcription factor ELF-1.
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OS human, Homo sapiens
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; primates
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GE G002978 ELF1; HGNC: Elf1.
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CL C0016; ETS; 3.5.2.3.1.
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SF some similarity with E74 (Drosophila) T00208, T00210;
SF probably has two shorter splice isoforms similar to rat ortholog T05014 [7];
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CP coexpressed with NERF T05039 in various tissues, including spleen and thymus [8]; high expression in the immune system and in pancreas [8] [8].
EX blood,basophil granulocyte,Circulatory System & Hematopoietic System,adult; high; Northern blot; mRNA (poly-A); [8].
EX blood,eosinophil granulocyte,Circulatory System & Hematopoietic System,adult; high; Northern blot; mRNA (poly-A); [8].
EX blood,lymphocyte,Circulatory System & Hematopoietic System,adult; high; Northern blot; mRNA (poly-A); [8].
EX blood,monocyte,Circulatory System & Hematopoietic System,adult; high; Northern blot; mRNA (poly-A); [8].
EX blood,neutrophil granulocyte,Circulatory System & Hematopoietic System,adult; high; Northern blot; mRNA (poly-A); [8].
EX brain,,,adult; very low; Northern blot; mRNA (poly-A); [8].
EX brain,,,fetal; low; Northern blot; mRNA (poly-A); [8].
EX colon,,,adult; medium; Northern blot; mRNA (poly-A); [8].
EX heart,,,adult; medium; Northern blot; mRNA (poly-A); [8].
EX heart,,,fetal; high; Northern blot; mRNA (poly-A); [8].
EX kidney (right and left),,,adult; medium; Northern blot; mRNA (poly-A); [8].
EX kidney (right and left),,,fetal; high; Northern blot; mRNA (poly-A); [8].
EX liver,,,adult; medium; Northern blot; mRNA (poly-A); [8].
EX liver,,,fetal; high; Northern blot; mRNA (poly-A); [8].
EX lung (right and left),,,adult; medium; Northern blot; mRNA (poly-A); [8].
EX lung (right and left),,,fetal; high; Northern blot; mRNA (poly-A); [8].
EX muscles,,,adult; medium; Northern blot; mRNA (poly-A); [8].
EX ovary (right and left),,,adult; medium; Northern blot; mRNA (poly-A); [8].
EX pancreas,,,adult; high; Northern blot; mRNA (poly-A); [8].
EX placenta,,,adult; medium; Northern blot; mRNA (poly-A); [8].
EX prostate gland,,,adult; medium; Northern blot; mRNA (poly-A); [8].
EX small intestine,,,adult; medium; Northern blot; mRNA (poly-A); [8].
EX spleen,,,adult; high; Northern blot; mRNA (poly-A); [8].
EX testis (right and left),,,adult; very low; Northern blot; mRNA (poly-A); [8].
EX thymus,,,adult; high; Northern blot; mRNA (poly-A); [8].
XX
FF activator [8];
FF Elf-1 preferentially associates with underphosphorylated Rb;
FF T cell activation results in phosphorylation of Rb and release of Elf-1 and gives way for Elf-1-dependent transcription;
FF seems to have similar affinities for several ETS DNA binding sites like NERF-1a T05021 [8];
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IN T00123 c-Fos; human, Homo sapiens.
IN T00133 c-Jun; human, Homo sapiens.
IN T08562 CREB1; human, Homo sapiens.
IN T08993 FOSB; human, Homo sapiens.
IN T01462 Fra-1; human, Homo sapiens.
IN T01991 Fra-2; human, Homo sapiens.
IN T09925 GATA-3; human, Homo sapiens.
IN T01977 JunB; human, Homo sapiens.
IN T01978 JunD; human, Homo sapiens.
IN T00593 NF-kappaB1-p50; human, Homo sapiens.
IN T10617 NF-YC; human, Homo sapiens.
IN T10365 NFAT; human, Homo sapiens.
IN T00722 pRb; human, Homo sapiens.
XX
MX M03966 V$ELF1_02.
MX M04714 V$ELF1_03.
MX M07087 V$ELF1_06.
MX M07415 V$ELF1_07.
MX M07417 V$ELF1_Q4.
MX M01266 V$ELF1_Q5.
MX M00746 V$ELF1_Q6.
MX M02053 V$ELF_02.
MX M00771 V$ETS_Q4.
MX M00971 V$ETS_Q6.
XX
BS R19160.
BS R19164.
BS R68512.
BS R68513.
BS R68514.
BS R68515.
BS R68516.
BS R68517.
BS R68518.
BS R68519.
BS R68520.
BS R68521.
BS R68522.
BS R68523.
BS R68524.
BS R68525.
BS R68526.
BS R68527.
BS R68528.
BS R68529.
BS R68530.
BS R68531.
BS R68532.
BS R68533.
BS R68534.
BS R68535.
