AC T00593
XX
ID T00593
XX
DT 15.10.1992 (created); ewi.
DT 16.02.2015 (updated); sup.
CO Copyright (C), QIAGEN.
XX
FA NF-kappaB1-p50
XX
SY 243/NFA-kappaB; EBP-1; H2TF1; HeLa B factor; KBF1; NF-kappaB (p50); NF-kappaB1; NFKB-p50; Nuclear Factor kappa B p50; p50; TC-IIB.
XX
OS human, Homo sapiens
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; primates
XX
CL C0020; Rel; 6.1.1.1.1.
XX
SF N-terminal half of a 105 kDa precursor T01925 [18];
SF binds to DNA either as homo- or heteromer T00590 with RelA/p65 T00594 [11];
SF Cys-62 is part of a R(F/G)(R/K)YXCE motif found in also other Rel proteins as well as in zinc finger proteins that bind to kappaB sites;
SF it has to be reduced to enable DNA-binding, presumably by a nuclear thioredoxin system [33] [34] [35] [36];
SF DNA-binding domain is largely non-helical [38] [45];
SF rather, the Rel domain comprises two beta-barrel domains the loops of which constitute an extensive DNA contacting surface [38];
SF there is a major groove-binding recognition loop within the N-terminal subdomain which resembles the p53 DNA-binding domain [38];
SF the C-terminal subdomain exhibits a beta-sandwich structure resembling immunoglobulins and is contacted by IkappaB [38];
SF though not being a primary target for IkappaB, the NLS of NF-kappaB1-p50 is masked by the inhibitor in holo-NF-kappaB/IkappaB complexes [31];
SF the homodimer reveals a 10-fold higher affinity to symmetric sites than the NF-kappaB1-p50/p65 heterodimer [11];
SF the heterodimer binds more avidly to asymmetric sites: KD = 0.4 pM [11];
SF binding to some kappaB sites (e. g., IFN-beta promoter) is significantly augmented by HMG I(Y) [30];
SF DNA-binding is sensitive towards CpG methylation [39];
SF reported zinc-dependence of DNA-binding is not yet explained by structural features [12];
SF the Rel domain interacts with the leucine zipper of C/EBPbeta, and probably also of C/EBP alpha, -gamma-, and delta which also synergize with NF-kappaB [42] [46];
SF Rel-ZIP interactions have also been suggested for NF-kappaB1-p50 and ATF-a, CRE-BP1, ATF-3 [40];
SF the interaction of the Rel domain with the DNA-binding domain of ER inhibits DNA-binding by NF-kappaB1-p50 [37];
XX
CP ubiquitous; UT-7/TPO, Megakaryocytes [50]; HUVEC [61].
XX
FF induces GluR1 expression in TNF-alpha treated NT2-N neurons [48];
FF primary DNA-binding subunit of NF-kappaB;
FF homodimers may repress transcription [9] [20] [43];
FF hyperphosphorylation in the cytosol of T cells by a 43 kDa protein kinase which is associated with the NF-kappaB/IkappaB complex [32] [44];
FF phosphorylation of NF-kappaB1-p50 may contribute to NF-kappaB activation by enhancing the DNA-binding capability [44];
FF upstream signal transducers may be Raf, Src, H-Ras, Mos [41];
FF directly interacts with N-terminal region of co-activator CBP [49];
XX
IN T00167 ATF-2-isoform1; human, Homo sapiens.
IN T01313 ATF-3-isoform1; human, Homo sapiens.
IN T00052 ATFa-isoform6; human, Homo sapiens.
IN T01928 Bcl-3; human, Homo sapiens.
IN T00168 c-Rel; human, Homo sapiens.
IN T00169 c-Rel; mouse, Mus musculus.
IN T01154 c-Rel; chick, Gallus gallus.
IN T00105 C/EBPalpha; human, Homo sapiens.
IN T00581 C/EBPbeta; human, Homo sapiens.
IN T08705 Egr-4; human, Homo sapiens.
IN T01113 Elf-1; human, Homo sapiens.
IN T00261 ER-alpha; human, Homo sapiens.
IN T04106 HDAC1; human, Homo sapiens.
IN T00950 IkappaB-alpha; human, Homo sapiens.
IN T01943 IkappaBR; human, Homo sapiens.
IN T00593 NF-kappaB1-p50; human, Homo sapiens.
IN T01925 NF-kappaB1; human, Homo sapiens.
IN T01927 NF-kappaB2-p100; human, Homo sapiens.
IN T00394 NF-kappaB2-p52; human, Homo sapiens.
IN T00594 RelA-p65-isoform1; human, Homo sapiens.
IN T08711 RelA-p65; human, Homo sapiens.
IN T30703 SIRT1; Mammalia.
IN T00897 v-Rel; REV-T, reticuloendotheliosis virus (strain T).
XX
MX M00051 V$NFKAPPAB50_01.
MX M00054 V$NFKAPPAB_01.
MX M00208 V$NFKB_C.
MX M00194 V$NFKB_Q6.
MX M00774 V$NFKB_Q6_01.
MX M03557 V$P50_Q6.
XX
BS R05840.
BS R05841.
BS R05842.
BS R05843.
BS R05844.
BS R05845.
BS R05846.
BS R05847.
BS R05848.
BS R05849.
BS R05850.
BS R05851.
BS R05852.
BS R05853.
BS R05854.
BS R05855.
BS R05856.
BS R05857.
BS R30673.
BS R20924.
BS R01748.
BS R02921.
BS R26202.
BS R02144.
BS R02167.
BS R00699.
BS R00700.
BS R00702.
BS R14659.
BS R32790.
BS R39203.
BS R33617.
BS R14436.
BS R14640.
BS R39660.
BS R12279.
BS R14430.
BS R14431.
BS R25011.
BS R25442.
BS R25596.
BS R12092.
BS R20329.
BS R00920.
BS R00923.
BS R13472.
BS R13473.
BS R13474.
BS R25932.
BS R14486.
BS R00943.
BS R00933.
BS R25017.
BS R74082.
BS R29805.
BS R24123.
BS R25474.
BS R25475.
BS R25405.
BS R40999.
BS R41000.
BS R41001.
BS R17035.
BS R17045.
BS R11382.
BS R34832.
BS R16988.
BS R16989.
BS R16990.
BS R16991.
BS R16992.
BS R74063.
BS R56441.
BS R22635.
BS R24873.
BS R14565.
BS R13476.
BS R13477.
BS R02189.
BS R01095.
BS R14716.
BS R14717.
BS R00879.
BS R01744.
BS R01057.
BS R01058.
BS R01059.
BS R01065.
BS R04702.
BS R02217.
BS R13306.
BS R04905.
BS R01406.
BS R01409.
XX
DR TRANSPATH: MO000019356.
DR TRANSCOMPEL: C00234.
DR TRANSCOMPEL: C00321.
DR TRANSCOMPEL: C00325.
DR TRANSCOMPEL: C00347.
DR EMBL: M55643; HSNFKB34.
DR UniProtKB: P19838; KBF1_HUMAN.
XX
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RA Gilmore T. D.
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RT Modulation of NF-kappaB-dependent transcription and cell survival by the SIRT1 deacetylase.
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XX
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