TRANSFAC FACTOR TABLE, Release 2017.2 - public - 2017-06-30, (C) QIAGEN

AC T00593 XX ID T00593 XX DT 15.10.1992 (created); ewi. DT 16.02.2015 (updated); sup. CO Copyright (C), QIAGEN. XX FA NF-kappaB1-p50 XX SY 243/NFA-kappaB; EBP-1; H2TF1; HeLa B factor; KBF1; NF-kappaB (p50); NF-kappaB1; NFKB-p50; Nuclear Factor kappa B p50; p50; TC-IIB. XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; primates XX CL C0020; Rel; XX SF N-terminal half of a 105 kDa precursor T01925 [18]; SF binds to DNA either as homo- or heteromer T00590 with RelA/p65 T00594 [11]; SF Cys-62 is part of a R(F/G)(R/K)YXCE motif found in also other Rel proteins as well as in zinc finger proteins that bind to kappaB sites; SF it has to be reduced to enable DNA-binding, presumably by a nuclear thioredoxin system [33] [34] [35] [36]; SF DNA-binding domain is largely non-helical [38] [45]; SF rather, the Rel domain comprises two beta-barrel domains the loops of which constitute an extensive DNA contacting surface [38]; SF there is a major groove-binding recognition loop within the N-terminal subdomain which resembles the p53 DNA-binding domain [38]; SF the C-terminal subdomain exhibits a beta-sandwich structure resembling immunoglobulins and is contacted by IkappaB [38]; SF though not being a primary target for IkappaB, the NLS of NF-kappaB1-p50 is masked by the inhibitor in holo-NF-kappaB/IkappaB complexes [31]; SF the homodimer reveals a 10-fold higher affinity to symmetric sites than the NF-kappaB1-p50/p65 heterodimer [11]; SF the heterodimer binds more avidly to asymmetric sites: KD = 0.4 pM [11]; SF binding to some kappaB sites (e. g., IFN-beta promoter) is significantly augmented by HMG I(Y) [30]; SF DNA-binding is sensitive towards CpG methylation [39]; SF reported zinc-dependence of DNA-binding is not yet explained by structural features [12]; SF the Rel domain interacts with the leucine zipper of C/EBPbeta, and probably also of C/EBP alpha, -gamma-, and delta which also synergize with NF-kappaB [42] [46]; SF Rel-ZIP interactions have also been suggested for NF-kappaB1-p50 and ATF-a, CRE-BP1, ATF-3 [40]; SF the interaction of the Rel domain with the DNA-binding domain of ER inhibits DNA-binding by NF-kappaB1-p50 [37]; XX CP ubiquitous; UT-7/TPO, Megakaryocytes [50]; HUVEC [61]. XX FF induces GluR1 expression in TNF-alpha treated NT2-N neurons [48]; FF primary DNA-binding subunit of NF-kappaB; FF homodimers may repress transcription [9] [20] [43]; FF hyperphosphorylation in the cytosol of T cells by a 43 kDa protein kinase which is associated with the NF-kappaB/IkappaB complex [32] [44]; FF phosphorylation of NF-kappaB1-p50 may contribute to NF-kappaB activation by enhancing the DNA-binding capability [44]; FF upstream signal transducers may be Raf, Src, H-Ras, Mos [41]; FF directly interacts with N-terminal region of co-activator CBP [49]; XX IN T00167 ATF-2-isoform1; human, Homo sapiens. IN T01313 ATF-3-isoform1; human, Homo sapiens. IN T00052 ATFa-isoform6; human, Homo sapiens. IN T01928 Bcl-3; human, Homo sapiens. IN T00168 c-Rel; human, Homo sapiens. IN T00169 