BS R68536.
BS R68537.
BS R68538.
BS R68539.
BS R68540.
BS R68541.
BS R68542.
BS R68543.
BS R68544.
BS R68545.
BS R68546.
BS R68547.
BS R68548.
BS R68549.
BS R68550.
BS R68551.
BS R68552.
BS R68553.
BS R68554.
BS R68555.
BS R68556.
BS R68557.
BS R68558.
BS R68559.
BS R73989.
BS R22100.
BS R26856.
BS R25476.
BS R25964.
BS R00604.
BS R26656.
BS R24622.
BS R25593.
BS R25594.
BS R22316.
BS R73634.
BS R36309.
BS R14804.
BS R14808.
BS R74052.
BS R28970.
BS R04298.
BS R26679.
BS R73936.
BS R19534.
BS R19535.
BS R19157.
BS R19158.
BS R19161.
BS R39106.
BS R17036.
BS R14156.
BS R27925.
BS R28506.
BS R28509.
BS R26678.
BS R14788.
BS R14789.
BS R69232.
BS R62520.
BS R34619.
BS R04064.
BS R73931.
BS R37119.
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DR TRANSPATH: MO000025410.
DR TRANSCOMPEL: C00081.
DR TRANSCOMPEL: C00118.
DR TRANSCOMPEL: C00133.
DR TRANSCOMPEL: C00139.
DR TRANSCOMPEL: C00234.
DR TRANSCOMPEL: C00314.
DR TRANSCOMPEL: C00541.
DR TRANSCOMPEL: C00610.
DR UniProtKB: P32519;
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RN [1]; RE0002718.
RX PUBMED: 8493578.
RA Wang C.-Y., Petryniak B., Thompson C. B., Kaelin W. G., Leiden J. M.
RT Regulation of the Ets-related transcription factor Elf-1 by binding to the retinoblastoma protein
RL Science 260:1330-1335 (1993).
RN [2]; RE0003086.
RX PUBMED: 1545787.
RA Thompson C. B., Wang C.-Y., Ho I-C., Bohjanen P. R., Petryniak B., June C. H., Miesfeldt S., Zhang L., Nabel G. J., Karpinski B., Leiden J. M.
RT cis-acting sequences required for inducible interleukin-2 enhancer function bind a novel Ets-related protein, Elf-1
RL Mol. Cell. Biol. 12:1043-1053 (1992).
RN [3]; RE0004628.
RX PUBMED: 8441422.
RA Boise L., Petryniak B., Mao X., June C. H., Wang C.-Y., Lindsten T., Bravo R., Kovary K., Leiden J., Thompson C. B.
RT The NFAT-1 DNA binding complex in activated T cells contains Fra-1 and JunB
RL Mol. Cell. Biol. 13:1911-1919 (1993).
RN [4]; RE0005363.
RX PUBMED: 1527846.
RA Leiden J. M., Wang C. Y., Petryniak B., Markovitz D. M., Nabel G. J., Thompson C. B.
RT A novel Ets-related transcription factor, Elf-1, binds to human immunodeficiency virus type 2 regulatory elements that are required for inducible trans activation in T cells
RL J. Virol. 66:5890-5897 (1992).
RN [5]; RE0016682.
RX PUBMED: 9094628.
RA Bassuk A. G., Anandappa R. T., Leiden J. M.
RT Physical interactions between Ets and NF-kappaB/NFAT proteins play an important role in their cooperative activation of the human immunodeficiency virus enhancer in T cells.
RL J. Virol. 71:3563-3573 (1997).
RN [6]; RE0016689.
RX PUBMED: 7648395.
RA Bassuk A. G., Leiden J. M.
RT A direct physical association between ETS and AP-1 transcription factors in normal human T cells.
RL Immunity 3:223-237 (1995).
RN [7]; RE0017450.
RX PUBMED: 11210123.
RA Nishiyama C., Takahashi K., Nishiyama M., Okumura K., Ra C., Ohtake Y., Yokota T.
RT Splice isoforms of transcription factor Elf-1 affecting its regulatory function in transcription-molecular cloning of rat Elf-1.
RL Biosci. Biotechnol. Biochem. 64:2601-2607 (2000).
RN [8]; RE0017525.
RX PUBMED: 8756667.
RA Oettgen P., Akbarali Y., Boltax J., Best J., Kunsch C., Libermann T. A.
RT Characterization of NERF, a novel transcription factor related to the Ets factor ELF-1
RL Mol. Cell. Biol. 16:5091-5106 (1996).
RN [9]; RE0048396.
RX PUBMED: 16818466.
RA Presnell S. R., Zhang L., Ramilo C. A., Chan H. W., Lutz C. T.
RT Functional redundancy of transcription factor-binding sites in the killer cell Ig-like receptor (KIR) gene promoter.
RL Int. Immunol. 18:1221-1232 (2006).
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