AC T01462
XX
ID T01462
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DT 25.04.1995 (created); ewi.
DT 17.06.2016 (updated); ros.
CO Copyright (C), QIAGEN.
XX
FA Fra-1
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SY FOS-like antigen 1; FOS-like antigen-1; FOSL1; Fra; Fra-1; FRA1; FraI.
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OS human, Homo sapiens
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; primates
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GE G001636 FOSL1; HGNC: FOSL1.
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CL C0008; bZIP; 1.1.2.1.3.
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SF no homodimers;
SF binds DNA as a heterodimer with Jun family members (c-Jun, JunB, JunD);
SF no interaction with TBP [3];
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CP widespread; MDA231 and MDA435s [9].
CN T cells, B cells (probably) [4]; SKBR3, MCF-7 and T47D [9].
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FF activator as a heterodimer with Jun factors [8] [2];
FF DNA binding is markedly enhanced after treatment of cells with TPA [8];
FF enhanced mRNA levels after thrombin treatment [1];
FF as a heterodimer with JunB, act synergistically with NFATp/c [2];
FF positive autoregulation of the human fra-1 gene: Fra-1 factor, as a heterodimer with JunB, binds to TRE element and activates fra-1 gene [8];
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IN T01113 Elf-1; human, Homo sapiens.
IN T04106 HDAC1; human, Homo sapiens.
IN T01977 JunB; human, Homo sapiens.
XX
MX M00517 V$AP1_01.
MX M00924 V$AP1_Q2_01.
MX M00926 V$AP1_Q4_01.
MX M00925 V$AP1_Q6_01.
MX M04897 V$FOSL1_01.
MX M07091 V$FOSL1_02.
MX M01267 V$FRA1_Q5.
MX M02095 V$FRA1_Q6.
MX M03869 V$FRA1_Q6_01.
XX
BS R23157.
BS R37572.
BS R37577.
BS R37580.
BS R37581.
BS R30618.
BS R68064.
BS R36308.
BS R41978.
BS R14540.
BS R23153.
BS R29092.
BS R30937.
BS R25018.
BS R26674.
BS R72604.
BS R72687.
BS R14724.
BS R14725.
BS R26758.
BS R36379.
BS R39281.
BS R59837.
BS R26793.
BS R24701.
BS R25054.
BS R35944.
BS R36611.
BS R08494.
BS R38461.
BS R13178.
BS R14478.
BS R14480.
BS R21765.
BS R33879.
BS R05017.
BS R05020.
XX
DR TRANSPATH: MO000025684.
DR UniProtKB: P15407;
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RN [1]; RE0002956.
RX PUBMED: 1328861.
RA Trejo J., Chambard J.-C., Karin M., Brown J. H.
RT Biphasic increase in c-jun mRNA is required for induction of AP-1-mediated gene transcription: Differential effects of muscarinic and thrombin receptor activation
RL Mol. Cell. Biol. 12:4742- 4750 (1992).
RN [2]; RE0004628.
RX PUBMED: 8441422.
RA Boise L., Petryniak B., Mao X., June C. H., Wang C.-Y., Lindsten T., Bravo R., Kovary K., Leiden J., Thompson C. B.
RT The NFAT-1 DNA binding complex in activated T cells contains Fra-1 and JunB
RL Mol. Cell. Biol. 13:1911-1919 (1993).
RN [3]; RE0004824.
RX PUBMED: 8065335.
RA Metz R., Bannister A. J., Sutherland J. A., Hagemeier C., O'Rourke E. C., Cook A., Bravo R., Kouzarides T.
RT c-Fos-induced activation of a TATA-box-containing promoter involves direct contact with TATA-box-binding protein
RL Mol. Cell. Biol. 14:6021-6029 (1994).
RN [4]; RE0004893.
RX PUBMED: 2107490.
RA Matsui M., Tokuhara M., Konuma Y., Nomura N., Ishizaki R.
RT Isolation of human fos- related genes and their expression during monocyte-macrophage differentiation
RL Oncogene 5:249-255 (1990).
RN [5]; RE0004894.
RX PUBMED: 8230424.
RA Tsuchiya H., Fujii M., Niki T., Tokuhara M., Matsui M., Seiki M.
RT Human T-cell leukemia virus type 1 Tax activates transcription of the human fra-1 gene through multiple cis elements responsive to transmembrane signals
RL J. Virol. 67:7001-7007 (1993).
RN [6]; RE0013940.
RX PUBMED: 10454570.
RA Cirillo G., Casalino L., Vallone D., Caracciolo A., De Cesare D., Verde P.
RT Role of distinct mitogen-activated protein kinase pathways and cooperation between Ets-2, ATF-2, and Jun family members in human urokinase-type plasminogen activator gene induction by interleukin-1 and tetradecanoyl phorbol acetate
RL Mol. Cell. Biol. 19:6340-6252 (1999).
RN [7]; RE0016689.
RX PUBMED: 7648395.
RA Bassuk A. G., Leiden J. M.
RT A direct physical association between ETS and AP-1 transcription factors in normal human T cells.
RL Immunity 3:223-237 (1995).
RN [8]; RE0023779.
RX PUBMED: 13679379.
RA Adiseshaiah P., Papaiahgari S. R., Vuong H., Kalvakolanu D. V., Reddy S. P.
RT Multiple cis-elements mediate the transcriptional activation of human fra-1 by 12-O-tetradecanoylphorbol-13-acetate in bronchial epithelial cells.
RL J. Biol. Chem. 278:47423-47433 (2003).
RN [9]; RE0053150.
RX PUBMED: 17572495.
RA Song Y., Qian L., Song S., Chen L., Zhang Y., Yuan G., Zhang H., Xia Q., Hu M., Yu M., Shi M., Jiang Z., Guo N.
RT Fra-1 and Stat3 synergistically regulate activation of human MMP-9 gene.
RL Mol. Immunol. 45:137-143 (2008).
RN [10]; RE0055188.
RX PUBMED: 17921324.
RA Cortez D. M., Feldman M. D., Mummidi S., Valente A. J., Steffensen B., Vincenti M., Barnes J. L., Chandrasekar B.
RT IL-17 stimulates MMP-1 expression in primary human cardiac fibroblasts via p38 MAPK- and ERK1/2-dependent C/EBP-beta, NF-kappaB, and AP-1 activation.
RL Am. J. Physiol. Heart Circ. Physiol. 293:H3356-65 (2007).
RN [11]; RE0065207.
RX PUBMED: 18249159.
RA Hamdi M., Popeijus H. E., Carlotti F., Janssen J. M., van der Burgt C., Cornelissen-Steijger P., van de Water B., Hoeben R. C., Matsuo K., van Dam H.
RT ATF3 and Fra1 have opposite functions in JNK- and ERK-dependent DNA damage responses.
RL DNA Repair (Amst.) 7:487-496 (2008).
RN [12]; RE0066649.
RX PUBMED: 16984917.
RA Byun H. J., Hong I. K., Kim E., Jin Y. J., Jeoung D. I., Hahn J. H., Kim Y. M., Park S. H., Lee H.
RT A splice variant of CD99 increases motility and MMP-9 expression of human breast cancer cells through the AKT-, ERK-, and JNK-dependent AP-1 activation signaling pathways.
RL J. Biol. Chem. 281:34833-34847 (2006).
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