c-Rel; mouse, Mus musculus. IN T01154 c-Rel; chick, Gallus gallus. IN T00105 C/EBPalpha; human, Homo sapiens. IN T00581 C/EBPbeta; human, Homo sapiens. IN T08705 Egr-4; human, Homo sapiens. IN T01113 Elf-1; human, Homo sapiens. IN T00261 ER-alpha; human, Homo sapiens. IN T04106 HDAC1; human, Homo sapiens. IN T00950 IkappaB-alpha; human, Homo sapiens. IN T01943 IkappaBR; human, Homo sapiens. IN T00593 NF-kappaB1-p50; human, Homo sapiens. IN T01925 NF-kappaB1; human, Homo sapiens. IN T01927 NF-kappaB2-p100; human, Homo sapiens. IN T00394 NF-kappaB2-p52; human, Homo sapiens. IN T00594 RelA-p65-isoform1; human, Homo sapiens. IN T08711 RelA-p65; human, Homo sapiens. IN T30703 SIRT1; Mammalia. IN T00897 v-Rel; REV-T, reticuloendotheliosis virus (strain T). XX MX M00051 V$NFKAPPAB50_01. MX M00054 V$NFKAPPAB_01. MX M00208 V$NFKB_C. MX M00194 V$NFKB_Q6. MX M00774 V$NFKB_Q6_01. MX M03557 V$P50_Q6. XX BS R05840. BS R05841. BS R05842. BS R05843. BS R05844. BS R05845. BS R05846. BS R05847. BS R05848. BS R05849. BS R05850. BS R05851. BS R05852. BS R05853. BS R05854. BS R05855. BS R05856. BS R05857. BS R30673. BS R20924. BS R01748. BS R02921. BS R26202. BS R02144. BS R02167. BS R00699. BS R00700. BS R00702. BS R14659. BS R32790. BS R39203. BS R33617. BS R14436. BS R14640. BS R39660. BS R12279. BS R14430. BS R14431. BS R25011. BS R25442. BS R25596. BS R12092. BS R20329. BS R00920. BS R00923. BS R13472. BS R13473. BS R13474. BS R25932. BS R14486. BS R00943. BS R00933. BS R25017. BS R74082. BS R29805. BS R24123. BS R25474. BS R25475. BS R25405. BS R40999. BS R41000. BS R41001. BS R17035. BS R17045. BS R11382. BS R34832. BS R16988. BS R16989. BS R16990. BS R16991. BS R16992. BS R74063. BS R56441. BS R22635. BS R24873. BS R14565. BS R13476. BS R13477. BS R02189. BS R01095. BS R14716. BS R14717. BS R00879. BS R01744. BS R01057. BS R01058. BS R01059. BS R01065. BS R04702. BS R02217. BS R13306. BS R04905. BS R01406. BS R01409. XX DR TRANSPATH: MO000019356. DR TRANSCOMPEL: C00234. DR TRANSCOMPEL: C00321. DR TRANSCOMPEL: C00325. DR TRANSCOMPEL: C00347. DR EMBL: M55643; HSNFKB34. DR UniProtKB: P19838; KBF1_HUMAN. XX RN [1]; RE0000169. RX PUBMED: 2203533. RA Gilmore T. D. RT NF-kappaB, KBF1, dorsal, and related matters RL Cell 62:841-843 (1990). RN [2]; RE0000172. RX PUBMED: 2203531. RA Kieran M., Blank V., Logeat F., Vandekerckhove J., Lottspeich F., Le Bail O., Urban M. B., Kourilsky P., Baeuerle B. A., Israel A. RT The DNA binding subunit of NF-kappaB is identical to factor KBF1 and homologous to the rel oncogene product RL Cell 62:1007-1018 (1990). RN [3]; RE0000174. RX PUBMED: 1988149. RA Lewin B. RT Oncogenic conversion by regulatory changes in transcription factors RL Cell 64:303-312 (1991). RN [4]; RE0000285. RX PUBMED: 3076097. RA Baeuerle P. A., Lenardo M., Pierce J. W., Baltimore D. RT Phorbol-ester-induced activation of the NF-kappaB transcription factor involves dissociation of an apparently cytoplasmic NF-kappaB/inhibitor complex RL Cold Spring Harb. Symp. Quant. Biol. 53:789-798 (1988). RN [5]; RE0000357. RX PUBMED: 3138113. RA Wu F. K., Garcia J. A., Harrich D., Gaynor R. B. RT Purification of the human immunodeficiency virus type 1 enhancer and TAR binding proteins EBP-1 and UBP-1 RL EMBO J. 7:2117-2129 (1988). RN [6]; RE0000384. RX PUBMED: 3322806. RA Yano O., Kanellopoulos J., Kieran M., Le Bail O., Israel A., Kourilsky P. RT Purification of KBF1, a common factor binding to both H-2 and beta2-microglobulin enhancers RL EMBO J. 6:3317-3324 (1987). RN [7]; RE0000453. RX PUBMED: 2583102. RA Lenardo M., Rustgi A. K., Schievella A. R., Bernards R. RT Suppression of MHC class I gene expression by N-myc through enhancer inactivation RL EMBO J. 8:3351-3355 (1989). RN [8]; RE0000458. RX PUBMED: 2050119. RA Urban M. B., Schreck R., Baeuerle P. A. RT NF-kappaB contacts DNA by a heterodimer of the p50 and p65 subunit RL EMBO J. 10:1817-1825 (1991). RN [9]; RE0000506. RX PUBMED: 1935902. RA Schmitz M. L., Baeuerle P. A. RT The p65 subunit is responsible for the strong transcription activating potential of NF-kappaB RL EMBO J. 10:3805-3817 (1991). RN [10]; RE0000673. RX PUBMED: 2844627. RA Clark L., Pollock R. M., Hay R. T. RT Identification and purification of EBP1: a HeLa cell protein that binds to a region overlapping the core of the SV40 enhancer RL Genes Dev. 2:991-1002 (1988). RN [11]; RE0000726. RX PUBMED: 2125960. RA Urban M. B., Baeuerle P. A. RT The 65-kD subunit of NF-kappaB is a receptor for IkappaB and a modulator of DNA-binding specificity RL Genes Dev. 4:1975-1984 (1990). RN [12]; RE0000973. RX PUBMED: 1985897. RA Zabel U., Schreck R., Baeuerle P. A. RT DNA binding of purified transcription factor NF-kappaB RL J. Biol. Chem. 266:252-260 (1991). RN [13]; RE0001146. RX PUBMED: 2406459. RA Clark L., Matthews J. R., Hay R. T. RT Interaction of enhancer-binding protein EBP1 (NF-kappaB) with the human immunodeficiency virus type 1 enhancer RL J. Virol. 64:1335-1344 (1990). RN [14]; RE0001306. RX PUBMED: 3561391. RA Baldwin jr A. S., Sharp P. A. RT Binding of a Nuclear Factor to a Regulatory Sequence in the Promoter of the Mouse H-2Kb Class I Major Histocompatibility Gene RL Mol. Cell. Biol. 7:305-313 (1987). RN [15]; RE0001376. RX PUBMED: 2677676. RA Mauxion F., Sen R. RT Alteration of a Single Nucleotide Allows Efficient Binding of H2TF1/KBF1 to the Immunoglobulin k Enhancer B Motif RL Mol. Cell. Biol. 9:3548-3552 (1989). RN [16]; RE0001474. RX PUBMED: 2196446. RA Henseling U., Schmidt W., Schoeler H. R., Gruss P., Hatzopoulos A. K. RT A transcription factor interacting with the class I gene enhancer is inactive in tumorigenic cell lines which suppress major histocompatibility complex class I genes RL Mol. Cell. Biol. 10:4100-4109 (1990). RN [17]; RE0001632. RX PUBMED: 2548081. RA Shirakawa F., Mizel S. B. RT In vitro activation and nuclear translocation of NF-kappaB catalyzed by cyclic AMP-dependent protein kinase and protein kinase C RL Mol. Cell. Biol. 9:2424-2430 (1991). RN [18]; RE0001870. RX PUBMED: 2234062. RA Bours V., Villalobos J., Burd P. R., Kelly K., Siebenlist U. RT Cloning of a mitogen-inducible gene encoding a kappaB DNA-binding protein with homology to the rel oncogene and to cell-cycle motifs RL Nature 348:76-80 (1990). RN [19]; RE0001872. RX PUBMED: 2017258. RA Riviere Y., Blank V., Kourilsky P., Israel A. RT Processing of the precursor of NF-kappaB by the HIV-1 protease during acute infection RL Nature 350:625-626 (1991). RN [20]; RE0001873. RX PUBMED: 1876189. RA Schmid R. M., Perkins N. D., Duckett C. S., Andrews P. C., Nabel G. J. RT Cloning of an NF-kappaB subunit which stimulates HIV transcription in synergy with p65 RL Nature 352:733-736 (1991). RN [21]; RE0001874. RX PUBMED: 1956402. RA Fan C.-M., Maniatis T. RT Generation of p50 subunit of NF-kappaB by processing of p105 through an ATP-dependent pathway RL Nature 354:395-398 (1991). RN [22]; RE0001990. RX PUBMED: 2536920. RA Clark L., Hay R. T. RT Sequence requirements for specific interaction of an enhancer binding protein (EBP1) with DNA RL Nucleic Acids Res. 17:499-516 (1989). RN [23]; RE0002064. RX PUBMED: 2668878. RA Israel A., Yano O., Logeat F., Kieran M., Kourilsky P. RT Two purified factors bind to the same sequence in the enhancer of mouse MHC class I genes: one of them is a positive regulator induced upon differentiation of teratocarcinoma cells RL Nucleic Acids Res. 17:5245 (1989). RN [24]; RE0002328. RX PUBMED: 3422454. RA Baldwin jr A. S., Sharp P. A. RT Two transcription factors, NF-kB and H2TF1, interact with a single regulatory sequence in the class I major histocompatibility complex promoter RL Proc. Natl. Acad. Sci. USA 85:723-727 (1988). RN [25]; RE0002417. RX PUBMED: 2263603. RA Molitor J. A., Walker W. H., Doerre S., Ballard D. W., Greene W. C. RT NF-kappaB: a family of inducible and differentially expressed enhancer-binding proteins in human T cells RL Proc. Natl. Acad. Sci. USA 87:10028-10032 (1990). RN [26]; RE0002484. RX PUBMED: 1903539. RA Toledano M. B., Leonard W. J. RT Modulation of transcription factor NF-kappaB binding activity by oxidation-reduction in vitro RL Proc. Natl. Acad. Sci. USA 88:4328-4332 (1991). RN [27]; RE0002489. RX PUBMED: 1992489. RA Meyer R., Hatada E. N., Hohmann H.-P., Haiker M., Bartsch C., Roethlisberger U., Lahm H.-W., Schlaeger E. J., van Loon A. P. G. M., Scheidereit C. RT Cloning of the DNA-binding subunit of human nuclear factor kappaB: the level of its mRNA is strongly regulated by phorbol ester or tumor necrosis factor alpha RL Proc. Natl. Acad. Sci. USA 88:966-970 (1991). RN [28]; RE0002491. RX PUBMED: 2247438. RA Rustgi A. K., van't Veer L., Bernards R. RT Two genes encode factors with NF-kappaB- and H2TF1-like DNA-binding properties RL Proc. Natl. Acad. Sci. USA 87:8707-8710 (1990). RN [29]; RE0002873. RX PUBMED: 1756723. RA Blank V., Kourilsky P., Israel A. RT Cytoplasmic retention, DNA binding and processing of the NF--kappaB p50 precursor are controlled by a small region in its C-terminus RL EMBO J. 10:4159-4167 (1991). RN [30]; RE0004376. RX PUBMED: 1330326. RA Thanos D., Maniatis T. RT The high mobility group protein HMG I(Y) is required for NF-kappaB-dependent virus induction of the human IFN-beta gene RL Cell 71:777-789 (1992). RN [31]; RE0004487. RX PUBMED: 7679069. RA Zabel U., Henkel T., dos Santos Silva M., Baeuerle P. A. RT Nuclear uptake control of NF-kappaB by MAD-3, an IkappB protein present in the nucleus RL EMBO J. 12:201-211 (1993). RN [32]; RE0004496. RX PUBMED: 8253816. RA Hayashi T., Sekine T., Okamoto T. RT Identification of a new serine kinase that activates NFkappaB by direct phosphorylation RL J. Biol. Chem. 268:26790-26795 (1993). RN [33]; RE0004497. RX PUBMED: 1508666. RA Matthews J. R., Wakasugi N., Virelizier J. L., Yodoi J., Hay R. T. RT Thioredoxin regulates the DNA binding activity of NF-kappaB by reduction of a disulphide bond involving cysteine 62 RL Nucleic Acids Res. 20:3821-3830 (1992). RN [34]; RE0004498. RX PUBMED: 8493089. RA Matthews J. R., Kaszubska W., Turcatti G., Wells T. N. C., Hay R. T. RT Role of cysteine62 in DNA recognition by the P50 subunit of NF-kappaB RL Nucleic Acids Res. 21:1727-1734 (1993). RN [35]; RE0004499. RX PUBMED: 8496188. RA Hayashi T., Ueno Y., Okamoto T. RT Oxidoreductive regulation of Nuclear Factor kappa B (Involvement of a cellular reducing catalyst thioredoxin) RL J. Biol. Chem. 268:11380-11388 (1993). RN [36]; RE0004501. RX PUBMED: 8423807. RA Toledano M. B., Ghosh D., Trinh F., Leonard W. J. RT N-terminal DNA-Binding contribute to differential DNA-binding specifities of NF-kappaB p50 and p65 RL Mol. Cell. Biol. 13:852-860 (1993). RN [37]; RE0004503. RX PUBMED: 7651415. RA Stein B., Yang M. X. RT Repression of the interleukin-6 promoter by estrogen receptor is mediated by NF-kappaB and C/EBPbeta RL Mol. Cell. Biol. 15:4971-4979 (1995). RN [38]; RE0004505. RX PUBMED: 7830764. RA Mueller C. W., Rey F. A., Sodeoka M., Verdine G. L., Harrison S. C. RT Structure of the NF-kappaB p50 homodimer bound to DNA RL Nature 373:311-317 (1995). RN [39]; RE0004513. RX PUBMED: 1768651. RA Bednarik D. P., Duckett C., Kim S. U., Perez V. L., Griffis K., Guenther P. C., Folks T. M. RT DNA CpG methylation inhibits binding of NF-kappaB proteins to the HIV-1 long terminal repeat cognate DNA motifs RL New Biol. 3:969-976 (1991). RN [40]; RE0004521. RX PUBMED: 7692236. RA Kaszubska W., Hooft van Huijsduijnen R., Ghersa P., DeRaemy-Schenk A.-M., Chen B. P. C., Hai T., DeLamarter J. F., Whelan J. RT Cyclic AMP-independent ATF family members interact with NF-kappaB and function in the activation of the E-selectin promoter in response to cytokines RL Mol. Cell. Biol. 13:7180-7190 (1993). RN [41]; RE0004523. RX PUBMED: 8367725. RA Devary Y., Rosette C., Didonato J. A., Karin M. RT NF-kappaB activation by ultraviolet light not dependent on a nuclear signal RL Science 261:1442-1445 (1993). RN [42]; RE0004524. RX PUBMED: 8321203. RA Stein B., Cogswell P. C., Baldwin jr A. S. RT Functional and physical associations between NF-kappaB and C/EBP family members: a Rel domain-bZIP interaction RL Mol. Cell. Biol. 13:3964-3974 (1993). RN [43]; RE0004525. RX PUBMED: 8496683. RA Plaksin D., Baeuerle P. A., Eisenbach L. RT KBF1 (p50 NF-kappaB homodimer) acts as a repressor of H-2Kb gene expression in metastatic tumor cells RL J. Exp. Med. 177:1651-1662 (1993). RN [44]; RE0004527. RX PUBMED: 7982908. RA Li C.-C., Dai R.-M., Chen E., Longo D. L. RT Phosphorylation of NF-KB1-p50 is involved in NF-kappaB activation and stable DNA binding RL J. Biol. Chem. 269:30089-30092 (1994). RN [45]; RE0004529. RX PUBMED: 8302865. RA Liu J., Sodeoka M., Lane W. S., Verdine G. L. RT Evidence for a non-alpha-helical DNA-binding motif in the Rel homology region RL Proc. Natl. Acad. Sci. USA 91:908-912 (1994). RN [46]; RE0016587. RX PUBMED: 1518839. RA LeClair K. P., Blanar M. A., Sharp P. A. RT The p50 subunit of NF-kB associates with the NF-IL6 transcription factor. RL Proc. Natl. Acad. Sci. USA 89:8145-8149 (1992). RN [47]; RE0016682. RX PUBMED: 9094628. RA Bassuk A. G., Anandappa R. T., Leiden J. M. RT Physical interactions between Ets and NF-kappaB/NFAT proteins play an important role in their cooperative activation of the human immunodeficiency virus enhancer in T cells. RL J. Virol. 71:3563-3573 (1997). RN [48]; RE0023372. RX PUBMED: 12460558. RA Yu Z., Cheng G., Wen X., Wu G. D., Lee W. T., Pleasure D. RT Tumor necrosis factor alpha increases neuronal vulnerability to excitotoxic necrosis by inducing expression of the AMPA-glutamate receptor subunit GluR1 via an acid sphingomyelinase- and NF-kappaB-dependent mechanism. RL Neurobiol. Dis. 11:199-213 (2002). RN [49]; RE0024015. RX PUBMED: 12403783. RA Hiroi M., Ohmori Y. RT The transcriptional coactivator CREB-binding protein cooperates with STAT1 and NF-kappa B for synergistic transcriptional activation of the CXC ligand 9/monokine induced by interferon-gamma gene. RL J. Biol. Chem. 278:651-660 (2003). RN [50]; RE0029138. RX PUBMED: 11756417. RA Kirito K., Watanabe T., Sawada K., Endo H., Ozawa K., Komatsu N. RT Thrombopoietin regulates Bcl-xL gene expression through Stat5 and phosphatidylinositol 3-kinase activation pathways. RL J. Biol. Chem. 277:8329-37 (2002). RN [51]; RE0031419. RX PUBMED: 12972430. RA Viatour P., Legrand-Poels S., van Lint C., Warnier M., Merville M. P., Gielen J., Piette J., Bours V., Chariot A. RT Cytoplasmic IkappaBalpha increases NF-kappaB-independent transcription through binding to histone deacetylase (HDAC) 1 and HDAC3. RL J. Biol. Chem. 278:46541-8 (2003). RN [52]; RE0046041. RX PUBMED: 12040027. RA Islam K. N., Mendelson C. R. RT Potential role of nuclear factor kappaB and reactive oxygen species in cAMP and cytokine regulation of surfactant protein-A gene expression in lung type II cells RL Mol. Endocrinol. 16:1428-40 (2002). RN [53]; RE0047425. RX PUBMED: 16014385. RA Wieland G. D., Nehmann N., Muller D., Eibel H., Siebenlist U., Suhnel J., Zipfel P. F., Skerka C. RT Early growth response proteins EGR-4 and EGR-3 interact with immune inflammatory mediators NF-kappaB p50 and p65. RL J. Cell Sci. 118:3203-3212 (2005). RN [54]; RE0047426. RX PUBMED: 15677444. RA Fagerlund R., Kinnunen L., Kohler M., Julkunen I., Melen K. RT NF-{kappa}B is transported into the nucleus by importin {alpha}3 and importin {alpha}4. RL J. Biol. Chem. 280:15942-15951 (2005). RN [55]; RE0047741. RX PUBMED: 9624136. RA Boland M. P., O'Neill L. A. RT Ceramide activates NFkappaB by inducing the processing of p105. RL J. Biol. Chem. 273:15494-15500 (1998). RN [56]; RE0048551. RX PUBMED: 16254192. RA Paz-Priel I., Cai D. H., Wang D., Kowalski J., Blackford A., Liu H., Heckman C. A., Gombart A. F., Koeffler H. P., Boxer L. M., Friedman A. D. RT CCAAT/enhancer binding protein alpha (C/EBPalpha) and C/EBPalpha myeloid oncoproteins induce bcl-2 via interaction of their basic regions with nuclear factor-kappaB p50. RL Mol. Cancer Res. 3:585-596 (2005). RN [57]; RE0051864. RX PUBMED: 17000776. RA Liu Y., Smith P. W., Jones D. R. RT Breast cancer metastasis suppressor 1 functions as a corepressor by enhancing histone deacetylase 1-mediated deacetylation of RelA/p65 and promoting apoptosis. RL Mol. Cell. Biol. 26:8683-8696 (2006). RN [58]; RE0051974. RX PUBMED: 15494311. RA Hoberg J. E., Yeung F., Mayo M. W. RT SMRT derepression by the IkappaB kinase alpha: a prerequisite to NF-kappaB transcription and survival. RL Mol. Cell 16:245-255 (2004). RN [59]; RE0052155. RX PUBMED: 15152190. RA Yeung F., Hoberg J. E., Ramsey C. S., Keller M. D., Jones D. R., Frye R. A., Mayo M. W. RT Modulation of NF-kappaB-dependent transcription and cell survival by the SIRT1 deacetylase. RL EMBO J. 23:2369-2380 (2004). RN [60]; RE0053386. RX PUBMED: 18383035. RA Gregory D. J., Godbout M., Contreras I., Forget G., Olivier M. RT A novel form of NF-kappaB is induced by Leishmania infection: involvement in macrophage gene expression. RL Eur. J. Immunol. 38:1071-1081 (2008). RN [61]; RE0053454. RX PUBMED: 17675290. RA Wang J., Mahmud S. A., Bitterman P. B., Huo Y., Slungaard A. RT Histone deacetylase inhibitors suppress TF-kappaB-dependent agonist-driven tissue factor expression in endothelial cells and monocytes. RL J. Biol. Chem. 282:28408-28418 (2007). RN [62]; RE0053839. RX PUBMED: 16407239. RA Mattioli I., Geng H., Sebald A., Hodel M., Bucher C., Kracht M., Schmitz M. L. RT Inducible phosphorylation of NF-kappa B p65 at serine 468 by T cell costimulation is mediated by IKK epsilon. RL J. Biol. Chem. 281:6175-6183 (2006). RN [63]; RE0053845. RX PUBMED: 12709443. RA Derudder E., Dejardin E., Pritchard L. L., Green D. R., Korner M., Baud V. RT RelB/p50 dimers are differentially regulated by tumor necrosis factor-alpha and lymphotoxin-beta receptor activation: critical roles for p100. RL J. Biol. Chem. 278:23278-23284 (2003). RN [64]; RE0053976. RX PUBMED: 15708970. RA Hauer J., Puschner S., Ramakrishnan P., Simon U., Bongers M., Federle C., Engelmann H. RT TNF receptor (TNFR)-associated factor (TRAF) 3 serves as an inhibitor of TRAF2/5-mediated activation of the noncanonical NF-kappaB pathway by TRAF-binding TNFRs. RL Proc. Natl. Acad. Sci. USA 102:2874-2879 (2005). RN [65]; RE0058894. RX PUBMED: 11753650. RA Bren G. D., Solan N. J., Miyoshi H., Pennington K. N., Pobst L. J., Paya C. V. RT Transcription of the RelB gene is regulated by NF-kappaB. RL Oncogene 20:7722-7733 (2001). RN [66]; RE0064761. RX PUBMED: 17827154. RA Sun J. M., Chen H. Y., Davie J. R. RT Differential distribution of unmodified and phosphorylated histone deacetylase 2 in chromatin. RL J. Biol. Chem. 282:33227-33236 (2007). XX //